Zobrazeno 1 - 10
of 29
pro vyhledávání: '"Ornella Letari"'
Autor:
Gianfranco Caselli, Albino Bonazzi, Marco Lanza, Flora Ferrari, Daniele Maggioni, Cristian Ferioli, Roberto Giambelli, Eleonora Comi, Silvia Zerbi, Marco Perrella, Ornella Letari, Elena Di Luccio, Milena Colovic, Stefano Persiani, Tiziano Zanelli, Laura Mennuni, Tiziana Piepoli, Lucio Claudio Rovati
Publikováno v:
Arthritis Research & Therapy, Vol 20, Iss 1, Pp 1-19 (2018)
Abstract Background Prostaglandin E2 (PGE2) acts via its EP4 receptor as a cytokine amplifier (e.g., interleukin [IL]-6) and induces the differentiation and expansion of inflammatory T-helper (Th) lymphocytes. These mechanisms play a key role in the
Externí odkaz:
https://doaj.org/article/22fc8ca4e2234150b60717587ab81196
Autor:
Tiziana Piepoli, Chiara Galimberti, Silvia Zerbi, Gianfranco Caselli, Roberto Artusi, Ornella Letari, Giuseppe M. Montagna, Milena Colovic, Stefano Persiani, Lucio C. Rovati
Publikováno v:
Cancer Research. 80:4219-4219
BACKGROUND: Currently there is no cure for glioblastoma (GBM), the most malignant primary brain cancer. Glioblastoma etiopathogenesis involves mutations and alterations of key signaling pathways including tyrosine kinases (TKs). Notably, aberrant act
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f8c81f63475de9c7b7e402dc363b38ee
https://doi.org/10.1158/1538-7445.am2020-4219
https://doi.org/10.1158/1538-7445.am2020-4219
Autor:
Chiara Sabatini, Lucio C. Rovati, Chiara Giacomoni, Gianfranco Caselli, Ornella Letari, Marco Lanza, Vittorio Vellani, Chiara Milia
Publikováno v:
Br J Pharmacol
BACKGROUND AND PURPOSE: CR4056 is a first‐in‐class imidazoline‐2 (I(2)) receptor ligand characterized by potent analgesic activity in different experimental animal models of pain. In a recent phase II clinical trial, CR4056 effectively reduced
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d7c22e7e9bd3fe3cfb3f109066cf4c99
https://pubmed.ncbi.nlm.nih.gov/31454418
https://pubmed.ncbi.nlm.nih.gov/31454418
Autor:
Ornella Letari, Benedetta Buzzi, Paolo Garofalo, Luigi Piero Stasi, Luca Canciani, Gianfranco Caselli, Fabrizio Colace, Roberto Artusi, Matteo Salvi, Clara Bovino, Patrice Larger, Stefano Mandelli, Lorenzo Perugini, Silvia Giambuzzi, Sabrina Pucci, PierLuigi Toro
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 23:2653-2658
Starting from a orexin 1 receptor selective antagonist 4,4-disubstituted piperidine series a novel potent 5-azaspiro[2.4]heptane dual orexin 1 and orexin 2 receptor antagonist class has been discovered. SAR and Pharmacokinetic optimization of this se
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::45f102f2b13ddd11878c94ed47b63421
https://doi.org/10.1016/j.bmcl.2013.02.093
https://doi.org/10.1016/j.bmcl.2013.02.093
Autor:
Norberto Oggioni, Annalisa Canta, Flora Ferrari, Cristina Meregalli, Marco Lanza, Guido Cavaletti, B Sala, Paola Marmiroli, Valentina Alda Carozzi, Cecilia Ceresa, Ornella Letari, Gianfranco Caselli, Alessia Chiorazzi, F Avezza
Publikováno v:
Journal of Pain Research, Vol 2012, Iss default, Pp 151-167 (2012)
Journal of Pain Research
Journal of Pain Research
Cristina Meregalli,1 Cecilia Ceresa,1 Annalisa Canta,1 Valentina Alda Carozzi,1 Alessia Chiorazzi,1 Barbara Sala,1 Norberto Oggioni,1 Marco Lanza,2 Ornella Letar,i2 Flora Ferrari,2 Federica Avezza,1 Paola Marmiroli,1 GianFranco Caselli,2 Guido Cavale
