Zobrazeno 1 - 10
of 50
pro vyhledávání: '"Orlando Ghirardi"'
Autor:
Luca Pescatori, Orlando Ghirardi, Roberto Di Santo, Diana Celona, Giovanna Guiso, Federica Rosi, Fabrizio Giorgi, Roberta Costi, Mario Vertechy, Patrizia Minetti, Paola Piovesan, Luigi Scipione, Mauro Marzi, Giuliana Cuzzucoli Crucitti, Silvio Caccia
Publikováno v:
Journal of Medicinal Chemistry
Journal of Medicinal Chemistry, American Chemical Society, 2012, 55 (19), pp.8538-48. ⟨10.1021/jm301105m⟩
Journal of Medicinal Chemistry, American Chemical Society, 2012, 55 (19), pp.8538-48. ⟨10.1021/jm301105m⟩
International audience; Dyes like CR are able to inhibit the aggregation of Aβ fibrils. Thus, a screening of a series of dyes including ABBB (1) was performed. Its main component 2 tested in an in vitro assay (i.e., ThT assay) showed good potency at
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6070b3b53fd6a813e85dee66b31b890d
https://doi.org/10.1021/jm301105m
https://doi.org/10.1021/jm301105m
Publikováno v:
Archives of Virology. 154:1539-1544
On the basis of the structural homologies between ST1859 (1[(2-hydroxy-1-naphtyl)methyl]-2-naphthol) and the anti-prion agents and its anti-amyloidogenic activity, we tested whether this molecule altered the biochemical properties of aggregates forme
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c212eea5d0a7679d82f8f4e0d8fd7840
https://doi.org/10.1007/s00705-009-0471-0
https://doi.org/10.1007/s00705-009-0471-0
Autor:
Antonio Verdoliva, Maurizio Colombo, Franco Borsini, Maria Rossi, Luca Battistini, Debora Capobianco, Maria Teresa Cencioni, Domenico Mastroianni, Orlando Ghirardi, Valentina Bombardi, Paola Piovesan
Publikováno v:
Molecular Immunology. 46:2524-2532
The most promising approach in Alzheimer disease immunotherapy is represented by amyloid beta derivatives with low intrinsic neurotoxicity and minimal overall T cell responses. To avoid toxicity and autoimmune response, we have designed a new class o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b5f0b5ce18be06e40a010bf58f51e570
https://doi.org/10.1016/j.molimm.2009.05.017
https://doi.org/10.1016/j.molimm.2009.05.017
Autor:
Elisa Ognibene, Giovanni Laviola, Antonio Caprioli, Luigi Aloe, Syed F. Ali, Walter Adriani, Orlando Ghirardi
Publikováno v:
Progress in Neuro-Psychopharmacology and Biological Psychiatry. 32:1269-1276
Objective and methods The reeler heterozygous (HZ) mice have provided a model for studying the relationship between reelin (a protein of extracellular matrix) haploinsufficiency and the emergence of neuropsychiatric diseases. In a neurodevelopmental
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f474e7bcc4ec070c5e04cc06a1297ca7
https://doi.org/10.1016/j.pnpbp.2008.03.023
https://doi.org/10.1016/j.pnpbp.2008.03.023
Autor:
Roberto Coccurello, Antonio Caprioli, Anna Moles, Franco Borsini, Roberto Conti, Paolo Carminati, Orlando Ghirardi
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 326:905-911
A mouse model of atypical antipsychotic-associated adverse effects was used to compare the liability to induce weight gain, food intake, and metabolic alterations after chronic olanzapine (OL; LY170053, 2-methyl-4-(4-methyl-1-piperazinyl)-10H-thieno-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ebdaa1eecef2fc78af47ed0b468dd9dd
https://doi.org/10.1124/jpet.108.137240
https://doi.org/10.1124/jpet.108.137240
Publikováno v:
Annals of the New York Academy of Sciences. 1122:260-275
This study deals with the possible inhibitory role played by acetyl-l-carnitine (ALC) against methamphetamine (METH)-induced behavioral sensitization. Because valproate (VAL) inhibits the behavioral sensitization exerted by different psychostimulants
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2ecf6cad87660fc93d9912ade3a757e7
https://doi.org/10.1196/annals.1403.019
https://doi.org/10.1196/annals.1403.019
Autor:
Orlando Ghirardi, Antonio Caprioli, Emilie Heuland, Giovanni Laviola, Walter Adriani, Elisa Ognibene
Publikováno v:
Behavioural Pharmacology. 17:525-533
Among transgenic mouse models of Alzheimer's disease, APP-SWE mice have been shown to develop beta-amyloid plaques and to exhibit progressive impairment of cognitive function. Human Alzheimer's disease, however, also includes secondary clinical manif
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::48433d7ffa7a3d0b18f5539c4f9b75e1
https://doi.org/10.1097/00008877-200609000-00019
https://doi.org/10.1097/00008877-200609000-00019
Publikováno v:
Genes, Brain and Behavior. 5:249-256
The possibility of detecting progressive changes in cognitive function reflecting the spatio-temporal pattern of beta-amyloid peptide (Abeta) deposition was investigated in Tg2576 mice overexpressing the human mutant amyloid precursor protein (hAPP).
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::502de27514eb6944e557ad4c5bf17710
https://doi.org/10.1111/j.1601-183x.2005.00160.x
https://doi.org/10.1111/j.1601-183x.2005.00160.x
Publikováno v:
Experimental Gerontology. 31:577-587
The natural variability of behavioral performance of aged rats was used to evaluate the effect of acetyl- l -camitine (ALCAR) on spatial learning and NGF levels in different brain areas. We used a cluster analysis procedure to subdivide the aged anim
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::80fc63fb02dbbf9f6533c8182bbf8155
https://doi.org/10.1016/0531-5565(96)00052-6
https://doi.org/10.1016/0531-5565(96)00052-6
Publikováno v:
Experimental Gerontology
The analysis of 26 longevity curves of different populations of inbred (Fischer 344) and outbred (Sprague-Dawley) rats highlighted a remarkable between-populations variability in survival parameters. This variability is independent of the breeding ch
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::46ba90a3a7e48d7ecafaefbe4438ba78
https://doi.org/10.1016/0531-5565(95)00002-x
https://doi.org/10.1016/0531-5565(95)00002-x