Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Orozco, Carolina T."'
Autor:
Robinson, Maximillian A., Kennedy, Alan, Orozco, Carolina T., Chen, Hung-Chang, Waters, Erin, Giovacchini, Dalisay, Yeung, Kay, Filer, Lily, Hinze, Claudia, Lloyd, Christopher, Dovedi, Simon J., Sansom, David M.
Publikováno v:
In Cell Reports 24 September 2024 43(9)
Autor:
Orozco, Carolina T, Bersellini, Manuela, Irving, Lorraine M, Howard, Wesley W, Hargreaves, David, Devine, Paul WA, Siouve, Elise, Browne, Gareth J, Bond, Nicholas J, Phillips, Jonathan J, Ravn, Peter, Jackson, Sophie E
Publikováno v:
mAbs. 14
Although monoclonal antibodies have greatly improved cancer therapy, they can trigger side effects due to on-target, off-tumor toxicity. Over the past decade, strategies have emerged to successfully mask the antigen-binding site of antibodies, such t
Autor:
Doyle, Lindsey A., Takushi, Brittany, Kibler, Ryan D., Milles, Lukas F., Orozco, Carolina T., Jones, Jonathan D., Jackson, Sophie E., Stoddard, Barry L., Bradley, Philip
Publikováno v:
Nature Communications; 10/24/2023, Vol. 14 Issue 1, p1-17, 17p
Autor:
Dannheim, Friederike M., Walsh, Stephen J., Orozco, Carolina T., Hansen, Anders Højgaard, Bargh, Jonathan D., Jackson, Sophie E., Bond, Nicholas J., Parker, Jeremy S., Carroll, Jason S., Spring, David R.
Publikováno v:
Chemical Science; 8/14/2022, Vol. 13 Issue 30, p8781-8790, 10p
Autor:
Robinson, Maximillian A., Kennedy, Alan, Orozco, Carolina T., Chen, Hung-Chang, Waters, Erin, Giovacchini, Dalisay, Yeung, Kay, Filer, Lily, Hinze, Claudia, Lloyd, Christopher, Dovedi, Simon J., Sansom, David M.
Publikováno v:
Cell Reports; September 2024, Vol. 43 Issue: 9
Autor:
Orozco, Carolina T., Edgeworth, Matthew J., Devine, Paul W. A., Hines, Alistair R., Cornwell, Owen, Thompson, Christopher, Wang, Xiangyang, Phillips, Jonathan J., Ravn, Peter, Jackson, Sophie E., Bond, Nicholas J.
Publikováno v:
Bioconjugate Chemistry; August 2021, Vol. 32 Issue: 8 p1834-1844, 11p
Autor:
Friederike M. Dannheim, Stephen J. Walsh, Carolina T. Orozco, Anders Højgaard Hansen, Jonathan D. Bargh, Sophie E. Jackson, Nicholas J. Bond, Jeremy S. Parker, Jason S. Carroll, David R. Spring
Publikováno v:
Dannheim, F M, Walsh, S J, Orozco, C T, Hansen, A H, Bargh, J D, Jackson, S E, Bond, N J, Parker, J S, Carroll, J S & Spring, D R 2022, ' All-in-one disulfide bridging enables the generation of antibody conjugates with modular cargo loading ', Chemical Science, vol. 13, 8781, pp. 8781-8790 . https://doi.org/10.1039/d2sc02198f
Antibody-drug conjugates (ADCs) are valuable therapeutic entities which leverage the specificity of antibodies to selectively deliver cytotoxins to antigen-expressing targets such as cancer cells. However, current methods for their construction still