A New Antagonist of Caenorhabditis elegans Glutamate-Activated Chloride Channels With Anthelmintic Activity

Autor: María Julia Castro, Ornella Turani, María Belén Faraoni, Darío Gerbino, Cecilia Bouzat

Publikováno v: Frontiers in Neuroscience, Vol 14 (2020)

Nematode parasitosis causes significant mortality and morbidity in humans and considerable losses in livestock and domestic animals. The acquisition of resistance to current anthelmintic drugs has prompted the search for new compounds for which the f

Externí odkaz: https://doaj.org/article/30f7c496b5494307acb834a3337d212c

Caenorhabditis elegans muscle Cys-loop receptors as novel targets of terpenoids with potential anthelmintic activity

Autor: Ornella Turani, Guillermina Hernando, Cecilia Bouzat

Publikováno v: PLoS Neglected Tropical Diseases, Vol 13, Iss 11, p e0007895 (2019)
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PLoS Neglected Tropical Diseases

The anthelmintic treatment of nematode infections remains the pillar of worm control in both human and veterinary medicine. Since control is threatened by the appearance of drug resistant nematodes, there is a need to develop novel compounds, among w

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::79acf4f8f272a437569f53e94ea88651
https://journals.plos.org/plosntds/article?id=10.1371/journal.pntd.0007895

Activation of

Autor: Ornella, Turani, Guillermina, Hernando, Jeremías, Corradi, Cecilia, Bouzat

Publikováno v: Molecular pharmacology. 94(5)

Nicotinic acetylcholine receptors (nAChRs) are ligand-gated ion channels involved in neuromuscular transmission. In nematodes, muscle nAChRs are targets of antiparasitic drugs. Bephenium is an anthelmintic compound whose molecular action in the free-

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::3070a59190ec817995011da370418762
https://pubmed.ncbi.nlm.nih.gov/30190363

Caenorhabditis elegans muscle Cys-loop receptors as novel targets of terpenoids with potential anthelmintic activity.

Autor: Hernando, Guillermina¹ (AUTHOR), Turani, Ornella¹ (AUTHOR), Bouzat, Cecilia¹ (AUTHOR) inbouzat@criba.edu.ar

Publikováno v: PLoS Neglected Tropical Diseases. 11/25/2019, Vol. 13 Issue 11, p1-20. 20p.

Researchers from National University Sur Detail New Studies and Findings in the Area of Obesity, Fitness and Wellness (Regulation of Nicotinic Acetylcholine Receptors By Post-translational Modifications).

Publikováno v: Drug Week; 5/5/2023, p1627-1627, 1p