Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Orna Chomsky-Hecht"'
Autor:
Yacob Gomez-Llorente, Fady Jebara, Malay Patra, Radhika Malik, Shahar Nisemblat, Orna Chomsky-Hecht, Avital Parnas, Abdussalam Azem, Joel A. Hirsch, Iban Ubarretxena-Belandia
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
The mHsp60-mHsp10 chaperonin system forms alternating single and double ring complexes to assist protein folding, but the molecular details of this cycle are not fully understood. Here, the authors present cryoEM and crystal structures of key interme
Externí odkaz:
https://doaj.org/article/350b4f4502ee4f4abafe17203699bcde
Autor:
Yehezkel Sasson, Suraj Subramaniam, Tal Buki, Lior Almagor, Orna Chomsky-Hecht, Moshe Katz, Henry Puhl, Stephen R. Ikeda, Nathan Dascal, Joel A. Hirsch
The CaV1 and CaV2 families of voltage-dependent calcium channels play a crucial role in neurotransmitter release, excitation-contraction and many other cellular processes. Comprised of the membrane pore-forming α1, intracellular β and extracellular
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6f4633255754469a601a056dfbea1220
https://doi.org/10.1101/2022.06.21.496996
https://doi.org/10.1101/2022.06.21.496996
Autor:
Moshe, Katz, Suraj, Subramaniam, Orna, Chomsky-Hecht, Vladimir, Tsemakhovich, Veit, Flockerzi, Enno, Klussmann, Joel A, Hirsch, Sharon, Weiss, Nathan, Dascal
Publikováno v:
Proc Natl Acad Sci U S A
L-type voltage-gated Ca(V)1.2 channels crucially regulate cardiac muscle contraction. Activation of β-adrenergic receptors (β-AR) augments contraction via protein kinase A (PKA)–induced increase of calcium influx through Ca(V)1.2 channels. To dat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::cfe1fbaaeaf5c27c5ae0d16b6afd5c00
https://pubmed.ncbi.nlm.nih.gov/34001616
https://pubmed.ncbi.nlm.nih.gov/34001616
Autor:
Veit Flockerzi, Joel A. Hirsch, Moshe Katz, Vladimir Tsemakhovich, Enno Klussmann, Nathan Dascal, Suraj Subramaniam, Sharon Weiss, Orna Chomsky-Hecht
Publikováno v:
Proceedings of the National Academy of Sciences. 118
Significance The strengthening of heart contraction by epinephrine (adrenaline) and norepinephrine starts with the activation of β-adrenergic receptors and culminates in a protein kinase A–mediated increase in Ca 2+ influx through the voltage-gate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fd07fd936cf0ea43eb369f1c79860c90
https://doi.org/10.1073/pnas.2100021118
https://doi.org/10.1073/pnas.2100021118
Autor:
Anouar Belkacemi, Veit Flockerzi, Nathan Dascal, Enno Klussmann, Joel A. Hirsch, Orna Chomsky-Hecht, Vladimir Tsemakhovich, Suraj Subramaniam, Sharon Weiss, Moshe Katz
IntroductionCardiac L-type voltage-gated CaV1.2 channels are crucial in physiological regulation of cardiac excitation-contraction coupling. Adrenergic modulation of CaV1.2 starts with activation of β-adrenergic receptors (AR) and culminates in prot
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::716531c0ead077833279590f7a581ff8
https://doi.org/10.1101/2020.11.30.403964
https://doi.org/10.1101/2020.11.30.403964
Autor:
Joel A. Hirsch, Avital Parnas, Iban Ubarretxena-Belandia, Abdussalam Azem, Orna Chomsky-Hecht, Shahar Nisemblat, Malay Patra, Radhika Malik, Fady Jebara, Yacob Gomez-Llorente
Publikováno v:
Nature Communications
Nature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
'Nature Communications ', vol: 11, pages: 1916-1-1916-14 (2020)
Nature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
'Nature Communications ', vol: 11, pages: 1916-1-1916-14 (2020)
mHsp60-mHsp10 assists the folding of mitochondrial matrix proteins without the negative ATP binding inter-ring cooperativity of GroEL-GroES. Here we report the crystal structure of an ATP (ADP:BeF3-bound) ground-state mimic double-ring mHsp6014-(mHsp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2b81b03e1719e6f6e1c74a1f687f2619
http://europepmc.org/articles/PMC7174398
http://europepmc.org/articles/PMC7174398
Autor:
Doran Hendin-Barak, Adva Benmocha, Nathan Dascal, Joel A. Hirsch, Lior Almagor, Orna Chomsky-Hecht
Publikováno v:
Channels. 6:468-472
Ca(V) channels are multi-subunit protein complexes that enable inward cellular Ca(2+) currents in response to membrane depolarization. We recently described structure-function studies of the intracellular α1 subunit domain I-II linker, directly down
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::352e4d9e87054e4b5f4694aecbf8842d
https://doi.org/10.4161/chan.22078
https://doi.org/10.4161/chan.22078
Autor:
Nathan Dascal, Adva Benmocha, Orna Chomsky-Hecht, Lior Almagor, Joel A. Hirsch, Doran Hendin-Barak
Publikováno v:
The Journal of Neuroscience. 32:7602-7613
Voltage-dependent calcium channels (VDCCs) allow the passage of Ca2+ions through cellular membranes in response to membrane depolarization. The channel pore-forming subunit, α1, and a regulatory subunit (CaVβ) form a high affinity complex where CaV
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3193f00ef6d45d2d6f8d57b6b2accd49
https://doi.org/10.1523/jneurosci.5727-11.2012
https://doi.org/10.1523/jneurosci.5727-11.2012
Autor:
Orna Chomsky-Hecht, Daniel A. Chamovitz, Yair Halimi, Moshe Dessau, Tamir Erez, Joel A. Hirsch
Publikováno v:
The Plant Cell. 20:2815-2834
The COP9 Signalosome (CSN) is a multiprotein complex that was originally identified in Arabidopsis thaliana as a negative regulator of photomorphogenesis and subsequently shown to be a general eukaryotic regulator of developmental signaling. The CSN
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a6abd1878536292ac1525171b07f4052
https://doi.org/10.1105/tpc.107.053801
https://doi.org/10.1105/tpc.107.053801
Publikováno v:
Journal of Biological Chemistry. 278:52323-52332
Voltage-dependent calcium channels selectively enable Ca2+ ion movement through cellular membranes. These multiprotein complexes are involved in a wide spectrum of biological processes such as signal transduction and cellular homeostasis. alpha1 is t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::88cd5c310e0f8f7a1ca24fb8248e68df
https://doi.org/10.1074/jbc.m303564200
https://doi.org/10.1074/jbc.m303564200