Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Ornella Randazzo"'
Autor:
I Gede Putu Supadmanaba, Giulia Mantini, Ornella Randazzo, Mjriam Capula, Ittai B. Muller, Stella Cascioferro, Patrizia Diana, Godefridus J. Peters, Elisa Giovannetti
Publikováno v:
Epigenetics, Vol 17, Iss 4, Pp 381-404 (2022)
Pancreatic ductal adenocarcinoma (PDAC) is one of the most lethal cancers because of diagnosis at late stage and inherent/acquired chemoresistance. Recent advances in genomic profiling and biology of this disease have not yet been translated to a rel
Externí odkaz:
https://doaj.org/article/95e67049e83d471fb22f4dea5968ac00
Autor:
Maria Valeria Raimondi, Ornella Randazzo, Mery La Franca, Giampaolo Barone, Elisa Vignoni, Daniela Rossi, Simona Collina
Publikováno v:
Molecules, Vol 24, Iss 6, p 1140 (2019)
Dihydrofolate reductase inhibitors are an important class of drugs, as evidenced by their use as antibacterial, antimalarial, antifungal, and anticancer agents. Progress in understanding the biochemical basis of mechanisms responsible for enzyme sele
Externí odkaz:
https://doaj.org/article/074b29da7a394448a0375d325f3de553
Autor:
Silvia Zoppi, Btissame El Hassouni, Godefridus J. Peters, Girolamo Cirrincione, Elisa Giovannetti, Andrea Cavazzoni, Daniela Carbone, Camilla Pecoraro, Giovanna Li Petri, Stella Cascioferro, Patrizia Diana, Ornella Randazzo, Barbara Parrino, Nadia Zaffaroni
Publikováno v:
Anticancer Research, 40(9), 4913-4919. International Institute of Anticancer Research
Petri, G L I, Pecoraro, C, Randazzo, O, Zoppi, S, Cascioferro, S M, Parrino, B, Carbone, D, Hassouni, B E L, Cavazzoni, A, Zaffaroni, N, Cirrincione, G, Diana, P, Peters, G J & Giovannetti, E 2020, ' New imidazo[2,1-b][1,3,4]thiadiazole aerivatives anhibit FAK phosphorylation and potentiate the antiproliferative effects of gemcitabine through modulation of the human equilibrative nucleoside transporter-1 in peritoneal mesothelioma ', Anticancer Research, vol. 40, no. 9, pp. 4913-4919 . https://doi.org/10.21873/anticanres.14494
Petri, G L I, Pecoraro, C, Randazzo, O, Zoppi, S, Cascioferro, S M, Parrino, B, Carbone, D, Hassouni, B E L, Cavazzoni, A, Zaffaroni, N, Cirrincione, G, Diana, P, Peters, G J & Giovannetti, E 2020, ' New imidazo[2,1-b][1,3,4]thiadiazole aerivatives anhibit FAK phosphorylation and potentiate the antiproliferative effects of gemcitabine through modulation of the human equilibrative nucleoside transporter-1 in peritoneal mesothelioma ', Anticancer Research, vol. 40, no. 9, pp. 4913-4919 . https://doi.org/10.21873/anticanres.14494
Background/aim A new class of imidazo[2,1-b][1,3,4]thiadiazole compounds have recently been evaluated as inhibitors of phosphorylation of focal adhesion kinase (FAK) in pancreatic cancer. FAK is overexpressed in mesothelioma and has recently emerged
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e01c41eda81084ed3059a1fcd5519282
https://doi.org/10.21873/anticanres.14494
https://doi.org/10.21873/anticanres.14494
Autor:
Godefridus J. Peters, Ugo Perricone, Ornella Randazzo, Elisa Giovannetti, Barbara Parrino, Patrizia Diana, Daniela Carbone, Stella Cascioferro, Camilla Pecoraro, Widad Ait Iddouch, Amir Avan
Publikováno v:
Cancer drug resistance (Alhambra, Calif.). 4(4)
Aim: Because mutations of splicing factor 3B subunit-1 (SF3B1) have been identified in 4% of pancreatic ductal adenocarcinoma (PDAC) patients, we investigated the activity of new potential inhibitors of SF3B1 in combination with gemcitabine, one of t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9ee65bdeec3aafae6459baec6c129649
https://pubmed.ncbi.nlm.nih.gov/35582381
https://pubmed.ncbi.nlm.nih.gov/35582381
Autor:
I Gede Putu Supadmanaba, Godefridus J. Peters, Patrizia Diana, Ornella Randazzo, Elisa Giovannetti, Ittai B. Muller, Stella Cascioferro, Giulia Mantini, M. Capula
Publikováno v:
Supadmanaba, I G P, Mantini, G, Randazzo, O, Capula, M, Muller, I B, Cascioferro, S, Diana, P, Peters, G J & Giovannetti, E 2021, ' Interrelationship between miRNA and splicing factors in pancreatic ductal adenocarcinoma ', Epigenetics . https://doi.org/10.1080/15592294.2021.1916697
Epigenetics. Landes Bioscience
Epigenetics. Landes Bioscience
Pancreatic ductal adenocarcinoma (PDAC) is one of the most lethal cancers because of diagnosis at late stage and inherent/acquired chemoresistance. Recent advances in genomic profiling and biology of this disease have not yet been translated to a rel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1bff33954e1087a9bc2b5999f81db612
