Zobrazeno 1 - 10
of 51
pro vyhledávání: '"Orna Tighe"'
Autor:
Gianpiero L. Cavalleri, Steven W. Kerrigan, Tracy Robson, Judith Strawbridge, Michelle Flood, Fiona O'Brien, Róisín Reynolds, Shane Cullinan, Orna Tighe, Brian P. Kirby, Anne Teresa Morgan, John C. Hayden, James W. Barlow, Anthony Maher, Matthew Lynch
Publikováno v:
Research in Social & Administrative Pharmacy
The impact of the COVID-19 pandemic on pharmacy education worldwide has been immense, affecting students, educators and regulatory agencies. Pharmacy programmes have had to rapidly adapt in their delivery of education, maintaining standards while als
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ceba54a4c14a8543536ca7ea9529a4db
http://europepmc.org/articles/PMC8367658
http://europepmc.org/articles/PMC8367658
Autor:
Emilie Petit, Clare O’Leary, Orna Tighe, John L. Waddington, Steve Wilson, Lieve Desbonnet, Colm M. P. O’Tuathaigh, Rachel Cox
Publikováno v:
Journal of Psychopharmacology. 33:1610-1619
Background: As exposure to stress has been linked to the onset and maintenance of psychotic illness, its pathogenesis may involve environmental stressors interacting with genetic vulnerability. Aim: To establish whether acute stress interacts with a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::16699ae1143442fdf546a8c12a7b9779
https://doi.org/10.1177/0269881119875465
https://doi.org/10.1177/0269881119875465
Autor:
Rachel Cox, Zuzanna Michalak, Josephine Joel, Alastair Morrison, John L. Waddington, Orna Tighe, Stephen S. Wilson, Steven A. Sheardown, Colm M. P. O’Tuathaigh, Derek J. Blake, Ellen M. Shapland, Brian P. Kirby, Emilie Petit, Alexander D Shaw, David C. Henshall, Konrad Talbot, James N.C. Kew, Niamh Clarke
Publikováno v:
Neuropsychopharmacology. 42:1349-1360
Dysbindin-1, a protein that regulates aspects of early and late brain development, has\ud been implicated in the pathobiology of schizophrenia. As the functional roles of the\ud three major isoforms of dysbindin-1, (A, B and C) remain unknown, we gen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fbee0efa43dacdf44cbaac3d2cfd5b8a
https://doi.org/10.1038/npp.2016.282
https://doi.org/10.1038/npp.2016.282
Autor:
Brian P. Kirby, John L. Waddington, Orna Tighe, Emilie Petit I, Steve Wilson, Lieve Desbonnet, Rachel Cox, Samim Loftus, Colm M. P. O’Tuathaigh, Gerard Clarke, Christina M. Payne, John F. Cryan, Timothy G. Dinan
Publikováno v:
Neuroscience Letters. 736:135218
Dysbindin-1 is implicated in several aspects of schizophrenia, including cognition and both glutamatergic and dopaminergic neurotransmission. Targeted knockout of dysbindin-1A (Dys-1A KO), the most abundant and widely expressed isoform in the brain,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b53a1e2f8eb533c422304fc6b75b9419
https://doi.org/10.1016/j.neulet.2020.135218
https://doi.org/10.1016/j.neulet.2020.135218
Autor:
Rachel Cox, John L. Waddington, Orna Tighe, Colm M. P. O’Tuathaigh, Donna Lai, Richard P. Harvey, Lieve Desbonnet
The complex genetic origins of many human disorders suggest that epistatic (gene × gene) interactions may contribute to a significant proportion of their heritability estimates and phenotypic heterogeneity. Simultaneous disruption of the development
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6f4d65066d3f32db21d96819c0bc97c3
https://eprints.gla.ac.uk/134079/1/134079.pdf
https://eprints.gla.ac.uk/134079/1/134079.pdf
Autor:
John F. Cryan, Gerard Clarke, John L. Waddington, Francesc Perez-Branguli, Donna Lai, Emilie Petit, Marco A. Riva, Claire O'Leary, Samim Loftus, Rachel Cox, Timothy G. Dinan, Richard P. Harvey, Fabio Fumagalli, Lieve Desbonnet, Gerard M. Moloney, Orna Tighe, Kevin J. Mitchell, Colm M. P. O’Tuathaigh
Publikováno v:
Schizophrenia bulletin. 43(1)
