Výsledky vyhledávání - "Orval A. Bateman"

Urochordate betagamma-crystallin and the evolutionary origin of the vertebrate eye lens

Autor: Christine Slingsby, Orval A. Bateman, Sebastian M. Shimeld, Andrew G. Purkiss, Ron P. Dirks, Nicolette H. Lubsen

Publikováno v: Current Biology, 15, 1684-1689
Current Biology, 15, 18, pp. 1684-1689

A refracting lens is a key component of our image-forming camera eye; however, its evolutionary origin is unknown because precursor structures appear absent in nonvertebrates. The vertebrate betagamma-crystallin genes encode abundant structural prote

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::77d5a0dbda0bbc6526ce97c46007b165
https://doi.org/10.1016/j.cub.2005.08.046

Zobrazit plný text záznamu

A reference dataset for circular dichroism spectroscopy tailored for the βγ-crystallin lens proteins

Autor: Christine Slingsby, Orval A. Bateman, Bonnie A. Wallace, Paul C. Evans

Publikováno v: Experimental Eye Research. 84:1001-1008

Circular dichroism (CD) spectroscopy is a powerful solution technique for the study of protein secondary structure. As hierarchical euclidean clustering analyses of high quality crystallin synchrotron radiation circular dichroism (SRCD) spectral data

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8eb72ebda624aa995423317a9d37474b
https://doi.org/10.1016/j.exer.2007.01.016

Zobrazit plný text záznamu

Lengsin Is a Survivor of an Ancient Family of Class I Glutamine Synthetases Re-engineered by Evolution for a Role in the Vertebrate Lens

Autor: Graeme Wistow, Keith Wyatt, Christine Slingsby, Elena V. Orlova, Luchun Wang, Orval A. Bateman, Helen E. White

Publikováno v: Structure. 14(12):1823-1834

Summary Lengsin is a major protein of the vertebrate eye lens. It belongs to the hitherto purely prokaryotic GS I branch of the glutamine synthetase (GS) superfamily, but has no enzyme activity. Like the taxon-specific crystallins, Lengsin is the res

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d886c5b95edcdb7e0c6743277efa407d

Zobrazit plný text záznamu

γN-crystallin and the evolution of the βγ-crystallin superfamily in vertebrates

Autor: Steven L. Bernstein, Orval A. Bateman, Graeme Wistow, Chun Gao, Keith Wyatt, Stanislav I. Tomarev, Thomas S. Vihtelic, Larry L. David, Christine Slingsby, Lorenzo Segovia

Publikováno v: FEBS Journal. 272:2276-2291

The β and γ crystallins are evolutionarily related families of proteins that make up a large part of the refractive structure of the vertebrate eye lens. Each family has a distinctive gene structure that reflects a history of successive gene duplic

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::5faa338ec3735208a3c823591d09752d
https://doi.org/10.1111/j.1742-4658.2005.04655.x

Zobrazit plný text záznamu

The P23T Cataract Mutation Causes Loss of Solubility of Folded γD-Crystallin

Autor: Keith Wyatt, Paul C. Evans, Graeme Wistow, Orval A. Bateman, Bonnie A. Wallace, Christine Slingsby

Publikováno v: Journal of Molecular Biology. 343:435-444

Mutations in the human gammaD-crystallin gene have been linked to several types of congenital cataracts. In particular, the Pro23 to Thr (P23T) mutation of human gammaD crystallin has been linked to cerulean, lamellar, coralliform, and fasciculiform

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3bc34f1ca7afe7c5463af9870dfa0cce
https://doi.org/10.1016/j.jmb.2004.08.050

Zobrazit plný text záznamu

The stability of human acidic β-crystallin oligomers and hetero-oligomers

Autor: R. Sarra, Guido Kappé, Orval A. Bateman, Christine Slingsby, S.T. van Genesen, Nicolette H. Lubsen

Publikováno v: Experimental Eye Research. 77:409-422

Crystallins are bulk structural proteins of the eye lens that have to last a life time. They gradually become modified with age, denature and form light scattering centres. High thermodynamic and kinetic stability of the crystallins enables them to r

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ed6d96eae649977abfa4fb86fd6e0e8d
https://doi.org/10.1016/s0014-4835(03)00173-8

Zobrazit plný text záznamu

Crystal Structure of η-Crystallin: Adaptation of a Class 1 Aldehyde Dehydrogenase for a New Role in the Eye Lens

Autor: R. Van Montfort, Andrew G Purkiss, Orval A Bateman, C Graham, C Slingsby, Graeme Wistow

Publikováno v: Biochemistry. 42:4349-4356

Eta-crystallin is a retinal dehydrogenase that has acquired a role as a structural protein in the eye lens of elephant shrews, members of an ancient order of mammals. While it retains some activity toward retinal, which is oxidized to retinoic acid,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::742fd3172eadbc8d97cca1ba481cfdf0
https://doi.org/10.1021/bi027367w

Zobrazit plný text záznamu

The X-ray Crystal Structure of Human γS-crystallin C-terminal Domain

Autor: Nicolette H. Lubsen, Julia M. Goodfellow, Christine Slingsby, Orval A. Bateman, Andrew G. Purkiss

Publikováno v: Journal of Biological Chemistry. 277:4199-4205

gammaS-crystallin is a major human lens protein found in the outer region of the eye lens, where the refractive index is low. Because crystallins are not renewed they acquire post-translational modifications that may perturb stability and solubility.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9528d40418fc8b171c296844a87872e0
https://doi.org/10.1074/jbc.m110083200

Zobrazit plný text záznamu

X-ray diffraction and structure of crystallins

Autor: David S. Moss, A. Simpson, G. Wright, Orval A. Bateman, H.P.C. Driessen, P.F. Lindley, Benjamin D. Bax, B.V. Norledge, Christine Slingsby

Publikováno v: Progress in Retinal and Eye Research. 16:3-29

The 3-dimensional organisation of crystallin polypeptides into globular proteins and their interactions into higher order structures are important factors governing optical functions related to refraction, accommodation and transparency. Single cryst

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ce1260d594ef029b2c12d16b378998af
https://doi.org/10.1016/s1350-9462(96)00018-3

Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání