Zobrazeno 1 - 10
of 65
pro vyhledávání: '"Orla Maguire"'
Autor:
Lauren Williams, Paul K Wallace, Pawel Kalinski, Mateusz Opyrchal, Kathleen M Kokolus, Shipra Gandhi, Kristopher Attwood, Agnieszka Witkiewicz, Hans Minderman, Kah Teong Soh, Melissa J Grimm, Ronald T Slomba, Adrienne Groman, Mary Lynne Tarquini, Orla Maguire, Tracey L O’Connor, Amy P Early, Ellis G Levine
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 11, Iss 11 (2023)
Background Presence of cytotoxic T lymphocytes (CTL) in the tumor microenvironment (TME) predicts the effectiveness of cancer immunotherapies. The ability of toll-like receptor 3 (TLR3) ligands, interferons (IFNs) and COX2 inhibitors to synergistical
Externí odkaz:
https://doaj.org/article/2d1ecf8be6c34222ae25dc9f47cf3dc6
Autor:
Shraddha Sharma, Jianmin Wang, Emad Alqassim, Scott Portwood, Eduardo Cortes Gomez, Orla Maguire, Per H. Basse, Eunice S. Wang, Brahm H. Segal, Bora E. Baysal
Publikováno v:
Genome Biology, Vol 20, Iss 1, Pp 1-17 (2019)
Abstract Background Protein recoding by RNA editing is required for normal health and evolutionary adaptation. However, de novo induction of RNA editing in response to environmental factors is an uncommon phenomenon. While APOBEC3A edits many mRNAs i
Externí odkaz:
https://doaj.org/article/4cb51bbdf793402da1a28e36fd3f9e70
Autor:
Richard B. Bankert, Sathy V. Balu-Iyer, Kunle Odunsi, Paul K. Wallace, Hans Minderman, Raymond J. Kelleher, Vandana Iyer, Orla Maguire, Jenni Loyall, Gautam N. Shenoy
Nano-sized membrane-encapsulated extracellular vesicles isolated from the ascites fluids of ovarian cancer patients are identified as exosomes based on their biophysical and compositional characteristics. We report here that T cells pulsed with these
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7b1da959f1a7a206f3dc6cb63adc7f24
https://doi.org/10.1158/2326-6066.c.6548932.v1
https://doi.org/10.1158/2326-6066.c.6548932.v1
Autor:
Richard B. Bankert, Sathy V. Balu-Iyer, Kunle Odunsi, Paul K. Wallace, Hans Minderman, Raymond J. Kelleher, Vandana Iyer, Orla Maguire, Jenni Loyall, Gautam N. Shenoy
List of reagents used in flow cytometry and fluorescence microscopy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2f285b633cf4a332366dfcaf7479b6f7
https://doi.org/10.1158/2326-6066.22538890
https://doi.org/10.1158/2326-6066.22538890
Autor:
Richard B. Bankert, Sathy V. Balu-Iyer, Kunle Odunsi, Paul K. Wallace, Hans Minderman, Raymond J. Kelleher, Vandana Iyer, Orla Maguire, Jenni Loyall, Gautam N. Shenoy
S1: Exosome derived from different ascites fluids show varying degrees of inhibition. S2: Exosomes do not affect T cell death following activation. S3: Exosomes inhibit IL-2 production by T cells. S4: Exosomes inhibit IFN-gamma production by T cells.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::10fce715e7f5f86b91eb80275dc7fbe8
https://doi.org/10.1158/2326-6066.22538893.v1
https://doi.org/10.1158/2326-6066.22538893.v1
Autor:
Patrick M. Boland, Renuka Iyer, Pawel Kalinski, Jennifer A. Jurcevic, Karen A. Hicks, Kristopher Attwood, Alan D. Hutson, Chong Wang, Scott I. Abrams, Jason B. Muhitch, Erik S. Knudsen, Hanna R. Rosenheck, Ram Nambiar, Hans Minderman, Orla Maguire, Agnieszka K. Witkiewicz, Joel Saltzman, Sarbajit Mukherjee, David L. Bajor, Christos Fountzilas
