Combined inhibition of EZH2 and ATM is synthetic lethal in BRCA1-deficient breast cancer

Autor: Leonie Ratz, Chiara Brambillasca, Leandra Bartke, Maxim A. Huetzen, Jonas Goergens, Orsolya Leidecker, Ron D. Jachimowicz, Marieke van de Ven, Natalie Proost, Bjørn Siteur, Renske de Korte-Grimmerink, Peter Bouwman, Emilia M. Pulver, Roebi de Bruijn, Jörg Isensee, Tim Hucho, Gaurav Pandey, Maarten van Lohuizen, Peter Mallmann, Hans Christian Reinhardt, Jos Jonkers, Julian Puppe

Publikováno v: Breast Cancer Research, Vol 24, Iss 1, Pp 1-19 (2022)

Abstract Background The majority of BRCA1-mutant breast cancers are characterized by a triple-negative phenotype and a basal-like molecular subtype, associated with aggressive clinical behavior. Current treatment options are limited, highlighting the

Externí odkaz: https://doaj.org/article/9766126bd94646d0abb634dc3e2d1caa

Serine is the major residue for ADP-ribosylation upon DNA damage

Autor: Luca Palazzo, Orsolya Leidecker, Evgeniia Prokhorova, Helen Dauben, Ivan Matic, Ivan Ahel

Publikováno v: eLife, Vol 7 (2018)

Poly(ADP-ribose) polymerases (PARPs) are a family of enzymes that synthesise ADP-ribosylation (ADPr), a reversible modification of proteins that regulates many different cellular processes. Several mammalian PARPs are known to regulate the DNA damage

Externí odkaz: https://doaj.org/article/1585b06cceda46c0884721dc94e68fa4

The ubiquitin-conjugating enzyme UBE2K determines neurogenic potential through histone H3 in human embryonic stem cells

Autor: David Vilchez, Prerana Wagle, Aniruddha Das, Alvaro Rada-Iglesias, Wojciech Pokrzywa, Alireza Noormohammadi, Orsolya Leidecker, Christina Schindler, Víctor Sánchez-Gaya, Markus M. Rinschen, Azra Fatima, Dilber Irmak, Thorsten Hoppe

Publikováno v: Communications Biology
Communications Biology, Vol 3, Iss 1, Pp 1-19 (2020)
Digital.CSIC. Repositorio Institucional del CSIC
instname

© The Author(s) 2020.
Histones modulate gene expression by chromatin compaction, regulating numerous processes such as differentiation. However, the mechanisms underlying histone degradation remain elusive. Human embryonic stem cells (hESCs) ha

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5b2cef67d2f7281d928384c8c8b43df7
https://doi.org/10.1038/s42003-020-0984-3

The Balance between Mono- and NEDD8-Chains Controlled by NEDP1 upon DNA Damage Is a Regulatory Module of the HSP70 ATPase Activity

Autor: Aurélien Perrin, Helene Trauchessec, Orsolya Leidecker, Aymeric P. Bailly, Chantal Maghames, Anton Gartner, Marina Serrano-Macia, Dimitris P. Xirodimas, María L. Martínez-Chantar

Publikováno v: Cell Reports
Cell Reports, 2019, 29 (1), pp.212-224.e8. ⟨10.1016/j.celrep.2019.08.070⟩
Cell Reports, Elsevier Inc, 2019, 29 (1), pp.212-224.e8. ⟨10.1016/j.celrep.2019.08.070⟩
Cell Reports, Vol 29, Iss 1, Pp 212-224.e8 (2019)

Summary Ubiquitin and ubiquitin-like chains are finely balanced by conjugating and de-conjugating enzymes. Alterations in this balance trigger the response to stress conditions and are often observed in pathologies. How such changes are detected is n

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d5d39ecc1dfd219f6cb99ac162e2d477
https://hal.umontpellier.fr/hal-02339558

An HPF1/PARP1-Based Chemical Biology Strategy for Exploring ADP-Ribosylation

Autor: Thomas Colby, Edoardo José Longarini, Helen Dauben, Pablo San Segundo-Acosta, Kathryn Perez, Ivan Matic, Juan José Bonfiglio, Orsolya Leidecker

Publikováno v: Cell

Strategies for installing authentic ADP-ribosylation (ADPr) at desired positions are fundamental for creating the tools needed to explore this elusive post-translational modification (PTM) in essential cellular processes. Here, we describe a phospho-

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e5e7e1b6fadac6b42b9adaae0b902735
https://doi.org/10.1016/j.cell.2020.09.055