Zobrazeno 1 - 10
of 61
pro vyhledávání: '"Orriss, I R"'
Autor:
Roberts, F L, Rashdan, N A, Phadwal, K, Markby, G R, Dillon, S, Zoll, J, Berger, J, Milne, E, Orriss, I R, Karsenty, G, Le Saux, O, Morton, N M, Farquharson, C, MacRae, V E
Supraphysiological levels of the osteoblast‐enriched mineralization regulator ectonucleotide pyrophosphatase or phosphodiesterase‐1 (NPP1) is associated with type 2 diabetes mellitus. We determined the impact of osteoblast‐specific Enpp1 ablati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=core_ac_uk__::bb97736122f32b866e9bde6f6895bc20
Autor:
Orriss, I R
Publikováno v:
BONE
Extracellular pyrophosphate (ePPi) was first identified as a key endogenous inhibitor of mineralisation in the 1960's by Fleisch and colleagues. The main source of ePPi seems to be extracellular ATP which is continually released from cells in a contr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=core_ac_uk__::0a360c4e6fd4232e61fc830995bc16d3
https://researchonline.rvc.ac.uk/id/eprint/12524/1/12524_Extracellular-pyrophosphate-The-bodys-water-softener_Accepted.pdf
https://researchonline.rvc.ac.uk/id/eprint/12524/1/12524_Extracellular-pyrophosphate-The-bodys-water-softener_Accepted.pdf
Autor:
Patel, J J, Bourne, L E, Davies, B K, Arnett, T R, MacRae, V E, Wheeler-Jones, C P D, Orriss, I R
Publikováno v:
Experimental Cell Research
Arterial medial calcification (AMC) is the deposition of calcium phosphate mineral, often as hydroxyapatite, in the medial layer of the arteries. AMC shares some similarities to skeletal mineralisation and has been associated with the transdifferenti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=core_ac_uk__::696276d68a2f82445ecc0f8d5cd954e7
https://researchonline.rvc.ac.uk/id/eprint/12031/1/12031.pdf
https://researchonline.rvc.ac.uk/id/eprint/12031/1/12031.pdf
Akademický článek
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Autor:
Orriss, I R, Lanham, S A, Savery, D, Greene, N D E, Stanier, P, Oreffo, R, Copp, A J, Galea, G L
Publikováno v:
Scientific Reports (Nature)
Fractures are a common comorbidity in children with the neural tube defect (NTD) spina bifida. Mutations in the Wnt/planar cell polarity (PCP) pathway contribute to NTDs in humans and mice, but whether this pathway independently determines bone mass
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=core_ac_uk__::7229b1c97bc0b90bbb22576d0fb092b5
https://researchonline.rvc.ac.uk/id/eprint/11237/1/11237.pdf
https://researchonline.rvc.ac.uk/id/eprint/11237/1/11237.pdf
Autor:
Arnett, T R, Orriss, I R
Publikováno v:
BONE
Osteoclasts are defined as cells capable of excavating 3-dimensional resorption pits in bone and other mineralised tissues. They are derived from the differentiation/fusion of promonocytic precursors, and are usually large, multinucleated cells. In c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=core_ac_uk__::a6ba84cd55349a24678d229b7b945fdf
https://researchonline.rvc.ac.uk/id/eprint/11145/1/11145.pdf
https://researchonline.rvc.ac.uk/id/eprint/11145/1/11145.pdf
Autor:
Patel, J J, Zhu, D, Opdebeeck, B, D'Haese, P, Millán, J L, Bourne, L E, Wheeler-Jones, C P D, Arnett, T R, MacRae, V E, Orriss, I R
Publikováno v:
Journal of Cellular Physiology
Arterial medial calcification (AMC) is thought to share some outward similarities to skeletal mineralization and has been associated with the transdifferentiation of vascular smooth muscle cells (VSMCs) to an osteoblast‐like phenotype. ATP and UTP
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=core_ac_uk__::36754cfb4e5b27c0448e6e117fdc9c00
https://researchonline.rvc.ac.uk/id/eprint/10972/1/10972.pdf
https://researchonline.rvc.ac.uk/id/eprint/10972/1/10972.pdf
Publikováno v:
JOURNAL OF ENDOCRINOLOGY
Bone cells constitutively release ATP into the extracellular environment where it acts locally via P2 receptors to regulate bone cell function. Whilst P2Y2 receptor stimulation regulates bone mineralisation, the functional effects of this receptor in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=core_ac_uk__::5314a53512ebb36a04157c50191844ab
https://researchonline.rvc.ac.uk/id/eprint/10758/1/10758.pdf
https://researchonline.rvc.ac.uk/id/eprint/10758/1/10758.pdf
Autor:
Orriss, I R, MacRae, V E
Publikováno v:
CURRENT OPINION IN PHARMACOLOGY
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=core_ac_uk__::de376b410aa0819f144eeb10edd10f22
https://researchonline.rvc.ac.uk/id/eprint/10126/1/10126.pdf
https://researchonline.rvc.ac.uk/id/eprint/10126/1/10126.pdf
Publikováno v:
CURRENT OPINION IN PHARMACOLOGY
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=core_ac_uk__::4f1bd258f3294ffb669d9f2bea61bd61
https://researchonline.rvc.ac.uk/id/eprint/10125/1/10125.pdf
https://researchonline.rvc.ac.uk/id/eprint/10125/1/10125.pdf