Zobrazeno 1 - 10
of 27
pro vyhledávání: '"Orrette R. Wauchope"'
Publikováno v:
Journal of Chemical Information and Modeling. 61:5589-5600
Here we report the testing and application of a simple, structure-aware framework to design target-specific screening libraries for drug development. Our approach combines advances in generative artificial intelligence (AI) with conventional molecula
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::60b29625c994e088f0efcb4315df374b
https://doi.org/10.1021/acs.jcim.1c00746
https://doi.org/10.1021/acs.jcim.1c00746
Publikováno v:
Organicbiomolecular chemistry. 18(45)
This review describes O2-dependent photoreactions for possible routes to double-bond isomerizations. E,Z-isomerizations triggered by O2 and visible light are a new area of potential synthetic interest. The reaction involves the reversible addition of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e8bde03578969a5bdd394fadf20e5412
https://pubmed.ncbi.nlm.nih.gov/33155598
https://pubmed.ncbi.nlm.nih.gov/33155598
Autor:
Kristie L. Rose, Philip J. Kingsley, David Spiegel, Matthew D. Streeter, Lawrence J. Marnett, Orrette R. Wauchope, Tina Wang, Michelle M. Mitchener, James A. Wepy, James J. Galligan, William N. Beavers
Publikováno v:
Proceedings of the National Academy of Sciences. 115:9228-9233
Histone posttranslational modifications (PTMs) regulate chromatin dynamics, DNA accessibility, and transcription to expand the genetic code. Many of these PTMs are produced through cellular metabolism to offer both feedback and feedforward regulation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::74bfd369a71f4838f3ac570f1a83f078
https://doi.org/10.1073/pnas.1802901115
https://doi.org/10.1073/pnas.1802901115
Autor:
Philip J. Kingsley, Thomas R. Blackwell, Lawrence J. Marnett, Ha-Na Shim, James J. Galligan, William D Sanders, Thong Luong, Mark deCaestecker, Jeannie M. Camarillo, William N. Beavers, Orrette R. Wauchope, Michelle M. Mitchener, Joshua P. Fessel
Publikováno v:
Nucleic Acids Research
Reactive oxygen species (ROS) are formed in mitochondria during electron transport and energy generation. Elevated levels of ROS lead to increased amounts of mitochondrial DNA (mtDNA) damage. We report that levels of M1dG, a major endogenous peroxida
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b1b5c891e8f51acd5d59e89ac1ddeb96
http://europepmc.org/articles/PMC5909422
http://europepmc.org/articles/PMC5909422
Autor:
Lawrence J. Marnett, William N. Beavers, Orrette R. Wauchope, Michelle M. Mitchener, Philip J. Kingsley, James J. Galligan
Publikováno v:
Chemical Research in Toxicology. 28:2334-2342
Chronic inflammation results in increased production of reactive oxygen species (ROS), which can oxidize cellular molecules including lipids and DNA. Our laboratory has shown that 3-(2-deoxy-β-d-erythro-pentofuranosyl)pyrimido[1,2-α]purin-10(3H)-on
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8bd55aa5adc73d6e8c0beeb90074f5ca
https://doi.org/10.1021/acs.chemrestox.5b00340
https://doi.org/10.1021/acs.chemrestox.5b00340
Autor:
Philip J. Kingsley, Irene Zagol-Ikapitte, Orrette R. Wauchope, Steven M. Shell, Walter J. Chazin, James J. Galligan, Carol A. Rouzer, William N. Beavers, John A. Oates, Olivier Boutaud, Norie Sugitani, Lawrence J. Marnett, Sarah C. Shuck, Kristie L. Rose
Publikováno v:
Chemical Research in Toxicology
Base propenals are products of the reaction of DNA with oxidants such as peroxynitrite and bleomycin. The most reactive base propenal, adenine propenal, is mutagenic in Escherichia coli and reacts with DNA to form covalent adducts; however, the react
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4e5c40f1f32ffc49645bd00acb7c58fe
https://doi.org/10.1021/tx500218g
https://doi.org/10.1021/tx500218g
Autor:
Jeannie M. Camarillo, Michelle M. Mitchener, James A. Wepy, James J. Galligan, Peter Harris, Lawrence J. Marnett, Kristofer S. Fritz, Philip J. Kingsley, Orrette R. Wauchope
Publikováno v:
Analytical chemistry. 89(2)
Post-translational modifications (PTMs) affect protein function, localization, and stability, yet very little is known about the ratios of these modifications. Here, we describe a novel method to quantitate and assess the relative stoichiometry of Ly
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8ac1ba858057762abf2be665b5f94b52
https://pubmed.ncbi.nlm.nih.gov/27982582
https://pubmed.ncbi.nlm.nih.gov/27982582
Autor:
Philip J. Kingsley, Kristie L. Rose, Lawrence J. Marnett, Tina Wang, William N. Beavers, David Spiegel, James J. Galligan, Matthew D. Streeter, Orrette R. Wauchope, Michelle M. Mitchener, James A. Wepy
Publikováno v:
Free Radical Biology and Medicine. 128:S137
Histone post-translational modifications (PTMs) regulate chromatin dynamics, DNA accessibility, and transcription to expand the genetic code. Many of these PTMs are produced through cellular metabolism to offer both feedback and feedforward regulatio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d752c185fca60f35dc9f9c1129a419cb
https://doi.org/10.1016/j.freeradbiomed.2018.10.362
https://doi.org/10.1016/j.freeradbiomed.2018.10.362
Autor:
Orrette R. Wauchope, Frank W. Grasso, Paul Haberfield, Nicola S. Farina, Mo Qi, Aaron T. Frank, Nahed Sawwan, Edyta M. Brzostowska, Alexander Greer, Wang Chan
Publikováno v:
Molecular Diversity. 11:115-118
This paper examines ring size patterns of natural product macrocycles. Evidence is presented that natural macrocycles containing 14-, 16-, and 18-membered rings are of frequent occurrence based on a data mining study. The results raise a question abo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::da4c7257cf8687bddc67265ee4e644ce
https://doi.org/10.1007/s11030-007-9065-5
https://doi.org/10.1007/s11030-007-9065-5
Publikováno v:
Journal of Sulfur Chemistry. 28:11-16
The ability of dibenzothiophene S-oxide (1) to photochemically induce strand breaks in plasmid DNA was studied under anaerobic conditions. DNA cleavage is monitored by the conversion of closed circular pUC19 DNA (form I) to the nicked (form II) and l
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4df7d60b94d59663516c7d3cb2c067ec
https://doi.org/10.1080/17415990601084457
https://doi.org/10.1080/17415990601084457