Zobrazeno 1 - 10
of 1 196
pro vyhledávání: '"Ornithine decarboxylase antizyme"'
Autor:
Tao Wu, Jiale Xia, Feng Ge, Hao Qiu, Li Tian, Xiaotian Liu, Rui Liu, Ailiang Jiang, Jing Zhu, Liang Shi, Hanshou Yu, Mingwen Zhao, Ang Ren
Publikováno v:
Microbiology Spectrum, Vol 10, Iss 5 (2022)
ABSTRACT Putrescine (Put) has been shown to play an important regulatory role in cell growth in organisms. As the primary center regulating the homeostasis of polyamine (PA) content, ornithine decarboxylase antizyme (AZ) can regulate PA content throu
Externí odkaz:
https://doaj.org/article/86e42ae906dd4ed79f4bb9a9b325e9de
Publikováno v:
Electronic Journal of Biotechnology, Vol 26, Iss C, Pp 1-6 (2017)
Background: Ornithine decarboxylase antizyme 1 (OAZ1) is an important regulator of polyamine synthesis and uptake. Our previous studies indicated that high OAZ1 expression in the ovaries of laying geese is responsible for poor egg production. In the
Externí odkaz:
https://doaj.org/article/f611b1638dd84517864b0c7471e6f5d3
Akademický článek
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Autor:
James Campbell, Yordan Sbirkov, Amy Graham, Kevin Petrie, Colin Kwok, Karen Barker, Patrick M. Woster, Evon Poon, Zuzanna Urban-Wójciuk, Louis Chesler, Louise Howell
Publikováno v:
Cancer Gene Therapy. 29:940-950
Deregulated polyamine biosynthesis is emerging as a common feature of neuroblastoma and drugs targeting this metabolic pathway such as DFMO are in clinical and preclinical development. The polyamine analog verlindamycin inhibits the polyamine biosynt
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f7cf7a296409b6b2e70286cddbd77e6e
https://doi.org/10.1038/s41417-021-00386-6
https://doi.org/10.1038/s41417-021-00386-6
Publikováno v:
International Journal of Molecular Sciences; Volume 23; Issue 21; Pages: 12972
Polyamines are essential biogenic poly-cations with important roles in many cellular processes and diseases such as cancer. A rate-limiting step early in the biosynthesis of polyamines is the conversion of ornithine to putrescine by the homodimeric e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::14ba1c6524d76ca33225d3b38ce80dd0
Autor:
Chien-Yun Lee, Hui-Chih Hung, Chi-Li Lin, Ju-Yi Hsieh, Yi-Liang Liu, Guang-Yaw Liu, Yi-Fang Yang
Publikováno v:
Journal of Cellular Physiology. 236:5646-5663
This study reveals an uncovered mechanism for the regulation of polyamine homeostasis through protein arginyl citrullination of antizyme (AZ), a natural inhibitor of ornithine decarboxylase (ODC). ODC is critical for the cellular production of polyam
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f39d58758fb78d9a0ef06f4107825139
https://doi.org/10.1002/jcp.30252
https://doi.org/10.1002/jcp.30252
Publikováno v:
Journal of Biomolecular Structure and Dynamics. 39:5261-5275
Polyamine synthesis in human cells is initiated by catalytic action of Ornithine decarboxylase (ODC) on Ornithine. Elevated levels of polyamines are manifested proliferating cancer cells and are found to promote tumour cell adhesion. Di-flouro methyl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d116a66b35777f3fc2c46282cf644046
https://doi.org/10.1080/07391102.2020.1785331
https://doi.org/10.1080/07391102.2020.1785331
Autor:
Arif Sercan Şahutoğlu
Publikováno v:
Turkish Journal of Chemistry
Volume: 44, Issue: 3 817-832
Volume: 44, Issue: 3 817-832
Leucine decarboxylase LDC is a recently proposed enzyme with no official enzyme commission number yet. It is encoded by the Mus musculus gene Gm853 which is expressed at kidneys, generating isopentylamine, an alkylmonoamine that has not been describe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::08142ac2ad086b13cacb21fbd67ebacd
http://europepmc.org/articles/PMC7671201
http://europepmc.org/articles/PMC7671201
Autor:
Kodai Machida, Senya Matsufuji, Tomoaki Suzuki, Hiroaki Imataka, Takeo Iwamoto, Tomoaki Shigeta, Akihiro Oguro
Publikováno v:
The Journal of Biochemistry. 168:139-149
Antizyme (AZ) interacts with ornithine decarboxylase, which catalyzes the first step of polyamine biosynthesis and recruits it to the proteasome for degradation. Synthesizing the functional AZ protein requires transition of the reading frame at the t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::101e7da79a8893b99506d3a7a26fd631
https://doi.org/10.1093/jb/mvaa032
https://doi.org/10.1093/jb/mvaa032
Akademický článek
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