Zobrazeno 1 - 10
of 141
pro vyhledávání: '"Orthotopic xenograft model"'
Autor:
Wei Chen, Wei-Min Chen, Si-Xia Chen, Li Jiang, Ge-Ge Shu, Yuan-Xiu Yin, Zhi-Peng Quan, Zi-Yan Zhou, Ming-Jun Shen, Ya-Ting Qin, Chao-Lin Yang, Xue-Jin Su, Min Kang
Publikováno v:
Cancer Biology & Therapy, Vol 25, Iss 1 (2024)
Mouse orthotopic xenograft tumor models are commonly employed in studies investigating the mechanisms underlying the development and progression of tumors and their preclinical treatment. However, the unavailability of mature and visualized orthotopi
Externí odkaz:
https://doaj.org/article/d8ab25ddda6b4c52a2e97b0646860eff
Autor:
Monika Raab, Izabela Kostova, Samuel Peña‐Llopis, Daniela Fietz, Monika Kressin, Seyed Mohsen Aberoumandi, Evelyn Ullrich, Sven Becker, Mourad Sanhaji, Klaus Strebhardt
Publikováno v:
Cancer Communications, Vol 44, Iss 1, Pp 101-126 (2024)
Abstract Background The cellular tumor protein p53 (TP53) is a tumor suppressor gene that is frequently mutated in human cancers. Among various cancer types, the very aggressive high‐grade serous ovarian carcinoma (HGSOC) exhibits the highest preva
Externí odkaz:
https://doaj.org/article/cdcbdaaef4af4c5cad1851cbfb3a4e85
Autor:
Yang Zhang, Yunxiang Shao, Yanyan Li, Xuetao Li, Xuewen Zhang, Qinzhi E, Weichao Wang, Zuoyu Jiang, Wenjuan Gan, Yulun Huang
Publikováno v:
Cancer Medicine, Vol 13, Iss 4, Pp n/a-n/a (2024)
Abstract Background The intra‐ and inter‐tumoral heterogeneity of gliomas and the complex tumor microenvironment make accurate treatment of gliomas challenging. At present, research on gliomas mainly relies on cell lines, stem cell tumor spheres,
Externí odkaz:
https://doaj.org/article/035a143f38904af99de52682422eb4db
Autor:
Yuta Takeuchi, Yizheng Wang, Katsunori Sasaki, Osamu Sato, Takahiro Tsuchikawa, Linan Wang, Yasunori Amaishi, Sachiko Okamoto, Junichi Mineno, Yoshifumi Hirokawa, Kanako C. Hatanaka, Yutaka Hatanaka, Takuma Kato, Hiroshi Shiku, Satoshi Hirano
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 170, Iss , Pp 116052- (2024)
Chimeric antigen receptor T-cell (CAR-T) therapy has demonstrated impressive success in the treatment of patients with hematologic tumors yet achieved very limited efficacy for solid tumors due to hurdles unique to solid tumors. It is also noted that
Externí odkaz:
https://doaj.org/article/88465710c13d4cf39acdbf42b435c5e8
Autor:
Takayuki Morimoto, Tsutomu Nakazawa, Ryosuke Matsuda, Ryosuke Maeoka, Fumihiko Nishimura, Mitsutoshi Nakamura, Shuichi Yamada, Young-Soo Park, Takahiro Tsujimura, Ichiro Nakagawa
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 4, p 2435 (2024)
Despite standard multimodality treatment, containing maximum safety resection, temozolomide, radiotherapy, and a tumor-treating field, patients with glioblastoma (GBM) present with a dismal prognosis. Natural killer cell (NKC)-based immunotherapy wou
Externí odkaz:
https://doaj.org/article/e69d7435536e4836bf434d53e72855bc
Akademický článek
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Autor:
C. Mesas, R. Martínez, K. Doello, R. Ortiz, M. López-Jurado, Francisco Bermúdez, F. Quiñonero, J. Prados, J.M. Porres, C. Melguizo
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 149, Iss , Pp 112883- (2022)
Euphorbia lathyris seeds have been used to treat various medical conditions. We previously reported that ethanolic extract from the defatted seed of Euphorbia lathyris (EE) (variety S3201) possesses a potent in vitro antitumor activity against colon
Externí odkaz:
https://doaj.org/article/078c8d9aa1f849a1a93d809d4375238c
Development and optimization of orthotopic liver metastasis xenograft mouse models in uveal melanoma
Autor:
Takahito Sugase, Bao Q. Lam, Meggie Danielson, Mizue Terai, Andrew E. Aplin, J. Silvio Gutkind, Takami Sato
Publikováno v:
Journal of Translational Medicine, Vol 18, Iss 1, Pp 1-14 (2020)
Abstract Background Patients with metastatic uveal melanoma (MUM) in the liver usually die within 1 year. The development of new treatments for MUM has been limited by the lack of diverse MUM cell lines and appropriate animal models. We previously re
Externí odkaz:
https://doaj.org/article/40fa013f54d94e7fa6ce82bad4dece46
Akademický článek
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Akademický článek
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