Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Orla Rawley"'
Autor:
Orla Rawley, Laura L. Swystun, Christine Brown, Kate Nesbitt, Margaret Rand, Taneya Hossain, Robert Klaassen, Paula D. James, Manuel D. Carcao, David Lillicrap
Publikováno v:
Blood Advances. 6:2908-2919
von Willebrand factor (VWF) is an extremely cysteine-rich multimeric protein that is essential for maintaining normal hemostasis. The cysteine residues of VWF monomers form intra- and intermolecular disulfide bonds that regulate its structural confor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::265c317a805ed43dd93ad5f943b29627
https://doi.org/10.1182/bloodadvances.2021005928
https://doi.org/10.1182/bloodadvances.2021005928
Autor:
Ulrich Budde, Muhammad Ahmer Jamil, Orla Rawley, N. Marquardt, Hamideh Yadegari, David Lillicrap, Johannes Oldenburg, Jens Müller, Osman El-Maarri
Publikováno v:
Blood Advances. 6:1038-1053
An in-frame heterozygous large deletion of exons 4 through 34 of the von Willebrand factor (VWF) gene was identified in a type 3 von Willebrand disease (VWD) index patient (IP), as the only VWF variant. The IP exhibited severe bleeding episodes despi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::14823f19cdc82a030243c2df43446b24
https://doi.org/10.1182/bloodadvances.2021005895
https://doi.org/10.1182/bloodadvances.2021005895
Autor:
Edwin K. Ocran, Erin Burnett, Mackenzie L. Bowman, Orla Rawley, Matthew Cormier, Donald Maurice, David Lillicrap, Paula D. James
Publikováno v:
Blood. 140:11222-11223
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d124e647c380bf3f92e43425ef6ca371
https://doi.org/10.1182/blood-2022-159053
https://doi.org/10.1182/blood-2022-159053
Autor:
Mackenzie Bowman, Lara Casey, Soundarya N. Selvam, Patricia D.A. Lima, Orla Rawley, Megan Hinds, Angie Tuttle, Julie Grabell, Alfonso Iorio, Irwin Walker, David Lillicrap, Paula James
Publikováno v:
J Thromb Haemost
BACKGROUND: von Willebrand Factor (VWF) is synthesized by vascular endothelial cells and megakaryocytes. The VWF propeptide is critical for multimerization and acts as an intra-molecular chaperone for mature VWF in sorting to its storage organelles,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b886d4dc7b041dccdd5ac26fe33cf7bf
https://pubmed.ncbi.nlm.nih.gov/35466528
https://pubmed.ncbi.nlm.nih.gov/35466528
Autor:
Veerle Labarque, Christine E. Brown, Laura L. Swystun, Victor S. Blanchette, Ilinca Georgescu, Manuel Carcao, Christoph Male, Wilma M. Hopman, Orla Rawley, Katharina Thom, Kenichi Ogiwara, David Lillicrap
Publikováno v:
Blood. 134:880-891
Factor VIII (FVIII) pharmacokinetic (PK) properties show high interpatient variability in hemophilia A patients. Although previous studies have determined that age, body mass index, von Willebrand factor antigen (VWF:Ag) levels, and ABO blood group s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::15125759c25098ed57ea7bfff7f468c2
https://doi.org/10.1182/blood.2019000190
https://doi.org/10.1182/blood.2019000190
Autor:
David Lillicrap, Colleen Notley, Kate Nesbitt, Courtney Dwyer, Orla Rawley, Alison Michels, Laura L. Swystun
Publikováno v:
Journal of thrombosis and haemostasis : JTHREFERENCES. 19(10)
Background Stabilin-2 is an endocytic scavenger receptor that mediates the clearance of glycosaminoglycans, phosphatidylserine-expressing cells, and the von Willebrand factor-factor VIII (FVIII) complex. In a genome-wide screening study, pathogenic l
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4ee95379003ac1453bffbef08b60bf01
https://pubmed.ncbi.nlm.nih.gov/34152080
https://pubmed.ncbi.nlm.nih.gov/34152080
Autor:
Orla Rawley, David Lillicrap
Publikováno v:
Hamostaseologie. 41(1)
The primary polypeptide sequence of von Willebrand factor (VWF) includes an N-terminal 741-amino acid VWF propeptide (VWFpp). In cells expressing VWF, the VWFpp performs two critical functions. In the Golgi, VWFpp mediates the intermolecular disulfid
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::15770e8db4bf95a6ba712f4a150dcd52
https://pubmed.ncbi.nlm.nih.gov/33588457
https://pubmed.ncbi.nlm.nih.gov/33588457
Publikováno v:
Journal of Vascular Surgery. 74:e442
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4fd487ae67849e806d0f9390a409c1e3
https://doi.org/10.1016/j.jvs.2021.08.030
https://doi.org/10.1016/j.jvs.2021.08.030
Autor:
Laura L. Swystun, Karl Tryggvason, Kenichi Ogiwara, Alison Michels, Kate Nesbitt, David Lillicrap, Colleen Notley, Juha R.M. Ojala, Fanny Lassalle, Orla Rawley, Jesse D. Lai, Olle Rengby
Publikováno v:
J Thromb Haemost
Background Scavenger receptors play a significant role in clearing aged proteins from the plasma, including the large glycoprotein coagulation factors von Willebrand factor (VWF) and factor VIII (FVIII). A large genome-wide association study meta-ana
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4b2c437dd33bce529dfb0aba687b78c2
https://pubmed.ncbi.nlm.nih.gov/31126000
https://pubmed.ncbi.nlm.nih.gov/31126000
Autor:
Barry J. Byrne, Richard O’Kennedy, Teresa M. Brophy, Jamie M. O’Sullivan, Michelle Lavin, Orla Rawley, P. Vince Jenkins, Alain Chion, Kristina Gegenbauer, Roger J. S. Preston, James S. O’Donnell
Publikováno v:
Arteriosclerosis, Thrombosis, and Vascular Biology. 36:855-863
Objective— Recent studies have demonstrated that galectin-1 (Gal-1) and galectin-3 (Gal-3) can bind von Willebrand factor and directly modulate von Willebrand factor–dependent early thrombus formation in vivo. Because the glycans expressed on hum
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::42eac7a5dacedf98d257c66d2ad3fe91
https://doi.org/10.1161/atvbaha.115.306915
https://doi.org/10.1161/atvbaha.115.306915