Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Orna Atar"'
Autor:
Shiran Hoogi, Tilda Barliya, Raphaëlle Toledano Zur, Orna Atar, Ifat Abramovich, Eyal Gottlieb, Noga Ron-Harel, Cyrille J Cohen
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 12, Iss 7 (2024)
Background T cells play a central role in the antitumor response. However, they often face numerous hurdles in the tumor microenvironment, including the scarcity of available essential metabolites such as glucose and amino acids. Moreover, cancer cel
Externí odkaz:
https://doaj.org/article/16ec3a00ba5d425897d819d2c3231f34
Autor:
Noa Katz, Eitamar Tripto, Naor Granik, Sarah Goldberg, Orna Atar, Zohar Yakhini, Yaron Orenstein, Roee Amit
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
Phage-coat proteins can be used to build synthetic biology parts. Here the authors use an oligo library and machine learning to predict and verify sequences based on binding scores.
Externí odkaz:
https://doaj.org/article/9616667022114a1680b5c585955aa3b8
Autor:
Lior Levy, Leon Anavy, Oz Solomon, Roni Cohen, Michal Brunwasser-Meirom, Shilo Ohayon, Orna Atar, Sarah Goldberg, Zohar Yakhini, Roee Amit
Publikováno v:
Cell Reports, Vol 21, Iss 3, Pp 845-858 (2017)
We use an oligonucleotide library of >10,000 variants to identify an insulation mechanism encoded within a subset of σ54 promoters. Insulation manifests itself as reduced protein expression for a downstream gene that is expressed by transcriptional
Externí odkaz:
https://doaj.org/article/7d4fd9ada4074558bd5319622a2cf784
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-12 (2016)
Some repressors down-regulate gene expression when they bind to a site up to 100 base pairs away from the nearest activator. Here, the authors show that this quenching-like repression can be achieved by the excluded volume effect when a DNA-bound pro
Externí odkaz:
https://doaj.org/article/557097a60f26479c91535bc7e20b92af
Publikováno v:
Nature Biotechnology. 37:1229-1236
The density and long-term stability of DNA make it an appealing storage medium, particularly for long-term data archiving. Existing DNA storage technologies involve the synthesis and sequencing of multiple nominally identical molecules in parallel, r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::81adcc3975bfe1ed5d3561eda6d2252f
https://doi.org/10.1038/s41587-019-0240-x
https://doi.org/10.1038/s41587-019-0240-x
Autor:
Zohar Yakhini, Lisa Kermas, Oz Solomon, Roee Amit, Leon Anavy, Sarah Goldberg, Noa Eden, Orna Atar, Beate Kaufmann, Or Willinger
SummaryNature provides a rich toolbox of dynamic nucleic acid structures that are widespread in cells and affect multiple biological processes1. Recently, non-canonical structures gained renewed scientific and biotechnological interest2,3. One partic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::75f2d26d9539fe59f09da61faf312fce
Autor:
Roee Amit, Sarah Goldberg, Noa Katz, Yaron Orenstein, Orna Atar, Zohar Yakhini, Eitamar Tripto
The design-build-test (DBT) cycle in synthetic biology is considered to be a major bottleneck for progress in the field. The emergence of high-throughput experimental techniques, such as oligo libraries (OLs), combined with machine learning (ML) algo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::466234718066bc61f9c9680128e9ddc2
Publikováno v:
Journal of Visualized Experiments.
In the initiation step of protein translation, the ribosome binds to the initiation region of the mRNA. Translation initiation can be blocked by binding of an RNA binding protein (RBP) to the initiation region of the mRNA, which interferes with ribos
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6b113215a4c09607319710e5995a6314
https://doi.org/10.3791/59611
https://doi.org/10.3791/59611
Autor:
Roee Amit, Noa Katz, Beate Kaufmann, Orna Atar, Sarah Goldberg, Roni Cohen, Zohar Yakhini, Oz Solomon
Publikováno v:
ACS synthetic biology. 7(12)
We study translation repression in bacteria by engineering a regulatory circuit that functions as a binding assay for RNA binding proteins (RBP) in vivo. We do so by inducing expression of a fluorescent protein-RBP chimera, together with encoding its
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::522b9b7ae0130eb8b3d18bf44a59c4ab
https://pubmed.ncbi.nlm.nih.gov/30408420
https://pubmed.ncbi.nlm.nih.gov/30408420
Autor:
Roee Amit, Oz Solomon, Noa Katz, Sarah Goldberg, Orna Atar, Beate Kaufmann, Zohar Yakhini, Roni Cohen
Publikováno v:
Cell systems. 9(1)
Summary The construction of complex gene-regulatory networks requires both inhibitory and upregulatory modules. However, the vast majority of RNA-based regulatory “parts” are inhibitory. Using a synthetic biology approach combined with SHAPE-seq,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::97ffbb1cc314e3509d0aaa1a66cdd7ec
https://pubmed.ncbi.nlm.nih.gov/31129060
https://pubmed.ncbi.nlm.nih.gov/31129060