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Supplementary Table 1 from Combination of Imatinib with CXCR4 Antagonist BKT140 Overcomes the Protective Effect of Stroma and Targets CML In Vitro and In Vivo

Autor: Arnon Nagler, Amnon Peled, Orly Eizenberg, Eithan Galun, Ori Wald, Hanna Wald, Michal Abraham, Maya Koren-Michowitz, Orly Blaier, Merav Darash-Yahana, Katia Beider

PDF - 43K, Primer sequences.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c9a61baa295f7c97e146cfac6d3f6657
https://doi.org/10.1158/1535-7163.22499821.v1

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Supplementary Figure 2 from Combination of Imatinib with CXCR4 Antagonist BKT140 Overcomes the Protective Effect of Stroma and Targets CML In Vitro and In Vivo

Autor: Arnon Nagler, Amnon Peled, Orly Eizenberg, Eithan Galun, Ori Wald, Hanna Wald, Michal Abraham, Maya Koren-Michowitz, Orly Blaier, Merav Darash-Yahana, Katia Beider

PDF - 32K, BKT140 structure.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b96d67a9d94b965b9f80d23b3bda3b48
https://doi.org/10.1158/1535-7163.22499824

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Data from Combination of Imatinib with CXCR4 Antagonist BKT140 Overcomes the Protective Effect of Stroma and Targets CML In Vitro and In Vivo

Autor: Arnon Nagler, Amnon Peled, Orly Eizenberg, Eithan Galun, Ori Wald, Hanna Wald, Michal Abraham, Maya Koren-Michowitz, Orly Blaier, Merav Darash-Yahana, Katia Beider

Functional role of CXCR4 in chronic myelogenous leukemia (CML) progression was evaluated. Elevated CXCR4 significantly increased the in vitro survival and proliferation in response to CXCL12. CXCR4 stimulation resulted in activation of extracellular

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::9edca01f214dba541b8cf90406fcb3fd
https://doi.org/10.1158/1535-7163.c.6536275

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Supplementary Figure 1 from Combination of Imatinib with CXCR4 Antagonist BKT140 Overcomes the Protective Effect of Stroma and Targets CML In Vitro and In Vivo

Autor: Arnon Nagler, Amnon Peled, Orly Eizenberg, Eithan Galun, Ori Wald, Hanna Wald, Michal Abraham, Maya Koren-Michowitz, Orly Blaier, Merav Darash-Yahana, Katia Beider

PDF - 90K, Demonstrates CXCR4 expression and function in K562 and K562LG-CXCR4 cells.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0e7b4c12a2bde7ab78480e0e3a73ee11
https://doi.org/10.1158/1535-7163.22499827.v1

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Combination of imatinib with CXCR4 antagonist BKT140 overcomes the protective effect of stroma and targets CML in vitro and in vivo

Autor: Amnon Peled, Merav Darash-Yahana, Orly Eizenberg, Orly Blaier, Arnon Nagler, Ori Wald, Eithan Galun, Maya Koren-Michowitz, Hanna Wald, Michal Abraham, Katia Beider

Publikováno v: Molecular cancer therapeutics. 13(5)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::307535b0ec5918e52163b477ddeb91a5
https://pubmed.ncbi.nlm.nih.gov/24502926

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Combination of Imatinib with CXCR4 Antagonist BKT140 Overcomes the Protective Effect of Stroma and Targets CML in Vitro and in Vivo

Autor: Boaz Pal, Maya Koren-Michowitz, Hanna Wald, Michal Abraham, Orly Eizenberg, Amnon Peled, Orly Blaier, Katia Beider, Merav Darash-Yahana, Arnon Nagler

Publikováno v: Blood. 120:3735-3735

Abstract 3735 Background: Chronic myeloid leukemia (CML) is myeloproliferative disease of hematopoietic stem cells that is driven by the constitutively active oncogenic tyrosine kinase BCR-ABL. Inhibition of BCR-ABL activity by tyrosine kinase inhibi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::393abb6f21f07bfab5fc0882b70fff72
https://doi.org/10.1182/blood.v120.21.3735.3735

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