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pro vyhledávání: '"Orsolya, Dohán"'
Akademický článek
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Publikováno v:
Archives of Endocrinology and Metabolism, Vol 67, Iss 2, Pp 256-261 (2023)
ABSTRACT Objective: The aim of this study was to investigate how polarized sodium iodide symporter (NIS) expression may regulate iodide metabolism in vivo. Materials and methods: Polarized NIS expression was analyzed in tissues that accumulate iodide
Externí odkaz:
https://doaj.org/article/5261d479daf34f30aaad51da50f9065f
Akademický článek
Tento výsledek nelze pro nepřihlášené uživatele zobrazit.
K zobrazení výsledku je třeba se přihlásit.
K zobrazení výsledku je třeba se přihlásit.
Autor:
Nancy Carrasco, Juan Pablo Nicola, Antonia Follenzi, Ekaterina Dadachova, Monika Paroder-Belenitsky, Matthew J. Maestas, Sepehr Eskandari, Orsolya Dohán, L. Mario Amzel, Andrea Reyna-Neyra
Publikováno v:
Proceedings of the National Academy of Sciences. 108:17933-17938
I - uptake in the thyroid, the first step in thyroid hormone biosynthesis, is mediated by the Na + /I - symporter (NIS) with an electrogenic 2Na + : 1I - stoichiometry. We have obtained mechanistic information on NIS by characterizing the congenital
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0ae7346c9933a02614804ff238bb5bc5
https://doi.org/10.1073/pnas.1108278108
https://doi.org/10.1073/pnas.1108278108
Autor:
G. Szilágyi, K. I. Takáts, I. Földes, János Földes, E. Rimanóczy, L. Kovács, A. Ferencz, Miklós Góth, Orsolya Dohán, István Szabolcs
Publikováno v:
Europe PubMed Central
The objective of the study was to investigate the efficacy of long term thyrostatic versus radioiodine treatment of hyperthyroidism in old age. Our study is a retrospective analysis of the therapeutical outcome in 66 patients over 60 years of age wit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3ae2bc6d0f4b645b2be78afe5ecdb703
https://doi.org/10.1055/s-0029-1212076
https://doi.org/10.1055/s-0029-1212076
Autor:
Orsolya Dohán, L. Mario Amzel, Nancy Carrasco, Cécile Basquin, Andrea Reyna-Neyra, Carla Portulano
Publikováno v:
Proceedings of the National Academy of Sciences. 104:20250-20255
The Na + /I − symporter (NIS) is a key plasma membrane protein that mediates active I − uptake in the thyroid, lactating breast, and other tissues with an electrogenic stoichiometry of 2 Na + per I − . In the thyroid, NIS-mediated I − uptake
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9ec477718aa744c627de78e049a6b968
https://doi.org/10.1073/pnas.0707207104
https://doi.org/10.1073/pnas.0707207104
Autor:
Michael L. Goris, Kent W. Nowels, Donna Adelman, Anthony Yudd, Nancy Carrasco, Irene Wapnir, Orsolya Dohán
Publikováno v:
Clinical Cancer Research. 10:4294-4302
Purpose: The Na+/I− symporter (NIS) is a key plasma membrane protein that mediates active iodide (I−) transport in the thyroid, lactating breast, and other tissues. Functional NIS expression in thyroid cancer accounts for the longstanding success
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::71b625298e444c6193118cf0bf18ede4
https://doi.org/10.1158/1078-0432.ccr-04-0074
https://doi.org/10.1158/1078-0432.ccr-04-0074
Autor:
Nancy Carrasco, Orsolya Dohán
Publikováno v:
Molecular and Cellular Endocrinology. 213:59-70
The Na(+)/I(-) symporter (NIS) is a plasma membrane glycoprotein that mediates active iodide uptake in the thyroid-the essential first step in thyroid hormone biosynthesis-and in other tissues, such as salivary and lactating mammary glands. Thyroidal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::634278239677b45521b5cc80be5d71ec
https://doi.org/10.1016/j.mce.2003.10.059
https://doi.org/10.1016/j.mce.2003.10.059
Publikováno v:
Trends in Biochemical Sciences. 26:490-496
The Na+/I- symporter (NIS) is an intrinsic plasma membrane protein that mediates the active transport of I- in the thyroid, lactating mammary gland, stomach and salivary glands. The presence of NIS in the thyroid is exploited in diagnostic scintigrap
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8e2c79bcc8fe2520973564af104e1d49
https://doi.org/10.1016/s0968-0004(01)01904-1
https://doi.org/10.1016/s0968-0004(01)01904-1
Autor:
Susan Fineberg, Hou Fu Deng, Peter S. Amenta, Qing Hua Zhao, Orlie Levy, Orsolya Dohán, Richard G. Pestell, Nancy Carrasco, Lionel S. Zuckier, Irene Wapnir, Uygar H. Tazebay
Publikováno v:
Nature Medicine. 6:871-878
The sodium/iodide symporter mediates active iodide transport in both healthy and cancerous thyroid tissue. By exploiting this activity, radioiodide has been used for decades with considerable success in the detection and treatment of thyroid cancer.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3bf47f1a109babb2f1c5e646b35eb3c6
https://doi.org/10.1038/78630
https://doi.org/10.1038/78630