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3228dcefc3511cff760e6225fc2aa932
http://www.dovepress.com/cr4056-a-new-analgesic-i2-ligand-is-highly-effective-against-bortezomi-a10174
http://www.dovepress.com/cr4056-a-new-analgesic-i2-ligand-is-highly-effective-against-bortezomi-a10174
Autor:
Albino Bonazzi, Lucio C. Rovati, Ornella Letari, Catherine Booth, Francesco Makovec, Gianfranco Caselli, Paolo Garofalo
Publikováno v:
Cancer Chemotherapy and Pharmacology
Purpose Gastrointestinal mucositis, commonly associated with diarrhea, is a dose-limiting toxicity of chemotherapy. The new benzamidine derivative CR3294 reduces tissue damage in animal models of intestinal inflammation. Thus, we tested whether CR329
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::590d4f3af1e957edcc95037478c96cb5
https://doi.org/10.1007/s00280-009-1224-1
https://doi.org/10.1007/s00280-009-1224-1
Publikováno v:
European Journal of Pharmacology. 369:81-90
The antigastrinic, antisecretory and antiulcer activities of CR 2945, (R)-1-naphthalenepropanoic acid,beta-[2-[[2-(8-azaspiro[4.5]dec-8-yl-carbonyl)-4,6-dimethylph enyl] amino]-2-oxoethyl], were investigated in vitro and in vivo in rats and cats. Its
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2f660dbd969be7dc313d6e748cbb6d12
https://doi.org/10.1016/s0014-2999(99)00069-2
https://doi.org/10.1016/s0014-2999(99)00069-2
Publikováno v:
Biochemical Journal. 325:71-77
The internalization of [3H]iloprost, a prostacyclin analogue, was studied in human platelets by binding studies. After incubation with [3H]iloprost at 37 degrees C, addition of unlabelled ligand at either 37 degrees C or 4 degrees C caused dissociati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::962ac3346abde4030be9ed5c22b035ab
https://doi.org/10.1042/bj3250071
https://doi.org/10.1042/bj3250071
Autor:
Gianluca Giorgi, Laura Mennuni, Antonio Giordani, Sandra Gemma, Maurizio Anzini, Germano Giuliani, Giuseppe Campiani, Francesco Makovec, Marco Lanza, Simone Brogi, Ornella Letari, Federica Castriconi, Gianfranco Caselli, Monica Manini, Stefania Butini, Salvatore Valenti, Andrea Cappelli
A new class of serotonin 5-HT1A receptor ligands related to NAN-190, buspirone and aripiprazole has been designed using our potent 5-HT3 receptor ligands as templates. The designed pyrrolidone derivatives 10a-n were prepared by means of the straightf
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9bd25da368337173fff64ebfa08ac5d7
http://hdl.handle.net/11568/993604
http://hdl.handle.net/11568/993604
Autor:
Gianfranco Caselli, Flora Ferrari, Antonio Giordani, Ornella Letari, Simonetta Fiorentino, Paolo Garofalo, Laura Mennuni, Stefano Mandelli, Marco Lanza
Publikováno v:
Journal of Pain Research, Vol 2011, Iss default, Pp 111-125 (2011)
Journal of Pain Research
Journal of Pain Research
Flora Ferrari1, Simonetta Fiorentino1, Laura Mennuni1, Paolo Garofalo1, Ornella Letari1, Stefano Mandelli2, Antonio Giordani3, Marco Lanza1, Gianfranco Caselli11Department of Pharmacology and Toxicology; 2Department of Medicinal Chemistry; 3R&D Chemi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6c555a4e16e53990c369e6fb5a5509d8
https://www.dovepress.com/analgesic-efficacy-of-cr4056-a-novel-imidazoline-2-receptor-ligand-in--peer-reviewed-article-JPR
https://www.dovepress.com/analgesic-efficacy-of-cr4056-a-novel-imidazoline-2-receptor-ligand-in--peer-reviewed-article-JPR