T-cell infiltration for patient LH-01-26 with BRAF V600 mutation in comparison to study population
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8353c4f2e2360c24923a91498af6f545
https://doi.org/10.1158/1078-0432.22482590.v1
https://doi.org/10.1158/1078-0432.22482590.v1
Autor:
Patrick M. Boland, Renuka Iyer, Pawel Kalinski, Jennifer A. Jurcevic, Karen A. Hicks, Kristopher Attwood, Alan D. Hutson, Chong Wang, Scott I. Abrams, Jason B. Muhitch, Erik S. Knudsen, Hanna R. Rosenheck, Ram Nambiar, Hans Minderman, Orla Maguire, Agnieszka K. Witkiewicz, Joel Saltzman, Sarbajit Mukherjee, David L. Bajor, Christos Fountzilas
Multispectral immunofluorescence. Number of cells positive for exhaustion (PD-L1, TIM3, LAG3, CTLA4) and activation markers (OX40) in baseline tumor specimens (A); Quantitation of signals per specimen (B). There are more PDL1 positive tumor cell in t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0593ee4c25f03ae86a60bf0b6fbe151b
https://doi.org/10.1158/1078-0432.22482602
https://doi.org/10.1158/1078-0432.22482602
Autor:
Patrick M. Boland, Renuka Iyer, Pawel Kalinski, Jennifer A. Jurcevic, Karen A. Hicks, Kristopher Attwood, Alan D. Hutson, Chong Wang, Scott I. Abrams, Jason B. Muhitch, Erik S. Knudsen, Hanna R. Rosenheck, Ram Nambiar, Hans Minderman, Orla Maguire, Agnieszka K. Witkiewicz, Joel Saltzman, Sarbajit Mukherjee, David L. Bajor, Christos Fountzilas
Consort Diagram.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::93254bad61f40c2366abc9d865667816
https://doi.org/10.1158/1078-0432.22482611
https://doi.org/10.1158/1078-0432.22482611
Autor:
Patrick M. Boland, Renuka Iyer, Pawel Kalinski, Jennifer A. Jurcevic, Karen A. Hicks, Kristopher Attwood, Alan D. Hutson, Chong Wang, Scott I. Abrams, Jason B. Muhitch, Erik S. Knudsen, Hanna R. Rosenheck, Ram Nambiar, Hans Minderman, Orla Maguire, Agnieszka K. Witkiewicz, Joel Saltzman, Sarbajit Mukherjee, David L. Bajor, Christos Fountzilas
Intratumoral NK cells (baseline) by change in tumor size (A) and change in CEA (B).
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::21356901729a3819e64396a350c9cd4c
https://doi.org/10.1158/1078-0432.22482605
https://doi.org/10.1158/1078-0432.22482605
Autor:
Patrick M. Boland, Renuka Iyer, Pawel Kalinski, Jennifer A. Jurcevic, Karen A. Hicks, Kristopher Attwood, Alan D. Hutson, Chong Wang, Scott I. Abrams, Jason B. Muhitch, Erik S. Knudsen, Hanna R. Rosenheck, Ram Nambiar, Hans Minderman, Orla Maguire, Agnieszka K. Witkiewicz, Joel Saltzman, Sarbajit Mukherjee, David L. Bajor, Christos Fountzilas
Correlate of baseline and on-treatment changes in intratumoral immune cells (flow cytometry) with clinical endpoints (Supplementary Table 2A), immune checkpoint expression by multispectral immunofluorescence in tumor microenvironment (Supplementary T
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4656dbdd368cd80c10f0a4e81f4b7124
https://doi.org/10.1158/1078-0432.22482593.v1
https://doi.org/10.1158/1078-0432.22482593.v1