Zobrazeno 1 - 10
of 124
pro vyhledávání: '"Orlando Laitano"'
Autor:
Franccesco P. Boeno, PhD, Luiz Fernando W. Roesch, PhD, Philip A. Efron, MD, Orlando Laitano, PhD
Publikováno v:
Critical Care Explorations, Vol 6, Iss 8, p e1144 (2024)
CONTEXT:. Sepsis leads to multiple organ dysfunction and negatively impacts patient outcomes. Skeletal muscle disuse is a significant comorbidity in septic patients during their ICU stay due to prolonged immobilization. HYPOTHESIS:. Combination of se
Externí odkaz:
https://doaj.org/article/57135bb2f5cb4c758971ab7e49f3a7f7
Autor:
Daria Neyroud, Orlando Laitano, Aneesha Dasgupta, Christopher Lopez, Rebecca E. Schmitt, Jessica Z. Schneider, David W. Hammers, H. Lee Sweeney, Glenn A. Walter, Jason Doles, Sarah M. Judge, Andrew R. Judge
Publikováno v:
Communications Biology, Vol 6, Iss 1, Pp 1-17 (2023)
Abstract Cancer-induced muscle wasting reduces quality of life, complicates or precludes cancer treatments, and predicts early mortality. Herein, we investigate the requirement of the muscle-specific E3 ubiquitin ligase, MuRF1, for muscle wasting ind
Externí odkaz:
https://doaj.org/article/325bfe808b054fee84c0ec177166dbea
Publikováno v:
BMJ Medicine, Vol 1, Iss 1 (2022)
Exertional heat stroke, the third leading cause of mortality in athletes during physical activity, is the most severe manifestation of exertional heat illnesses. Exertional heat stroke is characterised by central nervous system dysfunction in people
Externí odkaz:
https://doaj.org/article/aa2fb6540ed841db86b619684fbd3a33
Autor:
Orlando Laitano, Gerard P. Robinson, Kevin O. Murray, Christian K. Garcia, Alex J. Mattingly, Deborah Morse, Michelle A. King, John D. Iwaniec, Jamal M. Alzahrani, Thomas L. Clanton
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
Abstract Skeletal muscles secrete a wide variety of immunologically active cytokines, but the functional significance of this response to in vivo innate immunity is not understood. We addressed this by knocking out the toll receptor adapter protein,
Externí odkaz:
https://doaj.org/article/00a910c9bab542beb23621aebc00bfec
Autor:
Orlando Laitano, Jose Pindado, Isela Valera, Ray A. Spradlin, Kevin O. Murray, Katelyn R. Villani, Jamal M. Alzahrani, Terence E. Ryan, Philip A. Efron, Leonardo F. Ferreira, Elisabeth R. Barton, Thomas L. Clanton
Publikováno v:
Physiological Reports, Vol 9, Iss 14, Pp n/a-n/a (2021)
Abstract Sepsis induces a myopathy characterized by loss of muscle mass and weakness. Septic patients undergo prolonged periods of limb muscle disuse due to bed rest. The contribution of limb muscle disuse to the myopathy phenotype remains poorly des
Externí odkaz:
https://doaj.org/article/358f8f58bff24df79d0a3e6ac1268257
Autor:
Denise de Melo-Marins, Juliano Boufleur Farinha, Franccesco Pinto Boeno, Alexandra Ferreira Vieira, Samuel Vargas Munhoz, Gabriela Cristina dos Santos, Mauricio Krause, Orlando Laitano, Alvaro Reischak-Oliveira
Publikováno v:
Life, Vol 11, Iss 11, p 1144 (2021)
Background: Reduced glutathione (GSH) is one of the main thiols involved in antioxidant defense. Changes in circulatory levels of GSH during exercise are associated with hyperthermia and dehydration. The mechanisms by which these alterations occur ar
Externí odkaz:
https://doaj.org/article/cb05339ad8d44c59b4b2851cf00a6983
Autor:
José Fernando Vila Nova de Moraes, Orlando Laitano, Marcelo Magalhães Sales, Ricardo Yukio Asano, Vinícius Carolino de Souza, Otávio de Toledo Nóbrega, Carmen Sílvia Grubert Campbell
Publikováno v:
Revista Brasileira de Cineantropometria e Desempenho Humano, Vol 18, Iss 3, Pp 259-267 (2016)
Obesity is considered a disease with multiple etiologies. Recent advances in technology have pointed candidate genes that are related to weight gain in several populations. However, in countries with ethnic miscegenation, such as Brazil, studies of t
Externí odkaz:
https://doaj.org/article/0990c1e71f5d4708b612521b64eeee3d
Autor:
Orlando Laitano, Laila H. Sheikh, Alex J. Mattingly, Kevin O. Murray, Leonardo F. Ferreira, Thomas L. Clanton
Publikováno v:
Frontiers in Physiology, Vol 9 (2018)
Hyperthermia and dehydration can occur during exercise in hot environments. Nevertheless, whether elevations in extracellular osmolality contributes to the increased skeletal muscle tension, sarcolemmal injury, and oxidative stress reported in warm c
Externí odkaz:
https://doaj.org/article/4b0181e89af54437832148cea7f6e345
Autor:
Denise de Melo-Marins, Ana Angélica Souza-Silva, Gabriel Lucas Leite da Silva-Santos, Francisco de Assis Freire-Júnior, Jason Kai Wei Lee, Orlando Laitano
Publikováno v:
Frontiers in Nutrition, Vol 5 (2018)
The optimal hydration plan [i.e., drink to thirst, ad libitum (ADL), or personalized plan] to be adopted during exercise in recreational athletes has recently been a matter of debate and, due to conflicting results, consensus does not exist. In the p
Externí odkaz:
https://doaj.org/article/8aa13cdb0990459dbc1f3dec2340b694
Publikováno v:
Physiological Reports, Vol 5, Iss 23, Pp n/a-n/a (2017)
Abstract Catecholamines stimulate interleukin‐6 (IL‐6) secretion in skeletal muscles. However, whether other cytokines are secreted is currently unknown. Skeletal muscle ex vivo preparations commonly used to study cytokine secretion have dealt wi
Externí odkaz:
https://doaj.org/article/eb90f326727d41b397b8f99ea66d60c9