Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Orly Perl"'
Autor:
Noah Joseph, Shlomi Jakubowicz, Orly Perl, Mira Barda-Saad, Maor H. Pauker, Inbal Wortzel, Barak Reicher, Elad Noy
Publikováno v:
Journal of Biological Chemistry. 289:34503-34519
T cell antigen receptor (TCR) engagement has been shown to activate pathways leading to actin cytoskeletal polymerization and reorganization, which are essential for lymphocyte activation and function. Several actin regulatory proteins were implicate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b2a420f2e881f19a6da6eda436bb6573
https://doi.org/10.1074/jbc.m114.591685
https://doi.org/10.1074/jbc.m114.591685
Publikováno v:
Molecular and Cellular Biology. 32:3153-3163
The Wiskott-Aldrich syndrome protein (WASp) is a key regulator of actin dynamics during cell motility and adhesion, and mutations in its gene are responsible for Wiskott-Aldrich syndrome (WAS). Here, we demonstrate that WASp is ubiquitylated followin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::19dfc6d0c4d9a332943636f71a07c537
https://doi.org/10.1128/mcb.00161-12
https://doi.org/10.1128/mcb.00161-12
Publikováno v:
Molecular and Cellular Biology. 31:2653-2666
T cell antigen receptor (TCR) activation triggers profound changes in the actin cytoskeleton. In addition to controlling cellular shape and polarity, this process regulates vital T cell responses, such as T cell adhesion, motility, and proliferation.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::73a401b54a5de509eed49cecaef3716f
https://doi.org/10.1128/mcb.01358-10
https://doi.org/10.1128/mcb.01358-10
Autor:
Mira Barda-Saad, Ettore Appella, Orly Perl, Nirit Hassan, Andrea Balbo, Peter Schuck, Hiroshi Yamaguchi, Jon C. D. Houtman, Maor H. Pauker, Naoto Shirasu, Lawrence E. Samelson
Publikováno v:
The EMBO Journal. 29:2315-2328
T-cell antigen receptor (TCR) engagement induces formation of multi-protein signalling complexes essential for regulating T-cell functions. Generation of a complex of SLP-76, Nck and VAV1 is crucial for regulation of the actin machinery. We define th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0e0b986d061804cbf95ce2c336989a72
https://doi.org/10.1038/emboj.2010.133
https://doi.org/10.1038/emboj.2010.133
Autor:
Rachel Zamostiano, Merav Bassan, Orly Perl, Gretchen Gibney, Albert Pinhasov, Douglas E. Brenneman, Ariane Davidson, Haim Bassan, Cila Blat, Eliezer Giladi, Illana Gozes, Gordon W. Glazner
Publikováno v:
Journal of Neurochemistry. 72:1283-1293
The vulnerability of neurons and the irreversibility of loss make discoveries of neuroprotective compounds fundamentally important. Here, the complete coding sequence of a novel protein (828 amino acids, pl 5.99), derived from mouse neuroglial cells,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::687b7446a7773faadc6b011b49bac3a7
https://doi.org/10.1046/j.1471-4159.1999.0721283.x
https://doi.org/10.1046/j.1471-4159.1999.0721283.x
Publikováno v:
The FASEB Journal. 17:1-15
Recent studies have suggested that the alpha7 nicotinic acetylcholine receptor (alpha7 AChR) may play a role in the pathogenesis of schizophrenia. In search for peripheral biological markers for schizophrenia we have investigated alpha7 mRNA levels i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fb2ed2e825413fefca8e09351fdc86c7
https://doi.org/10.1096/fj.03-0104fje
https://doi.org/10.1096/fj.03-0104fje
Autor:
Albert Pinhasov, Ruth A. Steingart, Orly Perl, Douglas E. Brenneman, Illana Gozes, Rachel Zamostiano, Roy Atlas, Merav Bassan
Publikováno v:
Neuroscience Letters. 264:9-12
Activity-dependent neurotrophic factor (ADNF) was recently isolated from conditioned media of astrocytes stimulated with vasoactive intestinal peptide (VIP). ADNF provided neuroprotection at femtomolar concentration against a wide variety of toxic in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d72573a1849d60d0237278b22ce8bfd0
https://doi.org/10.1016/s0304-3940(99)00168-8
https://doi.org/10.1016/s0304-3940(99)00168-8
Autor:
S. Rubinraut, Orly Perl, Mati Fridkin, Illana Gozes, Eliezer Giladi, Ariane Davidson, Osnat Ashur-Fabian
Publikováno v:
Proceedings of the National Academy of Sciences. 96:4143-4148
The understanding of the molecular mechanisms leading to peptide action entails the identification of a core active site. The major 28-aa neuropeptide, vasoactive intestinal peptide (VIP), provides neuroprotection. A lipophilic derivative with a stea
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b40ac8bef7f48a5145ed8531512dc85b
https://doi.org/10.1073/pnas.96.7.4143
https://doi.org/10.1073/pnas.96.7.4143
Autor:
Ester Rosenthal, Tsvee Lapidot, Shoham Shivtiel, Karin Golan, Orit Kollet, Abraham Avigdor, Polina Goichberg, David Naor, Arnon Nagler, Isabelle Petit, Alexander Kalinkovich, Ayelet Dar, Igor B. Resnick, Orly Perl, Melania Tesio, Yaron Vagima, Yechiel N. Gellman, Izhar Hardan
The mechanisms governing hematopoietic progenitor cell mobilization are not fully understood. We report higher membrane type 1–MMP (MT1-MMP) and lower expression of the MT1-MMP inhibitor, reversion-inducing cysteine-rich protein with Kazal motifs (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aee41f6c518937607c989686a258a60d
https://europepmc.org/articles/PMC2648678/
https://europepmc.org/articles/PMC2648678/
Publikováno v:
Neuropsychobiology. 53(2)
Background: There is evidence that the nicotinic α7-acetylcholine receptor (α7-AChR) is involved in the pathophysiology of schizophrenia. Several neurotransmitter receptors, including α7-AChR, have been demonstrated on peripheral blood lymphocytes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::914d4b939328a0863a1bae7f1e9d66d2
https://pubmed.ncbi.nlm.nih.gov/16511340
https://pubmed.ncbi.nlm.nih.gov/16511340