Zobrazeno 1 - 10
of 80
pro vyhledávání: '"Orly Lazarov"'
Hippocampal functional connectivity across age in an App knock-in mouse model of Alzheimer's disease
Autor:
Zachery D. Morrissey, Jin Gao, Liang Zhan, Weiguo Li, Igor Fortel, Takaomi Saido, Takashi Saito, Arnold Bakker, Scott Mackin, Olusola Ajilore, Orly Lazarov, Alex D. Leow
Publikováno v:
Frontiers in Aging Neuroscience, Vol 14 (2023)
IntroductionAlzheimer's disease (AD) is a progressive neurodegenerative disease. The early processes of AD, however, are not fully understood and likely begin years before symptoms manifest. Importantly, disruption of the default mode network, includ
Externí odkaz:
https://doaj.org/article/d4916852bbf34e2c814ef4504e78801f
Autor:
Matthew K. Tobin, Terilyn K. L. Stephen, Kyra L. Lopez, Melissa R. Pergande, Amelia M. Bartholomew, Stephanie M. Cologna, Orly Lazarov
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 9, Iss 7 (2020)
Background Brain repair mechanisms fail to promote recovery after stroke, and approaches to induce brain regeneration are scarce. Mesenchymal stem cells (MSC) are thought to be a promising therapeutic option. However, their efficacy is not fully eluc
Externí odkaz:
https://doaj.org/article/147d76f157644505a0ac5ac13c1fe57c
Autor:
Carolyn Hollands, Matthew Kyle Tobin, Michael Hsu, Kianna Musaraca, Tzong-Shiue Yu, Rachana Mishra, Steven G. Kernie, Orly Lazarov
Publikováno v:
Molecular Neurodegeneration, Vol 12, Iss 1, Pp 1-13 (2017)
Abstract Background The molecular mechanism underlying progressive memory loss in Alzheimer’s disease is poorly understood. Neurogenesis in the adult hippocampus is a dynamic process that continuously changes the dentate gyrus and is important for
Externí odkaz:
https://doaj.org/article/cc2c7994e23942e5bc539005e29c6d86
Autor:
Jacqueline A Bonds, Yafit Kuttner-Hirshler, Nancy Bartolotti, Matthew K Tobin, Michael Pizzi, Robert Marr, Orly Lazarov
Publikováno v:
PLoS ONE, Vol 10, Iss 6, p e0131266 (2015)
Presenilin-1 (PS1), the catalytic core of the aspartyl protease γ-secretase, regulates adult neurogenesis. However, it is not clear whether the role of neurogenesis in hippocampal learning and memory is PS1-dependent, or whether PS1 loss of function
Externí odkaz:
https://doaj.org/article/85c0767ceb2e4703803a42b489afeda1
Publikováno v:
PLoS ONE, Vol 8, Iss 5, p e64460 (2013)
Experience of mice in a complex environment enhances neurogenesis and synaptic plasticity in the hippocampus of wild type and transgenic mice harboring familial Alzheimer's disease (FAD)-linked APPswe/PS1ΔE9. In FAD mice, this experience also reduce
Externí odkaz:
https://doaj.org/article/9592890a532445e09a1928ca247b1398
Autor:
Evgenia Salta, Orly Lazarov, Carlos P. Fitzsimons, Rudolph Tanzi, Paul J. Lucassen, Se Hoon Choi
Publikováno v:
Cell Stem Cell, 30(2), 120-136. Cell Press
Adult hippocampal neurogenesis (AHN) drops sharply during early stages of Alzheimer's disease (AD), via unknown mechanisms, and correlates with cognitive status in AD patients. Understanding AHN regulation in AD could provide a framework for innovati
Autor:
Aashutosh U Shetti, Abhirami Ramakrishnan, Liudmila Romanova, Wenping Li, Khanh Vo, Ipsita Volety, Ishara Ratnayake, Terilyn Stephen, Richard D Minshall, Stephanie M Cologna, Orly Lazarov
Publikováno v:
Brain.
Patients with type 2 diabetes exhibit severe impairments in insulin signalling in the brain and are five times more likely to develop Alzheimer’s disease. However, what leads to these impairments is not fully understood. Here, we show reduced expre
Autor:
Rachana Mishra, Trongha Phan, Pavan Kumar, Zachery Morrissey, Muskan Gupta, Carolyn Hollands, Aashutosh Shetti, Kyra Lauren Lopez, Mark Maienschein-Cline, Hoonkyo Suh, Rene Hen, Orly Lazarov
Publikováno v:
Journal of Experimental Medicine. 219
Hippocampal neurogenesis is impaired in Alzheimer’s disease (AD) patients and familial Alzheimer’s disease (FAD) mouse models. However, it is unknown whether new neurons play a causative role in memory deficits. Here, we show that immature neuron
Autor:
Terilyn K. L. Stephen, Trongha Phan, Ahmed Disouky, Pavan Kumar, Rachana Mishra, Muskan Gupta, Orly Lazarov, Karen Rakowiecki
Publikováno v:
Stem Cell Reports
Autor:
Ahmed Disouky, Matthew K. Tobin, William G. Honer, Namhee Kim, Robert J. Dawe, David A. Bennett, Konstantinos Arfanakis, Orly Lazarov
Publikováno v:
Biological Psychiatry. 91:S16