Few studies have addressed likely gene × gene (ie, epistatic) interactions in mediating risk for schizophrenia. Using a preclinical genetic approach, we investigated whether simultaneous disruption of the risk factors Neuregulin-1 (NRG1) and Disrupt
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b0c8a2c266841d122c5b0e67a0bc8090
https://pubmed.ncbi.nlm.nih.gov/27613806
https://pubmed.ncbi.nlm.nih.gov/27613806
Autor:
Maria Karayiorgou, Lieve Desbonnet, Orna Tighe, Colm M. P. O’Tuathaigh, John L. Waddington, Joseph A. Gogos
Publikováno v:
Behavioural Brain Research. 228:351-358
Catechol-O-methyltransferase, an enzyme involved in regulating brain catecholamine levels, has been implicated in anxiety, pain and/or stress responsivity. Elements of this putative association remain unclarified, notably whether: (a) COMT variation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::842f42e8456d3b32d75d8e155f8d6b28
https://doi.org/10.1016/j.bbr.2011.12.014
https://doi.org/10.1016/j.bbr.2011.12.014
Autor:
John F. Cryan, Ted Dinan, Emilie Petit, John L. Waddington, Niamh Clarke, Orna Tighe, Lieve Desbonnet, Jeremy Walsh, Colm M. P. O’Tuathaigh, Gerard Clarke, Joseph A. Gogos, Claire O'Leary, Maria Karayiorgou
Publikováno v:
The International Journal of Neuropsychopharmacology; Vol 15
O'Tuathaigh, C M P, Clarke, G, Walsh, J, Desbonnet, L, Petit, E, O'Leary, C, Tighe, O, Clarke, N, Karayiorgou, M, Gogos, J A, Dinan, T G, Cryan, J F & Waddington, J L 2012, ' Genetic vs. pharmacological inactivation of COMT influences cannabinoid-induced expression of schizophrenia-related phenotypes ', International Journal of Neuropsychopharmacology, vol. 15, no. 9, pp. 1331-1342 . https://doi.org/10.1017/S1461145711001581
O'Tuathaigh, C M P, Clarke, G, Walsh, J, Desbonnet, L, Petit, E, O'Leary, C, Tighe, O, Clarke, N, Karayiorgou, M, Gogos, J A, Dinan, T G, Cryan, J F & Waddington, J L 2012, ' Genetic vs. pharmacological inactivation of COMT influences cannabinoid-induced expression of schizophrenia-related phenotypes ', International Journal of Neuropsychopharmacology, vol. 15, no. 9, pp. 1331-1342 . https://doi.org/10.1017/S1461145711001581
Catechol-O-methyltransferase (COMT) is an important enzyme in the metabolism of dopamine and disturbance in dopamine function is proposed to be central to the pathogenesis of schizophrenia. Clinical epidemiological studies have indicated cannabis use
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::52b0de7d85fe02fd6c5de74d9e5b2ff6
Autor:
Ursula Quinn, Orna Tighe, Niamh Clarke, Eoin O'Brien, Patrick Dicker, Alice Stanton, Ciara Vangjeli, Clara Ho
Publikováno v:
Circulation: Cardiovascular Genetics. 3:53-59
Background— Studies of knockout and transgenic mice have demonstrated key roles for genes encoding components of the renin angiotensin system in blood pressure regulation. However, whether polymorphisms in these genes contribute to the cause of ess
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::51fcac08fcfb2a1b0ce2faeacd7e464b
https://doi.org/10.1161/circgenetics.109.899930
https://doi.org/10.1161/circgenetics.109.899930
Autor:
Orna Tighe, Colm M. P. O’Tuathaigh, Donna Lai, Richard P. Harvey, Christoph W. Blau, Andrew J. Fagan, Gavin P. Reynolds, Gerard J. O'Sullivan, John L. Waddington, Michael K. Harte, Christian Kerskens, C. O'Leary
Publikováno v:
European Journal of Neuroscience. 31:349-358
Neuregulin-1 (NRG1) has been shown to play a role in glutamatergic neurotransmission and is a risk gene for schizophrenia, in which there is evidence for hypoglutamatergic function. Sensitivity to the behavioural effects of the psychotomimetic N-meth
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::798ef19d93b7832600501726966b1a16
https://doi.org/10.1111/j.1460-9568.2009.07069.x
https://doi.org/10.1111/j.1460-9568.2009.07069.x