Zobrazeno 1 - 10
of 952
pro vyhledávání: '"Orphan G-Protein Coupled Receptor"'
Publikováno v:
Heliyon, Vol 10, Iss 7, Pp e28818- (2024)
G protein-coupled receptors (GPCRs), which form the largest family of membrane protein receptors in humans, are highly complex signaling systems with intricate structures and dynamic conformations and locations. Among these receptors, a specific subs
Externí odkaz:
https://doaj.org/article/8664ac655bd24cc2a4b601a507d7367c
Akademický článek
Tento výsledek nelze pro nepřihlášené uživatele zobrazit.
K zobrazení výsledku je třeba se přihlásit.
K zobrazení výsledku je třeba se přihlásit.
Akademický článek
Tento výsledek nelze pro nepřihlášené uživatele zobrazit.
K zobrazení výsledku je třeba se přihlásit.
K zobrazení výsledku je třeba se přihlásit.
Autor:
Andersson, Micaela
G-protein coupled receptors (GPCRs) play a key role in a broad range of biological processes by binding to a wide variety of signaling molecules, which have resulted in 34% of all FDA-approved drugs which target GPCRs. The human genome encodes for ap
Externí odkaz:
http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-186044
Publikováno v:
Cancers
Cancers, Vol 13, Iss 6136, p 6136 (2021)
Cancers, Vol 13, Iss 6136, p 6136 (2021)
Simple Summary Defining the specificity and biological sequalae induced by receptors differentiated expressed in multiple myeloma cells are critical for the development of effective immunotherapies based on monoclonal antibodies. Ongoing studies cont
Autor:
Yinan Liu, Yu Zhou, Housheng Hansen He, Mingkun Du, Yong Liu, Chuanfang Chen, Bao-Liang Song, Fangfang Han, Xiao Liu, Yan Wang
Publikováno v:
Cell Res
Autor:
Robert Newman, Benjamin G. Tehan, J.D. Brown, Richard Mould, Alicia P. Higueruelo, K.A. Bennett, O'brien Michael Alistair, Flavia Autore, Cliona MacSweeney, Heather Currinn, Cheryl A. Brighton, Lisa A. Stott, Steve P. Watson
Publikováno v:
Heliyon
Heliyon, Vol 7, Iss 6, Pp e07201-(2021)
Heliyon, Vol 7, Iss 6, Pp e07201-(2021)
The identification of cannabinoid ligands Cannabidiol and O-1918 as inverse agonists of the orphan receptor GPR52 is reported. Detailed characterisation of GPR52 pharmacology and modelling of the proposed receptor interaction is described. The identi
Autor:
Irmgard Tegeder
Publikováno v:
International Journal of Molecular Sciences, Vol 17, Iss 2, p 230 (2016)
Endocannabinoids including anandamide and 2-arachidonoylglycerol are involved in cancer pathophysiology in several ways, including tumor growth and progression, peritumoral inflammation, nausea and cancer pain. Recently we showed that the endocannabi
Externí odkaz:
https://doaj.org/article/d45a4b5a5c52428f9ad2d4770f82680e
Autor:
Sarah Tonack, Wencai Zhao, Stefan Günther, Harmandeep Kaur, Nadja Mößlein, Jorge Carvalho, Ramesh Chennupati, Michael Kurz, Nina Wettschureck, Moritz Bünemann, Rui Li, Stefan Offermanns
Publikováno v:
Circulation. 141(14)
Background: G protein–coupled receptors are important regulators of contractility and differentiation in vascular smooth muscle cells (SMCs), but the specific function of SMC-expressed orphan G protein–coupled receptor class C group 5 member B (G
Autor:
Dominik Thimm, Ivar von Kügelgen, Christa E. Müller, Gleice Borges, Thanigaimalai Pillaiyar, Vigneshwaran Namasivayam, Meryem Köse, Katharina Sylvester
Publikováno v:
ACS Omega, Vol 3, Iss 3, Pp 3365-3383 (2018)
ACS Omega
ACS Omega
GPR84, a Gi protein-coupled receptor that is activated by medium-chain (hydroxy)fatty acids, appears to play an important role in inflammation, immunity, and cancer. Recently, 6-octylaminouracil (4) has been reported to act as an agonist at GPR84. He