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Akademický článek

The antagonism of prostaglandin FP receptors inhibits the evolution of spreading depolarization in an experimental model of global forebrain ischemia

Autor: Dániel P. Varga, Írisz Szabó, Viktória É. Varga, Ákos Menhyárt, Orsolya M. Tóth, Mihály Kozma, Armand R. Bálint, István A. Krizbai, Ferenc Bari, Eszter Farkas

Publikováno v: Neurobiology of Disease, Vol 137, Iss , Pp 104780- (2020)

Spontaneous, recurrent spreading depolarizations (SD) are increasingly more appreciated as a pathomechanism behind ischemic brain injuries. Although the prostaglandin F2α - FP receptor signaling pathway has been proposed to contribute to neurodegene

Externí odkaz: https://doaj.org/article/6efcf2d2c8764928b483f90266b17668

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Akademický článek

Tissue Acidosis Associated with Ischemic Stroke to Guide Neuroprotective Drug Delivery

Autor: Orsolya M. Tóth, Ákos Menyhárt, Rita Frank, Dóra Hantosi, Eszter Farkas, Ferenc Bari

Publikováno v: Biology, Vol 9, Iss 12, p 460 (2020)

Ischemic stroke is a leading cause of death and disability worldwide. Yet, the effective therapy of focal cerebral ischemia has been an unresolved challenge. We propose here that ischemic tissue acidosis, a sensitive metabolic indicator of injury pro

Externí odkaz: https://doaj.org/article/5381d14e6a484df78b1029d6688b039a

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