Ligand-mediated protein degradation reveals functional conservation among sequence variants of the CUL4-type E3 ligase substrate receptor cereblon.

Autor: Akuffo AA; From the Department of Immunology.; the Cancer Biology Ph.D. Program, University of South Florida, Tampa, Florida 33612., Alontaga AY; From the Department of Immunology., Metcalf R; the Department of Chemistry and., Beatty MS; From the Department of Immunology., Becker A; the Chemical Biology Core, and., McDaniel JM; From the Department of Immunology., Hesterberg RS; From the Department of Immunology.; the Cancer Biology Ph.D. Program, University of South Florida, Tampa, Florida 33612., Goodheart WE; From the Department of Immunology., Gunawan S; the Department of Drug Discovery, Moffitt Cancer Center and Research Institute, Tampa, Florida 33612., Ayaz M; the Department of Drug Discovery, Moffitt Cancer Center and Research Institute, Tampa, Florida 33612., Yang Y; the Chemical Biology Core, and., Karim MR; the Department of Drug Discovery, Moffitt Cancer Center and Research Institute, Tampa, Florida 33612., Orobello ME; From the Department of Immunology., Daniel K; the Department of Chemistry and., Guida W; the Department of Chemistry and., Yoder JA; the Department of Molecular Biomedical Sciences, College of Veterinary Medicine, North Carolina State University, Raleigh, North Carolina 27607, and., Rajadhyaksha AM; Pediatric Neurology, Pediatrics, Brain and Mind Research Institute, Graduate Program in Neuroscience, Weill Cornell Medicine, Molecular and Developmental Neuroscience Laboratory, New York, New York 10065., Schönbrunn E; the Department of Drug Discovery, Moffitt Cancer Center and Research Institute, Tampa, Florida 33612., Lawrence HR; the Chemical Biology Core, and., Lawrence NJ; the Department of Drug Discovery, Moffitt Cancer Center and Research Institute, Tampa, Florida 33612., Epling-Burnette PK; From the Department of Immunology, Pearlie.Burnette@moffitt.org.

Publikováno v: The Journal of biological chemistry [J Biol Chem] 2018 Apr 20; Vol. 293 (16), pp. 6187-6200. Date of Electronic Publication: 2018 Feb 15.