Bronchoconstriction damages airway epithelia by crowding-induced excess cell extrusion.

Autor: Bagley DC; The Randall Centre for Cell & Molecular Biophysics, School of Basic & Medical Biosciences, King's College London, London SE1 1UL, UK., Russell T; The Randall Centre for Cell & Molecular Biophysics, School of Basic & Medical Biosciences, King's College London, London SE1 1UL, UK., Ortiz-Zapater E; Department of Biochemistry and Molecular Biology, University of Valencia, 46010 Valencia, Spain., Stinson S; Institute for Lung Health, Leicester NIHR BRC, University of Leicester, Leicester LE3 9QP, UK., Fox K; Edwards Life Sciences, Draper, UT 84020, USA., Redd PF; University of Utah, Salt Lake City, UT 84112, USA., Joseph M; University of Utah School of Medicine, Salt Lake City, UT 84132, USA., Deering-Rice C; College of Pharmacy, University of Utah, Salt Lake City, UT 84112, USA., Reilly C; College of Pharmacy, University of Utah, Salt Lake City, UT 84112, USA., Parsons M; The Randall Centre for Cell & Molecular Biophysics, School of Basic & Medical Biosciences, King's College London, London SE1 1UL, UK., Brightling C; Institute for Lung Health, Leicester NIHR BRC, University of Leicester, Leicester LE3 9QP, UK., Rosenblatt J; The Randall Centre for Cell & Molecular Biophysics, School of Basic & Medical Biosciences, King's College London, London SE1 1UL, UK.; School of Cancer and Pharmaceutical Sciences, King's College London, London SE1 1UL, UK.

Publikováno v: Science (New York, N.Y.) [Science] 2024 Apr 05; Vol. 384 (6691), pp. 66-73. Date of Electronic Publication: 2024 Apr 04.

Sphingosine-1-phosphate induces airway smooth muscle hyperresponsiveness and proliferation.

Autor: Maguire TJA; School of Immunology and Microbial Sciences, King's College London, London, United Kingdom; Asthma UK Centre in Allergic Mechanisms of Asthma, London, United Kingdom., Yung S; Department of Adult Allergy, Guy's and St Thomas' NHS Foundation Trust, London, United Kingdom., Ortiz-Zapater E; Randall Centre for Cell & Molecular Biophysics, King's College London, London, United Kingdom; Department of Biochemistry and Molecular Biology, Faculty of Medicina-IIS INCLIVA, University of Valencia, Valencia, Spain., Kayode OS; Department of Adult Allergy, Guy's and St Thomas' NHS Foundation Trust, London, United Kingdom., Till S; School of Immunology and Microbial Sciences, King's College London, London, United Kingdom; Asthma UK Centre in Allergic Mechanisms of Asthma, London, United Kingdom., Corrigan C; School of Immunology and Microbial Sciences, King's College London, London, United Kingdom; Asthma UK Centre in Allergic Mechanisms of Asthma, London, United Kingdom., Siew LQC; Department of Adult Allergy, Guy's and St Thomas' NHS Foundation Trust, London, United Kingdom., Knock GA; School of Immunology and Microbial Sciences, King's College London, London, United Kingdom., Woszczek G; School of Immunology and Microbial Sciences, King's College London, London, United Kingdom; Asthma UK Centre in Allergic Mechanisms of Asthma, London, United Kingdom. Electronic address: grzegorz.woszczek@kcl.ac.uk.

Publikováno v: The Journal of allergy and clinical immunology [J Allergy Clin Immunol] 2023 Nov; Vol. 152 (5), pp. 1131-1140.e6. Date of Electronic Publication: 2023 Jul 19.

Epithelial coxsackievirus adenovirus receptor promotes house dust mite-induced lung inflammation.

