Zobrazeno 1 - 10
of 69
pro vyhledávání: '"Ornella Franzese"'
Autor:
Ornella Franzese, Belinda Palermo, Giuseppe Frisullo, Mariangela Panetta, Giulia Campo, Daniel D’Andrea, Isabella Sperduti, Riccardo Taje, Paolo Visca, Paola Nisticò
Publikováno v:
OncoImmunology, Vol 13, Iss 1 (2024)
Improving cancer immunotherapy efficacy hinges on identifying key T-cell populations critical for tumor control and response to Immune Checkpoint Blockade (ICB). We have recently reported that while the co-expression of PD-1 and CD28 is associated wi
Externí odkaz:
https://doaj.org/article/4a3fe000f0ec40e5ac1a176751a5d0fd
Autor:
Belinda Palermo, Ornella Franzese, Giuseppe Frisullo, Lorenzo D’Ambrosio, Mariangela Panetta, Giulia Campo, Daniel D’Andrea, Isabella Sperduti, Francesca De Nicola, Frauke Goeman, Filippo Gallina, Paolo Visca, Francesco Facciolo, Paola Nisticò
Publikováno v:
Journal of Experimental & Clinical Cancer Research, Vol 42, Iss 1, Pp 1-26 (2023)
Abstract Background Immune checkpoint blockade (ICB) has significantly prolonged survival of non-small cell lung cancer (NSCLC) patients, although most patients develop mechanisms of resistance. Recently single-cell RNA-sequencing (scRNA-Seq) reveale
Externí odkaz:
https://doaj.org/article/571ea82633d4428bb111cb168f3d2393
Publikováno v:
Cells, Vol 13, Iss 11, p 924 (2024)
Induction of apoptosis represents a promising therapeutic approach to drive tumor cells to death. However, this poses challenges due to the intricate nature of cancer biology and the mechanisms employed by cancer cells to survive and escape immune su
Externí odkaz:
https://doaj.org/article/9f6b08f50d03410194dea01aa223becd
Publikováno v:
Journal of Experimental & Clinical Cancer Research, Vol 41, Iss 1, Pp 1-16 (2022)
Abstract Profiling the T-Cell Receptor (TCR) repertoire is establishing as a potent approach to investigate autologous and treatment-induced antitumor immune response. Technical and computational breakthroughs, including high throughput next-generati
Externí odkaz:
https://doaj.org/article/829ea4156d994194b368ba84cb9bcea9
Publikováno v:
Biology, Vol 12, Iss 8, p 1047 (2023)
The frequent PKC dysregulations observed in many tumors have made these enzymes natural targets for anticancer applications. Nevertheless, this considerable interest in the development of PKC modulators has not led to the expected therapeutic benefit
Externí odkaz:
https://doaj.org/article/83d1594d430b47d1a2505ef921100fcb
Autor:
Ornella Franzese, Grazia Graziani
Publikováno v:
Cancers, Vol 14, Iss 22, p 5633 (2022)
Poly (ADP-ribose) polymerase (PARP) inhibitors (PARPi) induce cytotoxic effects as single agents in tumors characterized by defective repair of DNA double-strand breaks deriving from BRCA1/2 mutations or other abnormalities in genes associated with h
Externí odkaz:
https://doaj.org/article/686eb9870e5b4c7494b942612292c206
Autor:
Ornella Franzese, Francesco Torino, Elisa Giannetti, Giorgia Cioccoloni, Angelo Aquino, Isabella Faraoni, Maria Pia Fuggetta, Liana De Vecchis, Anna Giuliani, Bernd Kaina, Enzo Bonmassar
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 19, p 10672 (2021)
The current state of cancer treatment is still far from being satisfactory considering the strong impairment of patients’ quality of life and the high lethality of malignant diseases. Therefore, it is critical for innovative approaches to be tested
Externí odkaz:
https://doaj.org/article/b766fa0356a34df495a57f3eb59225ef
Autor:
Belinda Palermo, Ornella Franzese, Cosmo Di Donna, Mariangela Panetta, Concetta Quintarelli, Isabella Sperduti, Novella Gualtieri, Maria Laura Foddai, Enrico Proietti, Virginia Ferraresi, Gennaro Ciliberto, Paola Nisticò
Publikováno v:
OncoImmunology, Vol 7, Iss 12 (2018)
We have recently described that DNA-damage inducing drug DTIC, administered before peptide (Melan-A and gp100)-vaccination, improves anti-tumor CD8+ Melan-A-specific T-cell functionality, enlarges the Melan-A+ TCR repertoire and impacts the overall s
Externí odkaz:
https://doaj.org/article/68373cd86cff4bdc93b8465e055a25a6
Autor:
Angelo Aquino, Grazia Graziani, Ornella Franzese, Salvatore P. Prete, Enzo Bonmassar, Laura Bonmassar, Stefania D'Atri
Publikováno v:
Clinical and Developmental Immunology, Vol 2011 (2011)
Group I CD1 (CD1a, CD1b, and CD1c) glycoproteins expressed on immature and mature dendritic cells present nonpeptide antigens (i.e., lipid or glycolipid molecules mainly of microbial origin) to T cells. Cytotoxic CD1-restricted T lymphocytes recogniz
Externí odkaz:
https://doaj.org/article/bc6400e23ad345d6b4d1c1096fbf0582
Autor:
Angela Maria Di Francesco, Riccardo Riccardi, Gabriella Cusano, Antonio Ruggiero, Lauretta Levati, Ornella Franzese, Grazia Graziani, Daniela Meco
Publikováno v:
Pathology and Oncology Research
The neurotrophin nerve growth factor (NGF) modulates the growth of human gliomas and is able to induce cell differentiation through the engagement of tropomyosin receptor kinase A (TrkA) receptor, although the role played in controlling glioma surviv