http://hdl.handle.net/10447/533772
http://hdl.handle.net/10447/533772
Autor:
Elisa Giovannetti, Stella Cascioferro, Daniel S. K. Liu, Daniela Carbone, Ingrid Garajová, Filippo Papini, Adam E Frampton, Barbara Parrino, Alessandro Gregori, Godefridus J. Peters, Ornella Randazzo, Giulia Mantini
Publikováno v:
Cancers
Volume 12
Issue 11
Randazzo, O, Papini, F, Mantini, G, Gregori, A, Parrino, B, Liu, D S K, Cascioferro, S, Carbone, D, Peters, G J, Frampton, A E, Garajova, I & Giovannetti, E 2020, ' “Open sesame?”: Biomarker status of the human equilibrative nucleoside transporter-1 and molecular mechanisms influencing its expression and activity in the uptake and cytotoxicity of gemcitabine in pancreatic cancer ', Cancers, vol. 12, no. 11, 3206, pp. 1-20 . https://doi.org/10.3390/cancers12113206
Cancers, 12(11):3206, 1-20. Multidisciplinary Digital Publishing Institute (MDPI)
Cancers, Vol 12, Iss 3206, p 3206 (2020)
Volume 12
Issue 11
Randazzo, O, Papini, F, Mantini, G, Gregori, A, Parrino, B, Liu, D S K, Cascioferro, S, Carbone, D, Peters, G J, Frampton, A E, Garajova, I & Giovannetti, E 2020, ' “Open sesame?”: Biomarker status of the human equilibrative nucleoside transporter-1 and molecular mechanisms influencing its expression and activity in the uptake and cytotoxicity of gemcitabine in pancreatic cancer ', Cancers, vol. 12, no. 11, 3206, pp. 1-20 . https://doi.org/10.3390/cancers12113206
Cancers, 12(11):3206, 1-20. Multidisciplinary Digital Publishing Institute (MDPI)
Cancers, Vol 12, Iss 3206, p 3206 (2020)
Simple Summary Despite the enormous advance in biomarker discovery, many potential biomarkers of drug activity are unable to satisfy the clinical need due to inadequate sensitivity and specificity. The nucleoside transporter hENT-1 has been studied a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::353a491d985e5bdbe0eead93b64a847d
http://hdl.handle.net/10044/1/85074
http://hdl.handle.net/10044/1/85074
Autor:
Giovanna, Li Petri, Camilla, Pecoraro, Ornella, Randazzo, Silvia, Zoppi, Stella Maria, Cascioferro, Barbara, Parrino, Daniela, Carbone, Btissame, El Hassouni, Andrea, Cavazzoni, Nadia, Zaffaroni, Girolamo, Cirrincione, Patrizia, Diana, Godefridus J, Peters, Elisa, Giovannetti
Publikováno v:
Anticancer research. 40(9)
A new class of imidazo[2,1-b][1,3,4]thiadiazole compounds have recently been evaluated as inhibitors of phosphorylation of focal adhesion kinase (FAK) in pancreatic cancer. FAK is overexpressed in mesothelioma and has recently emerged as an interesti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::4c6c51da6dac6046f7c032761ed108b8
https://pubmed.ncbi.nlm.nih.gov/32878779
https://pubmed.ncbi.nlm.nih.gov/32878779
Autor:
Daniela Rossi, Ornella Randazzo, Elisa Vignoni, Giampaolo Barone, Simona Collina, Mery La Franca, Maria Valeria Raimondi
Publikováno v:
Molecules
Molecules, Vol 24, Iss 6, p 1140 (2019)
Molecules, Vol 24, Iss 6, p 1140 (2019)
Dihydrofolate reductase inhibitors are an important class of drugs, as evidenced by their use as antibacterial, antimalarial, antifungal, and anticancer agents. Progress in understanding the biochemical basis of mechanisms responsible for enzyme sele
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d787373a62a04626c8de4c477e476e6a
https://pubmed.ncbi.nlm.nih.gov/30909399
https://pubmed.ncbi.nlm.nih.gov/30909399
Autor:
LA FRANCA, M., Ornella, R., Plescia, F., Maggio, B., Daidone, G., Raffa, D., LI PETRI, G., Roberta, L., Agnese, R., Barone, G., Raimondi, M.
I chinazolinoni sono composti eterociclici azotati che, insieme alle chinazoline, rappresentano degli importanti farmacofori in possesso di un ampio spettro di proprietà biologiche tra cui quella antitumorale. Recentemente sono stati riportati in le
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::cb3c7b3f5e20bdf62fb208b2eaecab62
http://hdl.handle.net/10447/272585
http://hdl.handle.net/10447/272585
Autor:
Roberta, L., Cusimano, M., Plescia, F., Maggio, B., Daidone, G., Raffa, D., LA FRANCA, M., LI PETRI, G., Agnese, R., Ornella, R., Barone, G., Schillaci, D., Raimondi, M.
La Sortasi A è un enzima di membrana responsabile dell’ancoraggio delle proteine di superficie sulla parete cellulare dei batteri Gram-positivi. Essa è considerata un interessante obiettivo per lo sviluppo di nuovi farmaci anti-infettivi che miri
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::9ab7bbefc978664679d640643cfd2848
http://hdl.handle.net/10447/272600
http://hdl.handle.net/10447/272600