Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Orlando Pando"'
Publikováno v:
Nachrichten aus der Chemie. 58:526-532
N-alkylierte Peptide wie die Dolastatine und vor allem die jungeren Tubulysine gelten als vielversprechende Leitsubstanzen fur die Krebstherapie. Konjugate der Tubulysine vereinen Tumorselektivitat und Aktivitat in bisher nicht bekanntem Mas.
Publikováno v:
Tetrahedron. 62:8327-8334
A general approach towards the preparation of peptide–steroid conjugates has been addressed. Utilizing the Ugi reaction, five peptidomimetic-steroid hybrids were achieved in good to excellent yields from carboxy- and amino-spirostanes and mono-prot
Autor:
Odette Concepción, Carlos Pérez, Francisco Coll, Orlando Pando, Daniel G. Rivera, Vivian Leliebre-Lara
Publikováno v:
Letters in Organic Chemistry. 3:519-522
Autor:
Rainer Preusentanz, Ludger A. Wessjohann, Wolfgang Richter, Simon Dörner, Annika Denkert, Orlando Pando, Andrea Porzel
Publikováno v:
Organic Letters. 11:5567-5569
The first total synthesis of tubulysin B is described. The aziridine route to tubuphenylalanine (Tup) of the tubulysin D/U-series could not be transferred to the synthesis of tubutyrosine (blue moiety). Therefore, tubutyrosine (Tut) was synthesized b
Autor:
Rainer Preusentanz, Sebastian Stark, Annika Denkert, Ludger A. Wessjohann, Andrea Porzel, Orlando Pando
Publikováno v:
Journal of the American Chemical Society. 133(20)
The synthesis of a new generation of highly cytotoxic tubulysin analogues (i.e., tubugis) is described. In the key step, the rare, unstable, and synthetically difficult to introduce tertiary amide–N,O-acetal moiety required for high potency in natu
Autor:
Orlando Pando, Ludger A. Wessjohann, Simon Doerner, Annika Denkert, Rainer Preusentanz, Wolfgang Richter, Andrea Porzel
Publikováno v:
ChemInform. 41
Publikováno v:
The Journal of organic chemistry. 73(16)
Bile acids are important scaffolds in medicinal and supramolecular chemistry. However, the use of seco bile acids, i.e., bile acids with opened rings, as cores or building blocks for the assembly of complex peptide conjugates or macrocycles has remai
Publikováno v:
Steroids. 72(5)
A detailed study of the Baeyer-Villiger reaction of 3-ketosteroids has been performed by using m -chloroperoxybenzoic and trifluoroperoxyacetic acids as oxidants. The process was fully regiospecific for 3-keto-5α-steroids with the employ of both per
Autor:
Fredy León, Vivian Leliebre-Lara, Daniel G. Rivera, Orlando Pando, Francisco Coll, Deysma Coll
Publikováno v:
ChemInform. 35
Homogeneous non-aqueous permanganate dihydroxylation is used to synthesize spirostanic analogues of brassinosteroids bearing a variety of oxygen functions on ring B.
Autor:
Francisco Coll, Orlando Pando, Daniel G. Rivera, Vivian Leliebre-Lara, Deysma Coll, Fredy León
Publikováno v:
Journal of Chemical Research. 2004:53-54
Homogeneous non-aqueous permanganate dihydroxylation is used to synthesize spirostanic analogues of brassinosteroids bearing a variety of oxygen functions on ring B.