Human bronchial carcinoid tumor initiating cells are targeted by the combination of acetazolamide and sulforaphane

Autor: Reza Bayat Mokhtari, Narges Baluch, Evgeniya Morgatskaya, Sushil Kumar, Angelo Sparaneo, Lucia Anna Muscarella, Sheyun Zhao, Hai-Ling Cheng, Bikul Das, Herman Yeger

Publikováno v: BMC Cancer, Vol 19, Iss 1, Pp 1-19 (2019)

Abstract Background Bronchial carcinoids are neuroendocrine tumors that present as typical (TC) and atypical (AC) variants, the latter being more aggressive, invasive and metastatic. Studies of tumor initiating cell (TIC) biology in bronchial carcino

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Human bronchial carcinoid tumor initiating cells are targeted by the combination of acetazolamide and sulforaphane.

Autor: Bayat Mokhtari R; Developmental and Stem Cell Biology Program, The Hospital for Sick Children, Toronto, ON, Canada. oncoplasia@gmail.com.; Department of Paediatric Laboratory Medicine, The Hospital for Sick Children, Toronto, ON, Canada. oncoplasia@gmail.com.; Institute of Medical Science, University of Toronto, Toronto, ON, Canada. oncoplasia@gmail.com.; The Hospital for Sick Children, Peter Gilgan Centre for Research and Learning, 686 Bay St., Rm 15.9714, Toronto, Ontario, M5G 0A4, Canada. oncoplasia@gmail.com., Baluch N; Department of Pediatrics, Queen's University, 76 Stuart St, Kingston, ON, K7L 2V7, Canada., Morgatskaya E; Developmental and Stem Cell Biology Program, The Hospital for Sick Children, Toronto, ON, Canada., Kumar S; Department of Pharmaceutical Sciences, College of Pharmacy, University of Nebraska Medical Center, Williams Science Hall 3035, Department of Pharmaceutical Sciences 601 S. Saddle Creek Rd, Omaha, NE, 68106, USA., Sparaneo A; Laboratory of Oncology, Fondazione IRCCS Casa Sollievo della Sofferenza, viale Cappuccini, 71013, San Giovanni Rotondo, FG, Italy., Muscarella LA; Laboratory of Oncology, Fondazione IRCCS Casa Sollievo della Sofferenza, viale Cappuccini, 71013, San Giovanni Rotondo, FG, Italy., Zhao S; Developmental and Stem Cell Biology Program, The Hospital for Sick Children, Toronto, ON, Canada., Cheng HL; Institute of Biomaterials & Biomedical Engineering, University of Toronto, 164 College Street, Rosebrugh Building, Room 407, Toronto, ON, M5S 3G9, Canada., Das B; Thoreau Laboratory for Global Health, M2D2, University of Massachusetts-Lowell, Innovation Hub, 110 Canal St, Lowell, MA, 01852, USA.; KaviKrishna Laboratory, Indian Institute of Technology Complex, Guwahati, India., Yeger H; Developmental and Stem Cell Biology Program, The Hospital for Sick Children, Toronto, ON, Canada.; Department of Paediatric Laboratory Medicine, The Hospital for Sick Children, Toronto, ON, Canada.; Institute of Medical Science, University of Toronto, Toronto, ON, Canada.; The Hospital for Sick Children, Peter Gilgan Centre for Research and Learning, 686 Bay St., Rm 15.9714, Toronto, Ontario, M5G 0A4, Canada.

Publikováno v: BMC cancer [BMC Cancer] 2019 Aug 30; Vol. 19 (1), pp. 864. Date of Electronic Publication: 2019 Aug 30.