Conjugates of Ciprofloxacin and Amphiphilic Block Copoly(2-alkyl-2-oxazolines)s Overcome Efflux Pumps and Are Active against CIP-Resistant Bacteria.

Autor: Romanovska A; Biomaterials and Polymer Science, Department of Bio- and Chemical Engineering, TU Dortmund, Emil-Figge-Str. 66, 44227 Dortmund, Germany., Keil J; Biomaterials and Polymer Science, Department of Bio- and Chemical Engineering, TU Dortmund, Emil-Figge-Str. 66, 44227 Dortmund, Germany., Tophoven J; Biomaterials and Polymer Science, Department of Bio- and Chemical Engineering, TU Dortmund, Emil-Figge-Str. 66, 44227 Dortmund, Germany., Oruc MF; Biomaterials and Polymer Science, Department of Bio- and Chemical Engineering, TU Dortmund, Emil-Figge-Str. 66, 44227 Dortmund, Germany., Schmidt M; Biomaterials and Polymer Science, Department of Bio- and Chemical Engineering, TU Dortmund, Emil-Figge-Str. 66, 44227 Dortmund, Germany., Breisch M; BG University Hospital Bergmannsheil Bochum/Surgical Research, Ruhr University Bochum, Buerkle-de-la-Camp-Platz 1, D-44789 Bochum, Germany., Sengstock C; BG University Hospital Bergmannsheil Bochum/Surgical Research, Ruhr University Bochum, Buerkle-de-la-Camp-Platz 1, D-44789 Bochum, Germany., Weidlich D; Institute for Physical Chemistry, University of Muenster, Corrensstrasse 30, 48149 Muenster, Germany., Klostermeier D; Institute for Physical Chemistry, University of Muenster, Corrensstrasse 30, 48149 Muenster, Germany., Tiller JC; Biomaterials and Polymer Science, Department of Bio- and Chemical Engineering, TU Dortmund, Emil-Figge-Str. 66, 44227 Dortmund, Germany.

Publikováno v: Molecular pharmaceutics [Mol Pharm] 2021 Sep 06; Vol. 18 (9), pp. 3532-3543. Date of Electronic Publication: 2021 Jul 29.