Zobrazeno 1 - 10
of 58
pro vyhledávání: '"Orson L. Moritz"'
Autor:
Seyedeh Zeinab Mirjalili Mohanna, Jack W. Hickmott, Siu Ling Lam, Nina Y. Chiu, Tess C. Lengyell, Beatrice M. Tam, Orson L. Moritz, Elizabeth M. Simpson
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 17, Iss , Pp 478-490 (2020)
Aniridia is a rare eye disorder, which is caused by mutations in the paired box 6 (PAX6) gene and results in vision loss due to the lack of a long-term vision-saving therapy. One potential approach to treating aniridia is targeted CRISPR-based genome
Externí odkaz:
https://doaj.org/article/72def171bf954da9a10a19c51103507a
Autor:
Joanna M. Feehan, Colette N. Chiu, Paloma Stanar, Beatrice M. Tam, Sheikh N. Ahmed, Orson L. Moritz
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-14 (2017)
Abstract The utility of Xenopus laevis, a common research subject for developmental biology, retinal physiology, cell biology, and other investigations, has been limited by lack of a robust gene knockout or knock-down technology. Here we describe man
Externí odkaz:
https://doaj.org/article/ab62bec43fb74a4b8129521e5badc389
Autor:
Ishaq A. Viringipurampeer, Abu E. Bashar, Cheryl Y. Gregory-Evans, Orson L. Moritz, Kevin Gregory-Evans
Publikováno v:
International Journal of Inflammation, Vol 2013 (2013)
Genetic retinal diseases such as age-related macular degeneration and monogenic diseases such as retinitis pigmentosa account for some of the commonest causes of blindness in the developed world. Diverse genetic abnormalities and environmental causes
Externí odkaz:
https://doaj.org/article/630b48aac0fc4fc4872ae94b933bfc6a
Autor:
Anat Yanai, Urs O. Häfeli, Andrew L. Metcalfe, Peter Soema, Lois Addo, Cheryl Y. Gregory-Evans, Kelvin Po, Xianghong Shan, Orson L. Moritz, Kevin Gregory-Evans M.D., Ph.D., FRCS, FRCOphth.
Publikováno v:
Cell Transplantation, Vol 21 (2012)
Developing new ways of delivering cells to diseased tissue will be a key factor in translating cell therapeutics research into clinical use. Magnetically targeting cells enables delivery of significant numbers of cells to key areas of specific organs
Externí odkaz:
https://doaj.org/article/e6eff59ec5c2401e9ea92c965cf9153e
Publikováno v:
Journal of Translational Genetics and Genomics. 6:111-125
Aim: To examine the utility of gene editing therapies for retinitis pigmentosa using Xenopus laevis carrying a mutation in Rhodopsin. Methods: Xenopus laevis were genetically modified using CRISPR-Cas9 based methods and characterized by Sanger sequen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6499d47301614bc72c530eb19bb37e5a
https://doi.org/10.20517/jtgg.2021.49
https://doi.org/10.20517/jtgg.2021.49
Mutations in prominin-1 (prom1) and photoreceptor cadherin (cdhr1) are associated with inherited retinal degenerative disorders such as retinitis pigmentosa, cone-rod dystrophy, and juvenile macular dystrophy. The proteins encoded by these genes are
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8e651cfefd6bb81e3ea7bb3eff044604
https://doi.org/10.1101/2020.08.23.263780
https://doi.org/10.1101/2020.08.23.263780
Publikováno v:
Journal of Cell Science.
Mutations in prominin-1 (prom1) and photoreceptor cadherin (cdhr1) are associated with inherited retinal degenerative disorders but their functions remain unknown. We used CRISPR-Cas9 to generate prom1-, cdhr1-, and prom1+cdhr1-null X. laevis and the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::faba4fdf66034281a73b3550614ba457
https://doi.org/10.1242/jcs.253906
https://doi.org/10.1242/jcs.253906
Publikováno v:
Advances in experimental medicine and biology. 1185
We previously found that valproic acid (VPA) and other histone deacetylase inhibitors (HDACis) ameliorate retinal degeneration (RD) caused by P23H rhodopsin in Xenopus laevis larvae and hypothesized that this may be due to enhancement of autophagy. H
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::0ea4d4f9b964ef110aab01012c21a572
https://pubmed.ncbi.nlm.nih.gov/31884645
https://pubmed.ncbi.nlm.nih.gov/31884645
Publikováno v:
Advances in experimental medicine and biology. 1185
Retinal degenerative diseases are genetically diverse and rare inherited disorders that cause the death of rod and cone photoreceptors, resulting in progressive vision loss and blindness. This review will focus on two retinal degeneration-causing gen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::53b7969fcb8a346e8b385fb43f41d2bb
https://pubmed.ncbi.nlm.nih.gov/31884658
https://pubmed.ncbi.nlm.nih.gov/31884658
Autor:
Cheryl Y. Gregory-Evans, Andrew Metcalfe, Kevin Gregory-Evans, Ishaq A. Viringipurampeer, Emran Bashar, Orson L. Moritz
Publikováno v:
Molecular Neurobiology. 56:1637-1652
Retinitis pigmentosa (RP) is a group of inherited neurological disorders characterized by rod photoreceptor cell death, followed by secondary cone cell death leading to progressive blindness. Currently, there are no viable treatment options for RP. D
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a1c326d25fb3151f05285a5bc180a658
https://doi.org/10.1007/s12035-018-1192-8
https://doi.org/10.1007/s12035-018-1192-8