Zobrazeno 1 - 10
of 90
pro vyhledávání: '"Ormaplatin"'
Publikováno v:
Dalton Transactions. 47:5548-5552
Ormaplatin ([Pt(dach)Cl4]) represents one of the three primary structural prototypes of Pt(iv) anticancer-active prodrugs. The reduction of ormaplatin by an extended series of thiols has been studied kinetically in a broad pH range. A novel and remar
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8aec1c9431911607132037293bb99e62
https://doi.org/10.1039/c8dt00852c
https://doi.org/10.1039/c8dt00852c
Publikováno v:
Transition Metal Chemistry. 41:295-304
N-acetyl-l-cysteine (NAC) is an antioxidant and a supplement and has been demonstrated to have protective effects for a variety of toxic effects of heavy metals. Although previous works have shown that NAC can ameliorate the severe toxic effects of c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b861b4b4949110dfeb2c473b1b640c21
https://doi.org/10.1007/s11243-016-0021-z
https://doi.org/10.1007/s11243-016-0021-z
Publikováno v:
Dalton Transactions. 45:11326-11337
The reductions of Pt(iv) anticancer prodrugs [Pt(dach)Cl4] (ormaplatin/tetraplatin), cis-[Pt(NH3)2Cl4], and cis,cis,trans-[Pt(NH3)2Cl2Br2] by the several dominant reductants in human plasma have been characterized kinetically in this work, including
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2d418cbaf6accc956e3bdc6fe922a024
https://doi.org/10.1039/c6dt01804a
https://doi.org/10.1039/c6dt01804a
Publikováno v:
Transition Metal Chemistry. 40:347-353
Ormaplatin ([Pt(dach)Cl4]) is a prototypical of Pt(IV) anticancer prodrug; its reduction by 3,6-dioxa-1,8-octanedithiol (DODT, a model compound for the active site of thioredoxin), has been characterized at 25.0 °C and in a wide pH range by rapid sc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5cdb012b874ac02db2411ed15bf1d0fe
https://doi.org/10.1007/s11243-015-9923-4
https://doi.org/10.1007/s11243-015-9923-4
Akademický článek
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Publikováno v:
Transition Metal Chemistry. 39:127-133
Sodium thiosulfate has been utilized as a rescuing agent for relief of the toxic effects of cisplatin and carboplatin. In this work, we characterized the kinetics of reactions of the trans-dichloro-platinum(IV) complexes cis-[Pt(NH3)2Cl4], ormaplatin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a37f90fab24e696911c73a3b3fd7a943
https://doi.org/10.1007/s11243-013-9781-x
https://doi.org/10.1007/s11243-013-9781-x
Publikováno v:
Bioorganicmedicinal chemistry letters. 26(17)
The reduction of ormaplatin (tetraplatin), a prototype for Pt(IV) anticancer prodrugs, by glutathione (GSH) was kinetically characterized over a wide pH range at 25.0 °C and 1.0 M ionic strength. The reduction follows overall second-order kinetics,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::be10b54d0a3e3f53f53c2907b38158c1
https://pubmed.ncbi.nlm.nih.gov/27481559
https://pubmed.ncbi.nlm.nih.gov/27481559
Autor:
Walter J. Loos, Erik A.C. Wiemer, Anton W. M. Boersma, Jozien Helleman, Herman Burger, Els M.J.J. Berns, Ron H.J. Mathijssen, Adja Zoumaro-Djayoon
Publikováno v:
British Journal of Pharmacology. 159:898-908
BACKGROUND: Solute carriers (SLCs), in particular organic cation transporters (OCTs), have been implicated in the cellular uptake of platinum-containing anticancer compounds. The activity of these carriers may determine the pharmacokinetics and the s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::eef623ac348154247cd77cbb44155e3b
https://doi.org/10.1111/j.1476-5381.2009.00569.x
https://doi.org/10.1111/j.1476-5381.2009.00569.x
Autor:
Michael I. Koukourakis
Publikováno v:
Seminars in Oncology. 30:18-30
A large body of experimental evidence suggests that amifostine (Ethyol, WR-2721; MedImmune, Inc, Gaithersburg, MD) is a selective cytoprotector of normal tissues. Nevertheless, several experimental studies, most of which were conducted in the early 1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cf71faa796f6bbfa3a4c7bfb327c8dda
https://doi.org/10.1053/j.seminoncol.2003.11.014
https://doi.org/10.1053/j.seminoncol.2003.11.014
Publikováno v:
British Journal of Cancer
Platinum-based drugs are very useful in cancer therapy but are associated with neurotoxicity in the clinic. To investigate the mechanism of neurotoxicity, dorsal root ganglia of rats treated with various platinum drugs were studied. Cell body, nuclea
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0b63a3c138fc2bf2efe9c114e3623233
http://europepmc.org/articles/PMC2375155
http://europepmc.org/articles/PMC2375155