Zobrazeno 1 - 10
of 33
pro vyhledávání: '"Ornella Affinito"'
Autor:
Ornella Affinito, Francesca Maria Orlandella, Neila Luciano, Marco Salvatore, Giuliana Salvatore, Monica Franzese
Publikováno v:
Cancer Cell International, Vol 22, Iss 1, Pp 1-20 (2022)
Abstract Background Intra-tumor heterogeneity (ITH) results from the continuous accumulation of mutations during disease progression, thus impacting patients’ clinical outcome. How the ITH evolves across papillary thyroid carcinoma (PTC) different
Externí odkaz:
https://doaj.org/article/f642941af3ef4897ae91d2b6441d5b25
Autor:
Teresa Infante, Monica Franzese, Antonio Ruocco, Concetta Schiano, Ornella Affinito, Katia Pane, Domenico Memoli, Francesca Rizzo, Alessandro Weisz, Paola Bontempo, Vincenzo Grimaldi, Liberato Berrino, Andrea Soricelli, Ciro Mauro, Claudio Napoli
Publikováno v:
Epigenetics, Vol 17, Iss 5, Pp 547-563 (2022)
Acute coronary syndrome (ACS) is the most severe clinical manifestation of coronary heart disease. We performed an epigenome-wide analysis of circulating CD4+ and CD8+ T cells isolated from ACS patients and healthy subjects (HS), enrolled in the DIAN
Externí odkaz:
https://doaj.org/article/91ad99c7794d4348aa5cd12448a31186
Autor:
Mario Zanfardino, Rossana Castaldo, Katia Pane, Ornella Affinito, Marco Aiello, Marco Salvatore, Monica Franzese
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-13 (2021)
Abstract Analysis of large-scale omics data along with biomedical images has gaining a huge interest in predicting phenotypic conditions towards personalized medicine. Multiple layers of investigations such as genomics, transcriptomics and proteomics
Externí odkaz:
https://doaj.org/article/d32c69fb74104e7a9b69643e62d5c3f7
Publikováno v:
Diagnostics, Vol 12, Iss 10, p 2452 (2022)
The biological function and clinical values of Chromobox (CBX) family proteins in renal cell carcinoma (RCC) are still poorly investigated. This study aimed to compare the expression profiles and clinical relevance of CBXs between the two most freque
Externí odkaz:
https://doaj.org/article/b5de4140ae3445fd99a4471158412165
Autor:
Katia Pane, Ornella Affinito, Mario Zanfardino, Rossana Castaldo, Mariarosaria Incoronato, Marco Salvatore, Monica Franzese
Publikováno v:
Frontiers in Genetics, Vol 11 (2020)
Breast, ovarian, and endometrial cancers have a major impact on mortality in women. These tumors share hormone-dependent mechanisms involved in female-specific cancers which support tumor growth in a different manner. Integrated computational approac
Externí odkaz:
https://doaj.org/article/11a9531488b64b0aacbd1361511973df
Publikováno v:
BMC Genomics, Vol 19, Iss 1, Pp 1-9 (2018)
Abstract Background In recent years, epigenetics has gained a central role in the understanding of the process of natural selection. It is now clear how environmental impacts on the methylome could promote methylation variability with direct effects
Externí odkaz:
https://doaj.org/article/594edfb5f6194a92a4e54862a3f82741
Autor:
Elena Montano, Alessandra Pollice, Valeria Lucci, Geppino Falco, Ornella Affinito, Girolama La Mantia, Maria Vivo, Tiziana Angrisano
Publikováno v:
Biomolecules, Vol 11, Iss 8, p 1124 (2021)
The identification of the molecular mechanisms controlling early cell fate decisions in mammals is of paramount importance as the ability to determine specific lineage differentiation represents a significant opportunity for new therapies. Pancreatic
Externí odkaz:
https://doaj.org/article/355e40e1e1b2423cbb4f6a90c5b928d9
Autor:
Ermanno Florio, Simona Keller, Lorena Coretti, Ornella Affinito, Giovanni Scala, Francesco Errico, Annalisa Fico, Francesca Boscia, Maria Josè Sisalli, Mafalda Giovanna Reccia, Gennaro Miele, Antonella Monticelli, Antonella Scorziello, Francesca Lembo, Luca Colucci-D'Amato, Gabriella Minchiotti, Vittorio Enrico Avvedimento, Alessandro Usiello, Sergio Cocozza, Lorenzo Chiariotti
Publikováno v:
Epigenetics, Vol 12, Iss 1, Pp 41-54 (2017)
We performed ultra-deep methylation analysis at single molecule level of the promoter region of developmentally regulated D-Aspartate oxidase (Ddo), as a model gene, during brain development and embryonic stem cell neural differentiation. Single mole
Externí odkaz:
https://doaj.org/article/a9478b179b47438f8014f2f51a8cedd1
Publikováno v:
PLoS ONE, Vol 9, Iss 12, p e114432 (2014)
The regions surrounding transcription start sites (TSSs) of genes play a critical role in the regulation of gene expression. At the same time, current evidence indicates that these regions are particularly stressed by transcription-related mutagenic
Externí odkaz:
https://doaj.org/article/f3b885a820b941b3ab61be917182d3e1
Autor:
Giuditta Benincasa, Bradley A. Maron, Ornella Affinito, Michele D’Alto, Monica Franzese, Paola Argiento, Concetta Schiano, Emanuele Romeo, Paola Bontempo, Paolo Golino, Liberato Berrino, Joseph Loscalzo, Claudio Napoli
Publikováno v:
Journal of Cardiovascular Translational Research. 16:17-30
Pathogenic DNA methylation changes may be involved in pulmonary arterial hypertension (PAH) onset and its progression, but there is no data on potential associations with patient-derived hemodynamic parameters. The reduced representation bisulfite se