Autor: Ortiz-Zapater E; Randall Centre for Cell & Molecular Biophysics, King's College London, London, UK.; Peter Gorer Department of Immunobiology, School of Immunology and Microbial Science King's College London, London, UK., Bagley DC; Randall Centre for Cell & Molecular Biophysics, King's College London, London, UK., Hernandez VL; Randall Centre for Cell & Molecular Biophysics, King's College London, London, UK., Roberts LB; School of Immunology and Microbial Sciences, King's College London, London, UK., Maguire TJA; Department of Infectious Diseases, School of Immunology & Microbial Sciences, King's College London, London, UK., Voss F; Max-Delbrück-Centrum für Molekulare Medizin in the Helmholtz Assoziation (MDC), Berlin, Germany.; DZHK Partner site Berlin, Berlin, Germany., Mertins P; Berlin Institute of Health at Charité, Universitaetsmedizin Berlin, Max Delbrück Center for Molecular Medicine (MDC), Berlin, Germany., Kirchner M; Berlin Institute of Health at Charité, Universitaetsmedizin Berlin, Max Delbrück Center for Molecular Medicine (MDC), Berlin, Germany., Peset-Martin I; Medicines Discovery Catapult, Alderley Park, Macclesfield, Cheshire, UK., Woszczek G; School of Immunology and Microbial Sciences, King's College London, London, UK., Rosenblatt J; Randall Centre for Cell & Molecular Biophysics, King's College London, London, UK., Gotthardt M; Max-Delbrück-Centrum für Molekulare Medizin in the Helmholtz Assoziation (MDC), Berlin, Germany.; Berlin Institute of Health at Charité, Universitaetsmedizin Berlin, Max Delbrück Center for Molecular Medicine (MDC), Berlin, Germany.; Charité Universitätsmedizin Berlin, Berlin, Germany., Santis G; Peter Gorer Department of Immunobiology, School of Immunology and Microbial Science King's College London, London, UK.; Department of Respiratory Medicine, Guy's & St Thomas NHS Trust, London, UK., Parsons M; Randall Centre for Cell & Molecular Biophysics, King's College London, London, UK. maddy.parsons@kcl.ac.uk.

Publikováno v: Nature communications [Nat Commun] 2022 Oct 27; Vol. 13 (1), pp. 6407. Date of Electronic Publication: 2022 Oct 27.

The Role of Aryl Hydrocarbon Receptor in the Endothelium: A Systematic Review.

Autor: Guerra-Ojeda S; Department of Physiology, University of Valencia, 46010 Valencia, Spain.; Biomedical Research Institute INCLIVA, University of Valencia, 46010 Valencia, Spain., Suarez A; Department of Physiology, University of Valencia, 46010 Valencia, Spain.; Biomedical Research Institute INCLIVA, University of Valencia, 46010 Valencia, Spain., Valls A; Department of Physiology, University of Valencia, 46010 Valencia, Spain., Verdú D; Department of Physiology, University of Valencia, 46010 Valencia, Spain., Pereda J; Department of Physiology, University of Valencia, 46010 Valencia, Spain., Ortiz-Zapater E; Biomedical Research Institute INCLIVA, University of Valencia, 46010 Valencia, Spain.; Department of Biochemistry and Molecular Biology, University of Valencia, 46010 Valencia, Spain., Carretero J; Department of Physiology, University of Valencia, 46010 Valencia, Spain., Mauricio MD; Department of Physiology, University of Valencia, 46010 Valencia, Spain.; Biomedical Research Institute INCLIVA, University of Valencia, 46010 Valencia, Spain., Serna E; Department of Physiology, University of Valencia, 46010 Valencia, Spain.; Biomedical Research Institute INCLIVA, University of Valencia, 46010 Valencia, Spain.

Publikováno v: International journal of molecular sciences [Int J Mol Sci] 2023 Aug 31; Vol. 24 (17). Date of Electronic Publication: 2023 Aug 31.

Lung Fibrosis and Fibrosis in the Lungs: Is It All about Myofibroblasts?

Autor: Ortiz-Zapater E; Department of Biochemistry and Molecular Biology, Faculty of Medicine-IIS INCLIVA, University of Valencia, 46010 Valencia, Spain., Signes-Costa J; Pulmonary Department, Hospital Clinico, INCLIVA, 46010 Valencia, Spain., Montero P; Department of Pharmacology, Faculty of Medicine, University of Valencia, 46010 Valencia, Spain., Roger I; Department of Pharmacology, Faculty of Medicine, University of Valencia, 46010 Valencia, Spain.; Biomedical Research Networking Centre on Respiratory Diseases (CIBERES), Health Institute Carlos III, 28029 Madrid, Spain.

Publikováno v: Biomedicines [Biomedicines] 2022 Jun 15; Vol. 10 (6). Date of Electronic Publication: 2022 Jun 15.