Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Orlando DeLeon"'
Autor:
Susanne Müller, Orlando DeLeon, Samantha N. Atkinson, Fatima Saravia, Stephanie Kellogg, Elizabeth A. Shank, John R. Kirby
Publikováno v:
Frontiers in Microbiology, Vol 14 (2023)
The soil-dwelling delta-proteobacterium Myxococcus xanthus is a model organism to study predation and competition. M. xanthus preys on a broad range of bacteria mediated by lytic enzymes, exopolysaccharides, Type-IV pilus-based motility, and speciali
Externí odkaz:
https://doaj.org/article/6223422fa8424a6e844b27f26e06ecd6
Autor:
Katya Frazier, Sumeed Manzoor, Katherine Carroll, Orlando DeLeon, Sawako Miyoshi, Jun Miyoshi, Marissa St. George, Alan Tan, Evan A. Chrisler, Mariko Izumo, Joseph S. Takahashi, Mrinalini C. Rao, Vanessa A. Leone, Eugene B. Chang
Publikováno v:
The Journal of Clinical Investigation, Vol 133, Iss 18 (2023)
Circadian rhythms govern glucose homeostasis, and their dysregulation leads to complex metabolic diseases. Gut microbes exhibit diurnal rhythms that influence host circadian networks and metabolic processes, yet underlying mechanisms remain elusive.
Externí odkaz:
https://doaj.org/article/2b3926a172264fbfb7638c31f72999c6
Autor:
Megan S. Kennedy, Manjing Zhang, Orlando DeLeon, Jacie Bissell, Florian Trigodet, Karen Lolans, Sara Temelkova, Katherine T. Carroll, Aretha Fiebig, Adam Deutschbauer, Ashley M. Sidebottom, Joash Lake, Chris Henry, Phoebe A. Rice, Joy Bergelson, Eugene B. Chang
Publikováno v:
Cell Reports, Vol 42, Iss 8, Pp 113009- (2023)
Summary: To understand how a bacterium ultimately succeeds or fails in adapting to a new host, it is essential to assess the temporal dynamics of its fitness over the course of colonization. Here, we introduce a human-derived commensal organism, Bact
Externí odkaz:
https://doaj.org/article/50674f85df064174bd593f77f0452143
Autor:
Valery V. Lozada-Fernández, Orlando deLeon, Stephanie L. Kellogg, Fatima L. Saravia, Matthew A. Hadiono, Samantha N. Atkinson, Justin L. Grobe, John R. Kirby
Publikováno v:
mSystems, Vol 7, Iss 1 (2022)
ABSTRACT The gut microbiome plays an essential role in host energy homeostasis and influences the development of obesity and related conditions. Studies demonstrate that nicotinamide riboside (NR) supplementation for diet-induced obesity (DIO) reduce
Externí odkaz:
https://doaj.org/article/65fc00ac2fb04dc49ce9e0a7f019431f
Autor:
Sarah M. Bahr, Benjamin J. Weidemann, Ana N. Castro, John W. Walsh, Orlando deLeon, Colin M.L. Burnett, Nicole A. Pearson, Daryl J. Murry, Justin L. Grobe, John R. Kirby
Publikováno v:
EBioMedicine, Vol 2, Iss 11, Pp 1725-1734 (2015)
Risperidone is a second-generation antipsychotic that causes weight gain. We hypothesized that risperidone-induced shifts in the gut microbiome are mechanistically involved in its metabolic consequences. Wild-type female C57BL/6J mice treated with ri
Externí odkaz:
https://doaj.org/article/0f99e99d40954192976e2669d56f7e91
Autor:
Orlando DeLeon, Hagit Hodis, Yunxia O'Malley, Jacklyn Johnson, Hamid Salimi, Yinjie Zhai, Elizabeth Winter, Claire Remec, Noah Eichelberger, Brandon Van Cleave, Ramya Puliadi, Robert D Harrington, Jack T Stapleton, Hillel Haim
Publikováno v:
PLoS Biology, Vol 15, Iss 4, p e2001549 (2017)
The envelope glycoproteins (Envs) of HIV-1 continuously evolve in the host by random mutations and recombination events. The resulting diversity of Env variants circulating in the population and their continuing diversification process limit the effi
Externí odkaz:
https://doaj.org/article/b600c1642ef54780a6ca2f16c13cab36
Autor:
Orlando deLeon, Jason M Puglise, Fengming Liu, Jos Smits, Martin B ter Beest, Mirjam M Zegers
Publikováno v:
PLoS ONE, Vol 7, Iss 7, p e41039 (2012)
The development of the basic architecture of branching tubules enclosing a central lumen that characterizes most epithelial organs crucially depends on the apico-basolateral polarization of epithelial cells. Signals from the extracellular matrix cont
Externí odkaz:
https://doaj.org/article/c021d202244249b8b409f7c1aabc4ccc
Autor:
Na Fei, Sawako Miyoshi, Jake B. Hermanson, Jun Miyoshi, Bingqing Xie, Orlando DeLeon, Maximilian Hawkins, William Charlton, Mark D’Souza, John Hart, Dinanath Sulakhe, Kristina B. Martinez-Guryn, Eugene B. Chang, Michael R. Charlton, Vanessa A. Leone
Publikováno v:
bioRxiv
SummaryNonalcoholic fatty liver disease (NAFLD) is multifactorial in nature, affecting over a billion people worldwide. The gut microbiome has emerged as an associative factor in NAFLD, yet mechanistic contributions are unclear. Here, we show fast fo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cd3301c3aa0186b869c8a7828b6fb8dc
https://europepmc.org/articles/PMC9882021/
https://europepmc.org/articles/PMC9882021/
Autor:
Katya Frazier, Sumeed Manzoor, Katherine Carroll, Orlando DeLeon, Sawako Miyoshi, Jun Miyoshi, Marissa St George, Alan Tan, Mariko Izumo, Joseph S. Takahashi, Mrinalini C. Rao, Vanessa A. Leone, Eugene B. Chang
SummaryCircadian rhythms govern glucose homeostasis, and their dysregulation leads to complex metabolic diseases. Gut microbes also exhibit diurnal rhythms that influence host circadian networks and metabolic processes, yet underlying mechanisms rema
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bb87b302e83790a8152c3cca166153be
https://doi.org/10.1101/2022.05.24.491361
https://doi.org/10.1101/2022.05.24.491361
Autor:
Manjing Zhang, Megan Kennedy, Orlando DeLeon, Jacie Bissell, Florian Trigodet, Karen Lolans, Sara Temelkova, Katherine T. Carroll, Aretha Fiebig, Adam Deutschbauer, Ashley M. Sidebottom, Chris Henry, Phoebe A. Rice, Joy Bergelson, Eugene B. Chang
To understand how a bacterium ultimately succeeds or fails in adapting to a new environment, it is essential to assess the temporal dynamics of its fitness over the course of colonization. The mammalian gut, into which exogenous microorganisms are re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0aafef42a93333bfc564a92d08f09bf9
https://doi.org/10.1101/2022.02.23.481734
https://doi.org/10.1101/2022.02.23.481734