Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Orland Gonzalez"'
Publikováno v:
PLoS ONE, Vol 9, Iss 9, p e107475 (2014)
Genomic analysis of H. salinarum indicated that the de novo pathway for aromatic amino acid (AroAA) biosynthesis does not follow the classical pathway but begins from non-classical precursors, as is the case for M. jannaschii. The first two steps in
Externí odkaz:
https://doaj.org/article/9aee1c61cce9410598cfe7041ce1ce05
Autor:
Philippa M Beard, Samantha J Griffiths, Orland Gonzalez, Ismar R Haga, Tali Pechenick Jowers, Danielle K Reynolds, Jan Wildenhain, Hille Tekotte, Manfred Auer, Mike Tyers, Peter Ghazal, Ralf Zimmer, Jürgen Haas
Publikováno v:
PLoS ONE, Vol 9, Iss 6, p e98431 (2014)
Vaccinia virus (VACV) is a large, cytoplasmic, double-stranded DNA virus that requires complex interactions with host proteins in order to replicate. To explore these interactions a functional high throughput small interfering RNA (siRNA) screen targ
Externí odkaz:
https://doaj.org/article/54e0675f17ff4ff48133bcd1756b2464
Autor:
Samantha J Griffiths, Manfred Koegl, Chris Boutell, Helen L Zenner, Colin M Crump, Francesca Pica, Orland Gonzalez, Caroline C Friedel, Gerald Barry, Kim Martin, Marie H Craigon, Rui Chen, Lakshmi N Kaza, Even Fossum, John K Fazakerley, Stacey Efstathiou, Antonio Volpi, Ralf Zimmer, Peter Ghazal, Jürgen Haas
Publikováno v:
PLoS Pathogens, Vol 9, Iss 8, p e1003514 (2013)
Herpes simplex virus type 1 (HSV-1) is a neurotropic virus causing vesicular oral or genital skin lesions, meningitis and other diseases particularly harmful in immunocompromised individuals. To comprehensively investigate the complex interaction bet
Externí odkaz:
https://doaj.org/article/c1319d0c08484c8a870675e878702559
Autor:
Orland Gonzalez, Tanja Oberwinkler, Locedie Mansueto, Friedhelm Pfeiffer, Eduardo Mendoza, Ralf Zimmer, Dieter Oesterhelt
Publikováno v:
PLoS Computational Biology, Vol 6, Iss 6, p e1000799 (2010)
Natronomonas pharaonis is an archaeon adapted to two extreme conditions: high salt concentration and alkaline pH. It has become one of the model organisms for the study of extremophilic life. Here, we present a genome-scale, manually curated metaboli
Externí odkaz:
https://doaj.org/article/31d299d1ed604ca59de6310004bbb31b
Autor:
Orland Gonzalez, Susanne Gronau, Friedhelm Pfeiffer, Eduardo Mendoza, Ralf Zimmer, Dieter Oesterhelt
Publikováno v:
PLoS Computational Biology, Vol 5, Iss 4, p e1000332 (2009)
Halobacterium salinarum is a bioenergetically flexible, halophilic microorganism that can generate energy by respiration, photosynthesis, and the fermentation of arginine. In a previous study, using a genome-scale metabolic model, we have shown that
Externí odkaz:
https://doaj.org/article/4d97b3b49b42427cbe575b9eeac54e3e
Autor:
Ralf Zimmer, Orland Gonzalez
Publikováno v:
Bioinformatics. 27:2707-2713
Motivation: Considerable attention has been directed in recent years toward the development of methods for the contextual analysis of expression data using interaction networks. Of particular interest has been the identification of active subnetworks
Autor:
Ralf Zimmer, Orland Gonzalez
Publikováno v:
Bioinformatics. 24:1257-1263
Motivation: A class of non-homology-based methods for protein function prediction relies on the assumption that genes linked to a phenotypic trait are preferentially conserved among organisms that share the trait. These methods typically compare pair
Autor:
Orland Gonzalez, Susanne von Gronau, Friedhelm Pfeiffer, Dieter Oesterhelt, Michaela Falb, Ralf Zimmer, Eduardo R. Mendoza
Publikováno v:
Mol. BioSyst.. 4:148-159
We present a genome-scale metabolic reconstruction for the extreme halophile Halobacterium salinarum. The reconstruction represents a summary of the knowledge regarding the organism's metabolism, and has already led to new research directions and imp
Publikováno v:
Bioinformatics. 23:480-486
Motivation: High-throughput technologies now allow the acquisition of biological data, such as comprehensive biochemical time-courses at unprecedented rates. These temporal profiles carry topological and kinetic information regarding the biochemical
Autor:
Hille Tekotte, Danielle K. Reynolds, Mike Tyers, Ralf Zimmer, Samantha J. Griffiths, Tali Pechenick Jowers, Jan Wildenhain, Manfred Auer, Orland Gonzalez, Philippa M. Beard, Peter Ghazal, Ismar R. Haga, Jürgen Haas
Publikováno v:
PLoS ONE
PLoS ONE, Vol 9, Iss 6, p e98431 (2014)
Beard, P M, Griffiths, S J, Gonzalez, O, Haga, I R, Pechenick-Jowers, T, Reynolds, D K, Wildenhain, J, Tekotte, H, Auer, M, Tyers, M, Ghazal, P, Zimmer, R & Haas, J 2014, ' A Loss of Function Analysis of Host Factors Influencing Vaccinia virus Replication by RNA Interference ', PLoS ONE, vol. 9, no. 6, e98431 . https://doi.org/10.1371/journal.pone.0098431
PLoS ONE, Vol 9, Iss 6, p e98431 (2014)
Beard, P M, Griffiths, S J, Gonzalez, O, Haga, I R, Pechenick-Jowers, T, Reynolds, D K, Wildenhain, J, Tekotte, H, Auer, M, Tyers, M, Ghazal, P, Zimmer, R & Haas, J 2014, ' A Loss of Function Analysis of Host Factors Influencing Vaccinia virus Replication by RNA Interference ', PLoS ONE, vol. 9, no. 6, e98431 . https://doi.org/10.1371/journal.pone.0098431
Vaccinia virus (VACV) is a large, cytoplasmic, double-stranded DNA virus that requires complex interactions with host proteins in order to replicate. To explore these interactions a functional high throughput small interfering RNA (siRNA) screen targ