Supplementary Data from Dual Epitope Targeting and Enhanced Hexamerization by DR5 Antibodies as a Novel Approach to Induce Potent Antitumor Activity Through DR5 Agonism

Autor: Esther C.W. Breij, Rob N. de Jong, Paul W.H.I. Parren, Janine Schuurman, Ulf Forssmann, Andreas Lingnau, Richard G. Hibbert, Naomi Hoevenaars, Bart de Jong, Thessa Kroes, Boris S. Vuillermoz, Claudine Vermot-Desroches, Antonio Ortiz Buijsse, Frank J. Beurskens, Kristin Strumane, Marije B. Overdijk

Supplemental Tables Supplemental Figures Supplemental Methods

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0fc0742629adc9c9f5ee0bce476596b4
https://doi.org/10.1158/1535-7163.22520991.v1

Preclinical assessment of anti-CD40 Mab 5D12 in cynomolgus monkeys

Autor: Boon, Louis ^*, Laman, Jon D., Ortiz-Buijsse, Antonio, den Hartog, Marcel T., Hoffenberg, Simon, Liu, Patrick, Shiau, Fred, de Boer, Mark

Publikováno v: In Toxicology 2002 174(1):53-65

Crosstalk between Human IgG Isotypes and Murine Effector Cells

Autor: Paul W. H. I. Parren, Antonio Ortiz Buijsse, Wim K. Bleeker, Sandra Verploegen, Jeanette H. W. Leusen, Tom Vink, Marije B. Overdijk

Publikováno v: The Journal of Immunology. 189:3430-3438

Development of human therapeutic Abs has led to reduced immunogenicity and optimal interactions with the human immune system in patients. Humanization had as a consequence that efficacy studies performed in mouse models, which represent a crucial ste

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b5d0fb798fdb16e9bcc1d46a86d9b632
https://doi.org/10.4049/jimmunol.1200356

Cloning and expression of cDNA coding for bouganin

Autor: Chiara Lubelli, Fiorenzo Stirpe, Sijmie Heerkens, Louis Boon, Mark de Boer, Marcel T. den Hartog, Antonio P. Ortiz Buijsse

Publikováno v: European Journal of Biochemistry. 269:1772-1779

Bouganin is a ribosome-inactivating protein that recently was isolated from Bougainvillea spectabilis Willd. In this work, the cloning and expression of the cDNA encoding for bouganin is described. From the cDNA, the amino-acid sequence was deduced,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ab589cfca1f133e7ad07f640ce029a8f
https://doi.org/10.1046/j.1432-1327.2002.02823.x

Therapeutic IgG4 antibodies engage in Fab-arm exchange with endogenous human IgG4 in vivo

Autor: Ewald T. J. van den Bremer, Jan G. J. van de Winkel, Aran F. Labrijn, Antonio Ortiz Buijsse, Paul W. H. I. Parren, Rob C. Aalberse, Wim K. Bleeker, Janine Schuurman, Annemiek Y W Verwilligen, Susan J. Thorpe, Chris H. Polman, Joep Killestein

Publikováno v: Nature biotechnology, 27(8), 767-771. Nature Publishing Group
Nature Biotechnology, 27(8), 767-U122. Nature Publishing Group
Labrijn, A F, Buijsse, A O, van den Bremer, E T J, Verwilligen, A Y W, Bleeker, W K, Thorpe, S J, Killestein, J, Polman, C H, Aalberse, R C, Schuurman, J, Winkel, J G J & Parren, P W H I 2009, ' Therapeutic IgG4 antibodies engage in Fab-arm exchange with endogenous human IgG4 in vivo ', Nature Biotechnology, vol. 27, no. 8, pp. 767-771 . https://doi.org/10.1038/nbt.1553
Nature Biotechnology, 27(8), 767. Nature Publishing Group
Nature Biotechnology, 27(8), 767-771. Nature Publishing Group

Two humanized IgG4 antibodies, natalizumab and gemtuzumab, are approved for human use, and several others, like TGN1412, are or have been in clinical development. Although IgG4 antibodies can dynamically exchange half-molecules(1), Fab-arm exchange w

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dfa1647d790aa1bbb357b695ad5c6d7f
https://dspace.library.uu.nl/handle/1874/43881