Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Orla M. Phillips"'
Publikováno v:
Journal of Neurochemistry. 54:1275-1280
5-Hydroxytryptamine (5-HT) showed a biphasic effect on the dissociation rate of [3H]imipramine from human platelet membranes: At low concentrations (EC50, approximately 2.5 microM), 5-HT stimulated the rate, as expected for mutually exclusive binding
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::69f336d2903e06464abbddabfbaecf56
https://doi.org/10.1111/j.1471-4159.1990.tb01959.x
https://doi.org/10.1111/j.1471-4159.1990.tb01959.x
Publikováno v:
Biochemical Pharmacology. 39:507-511
A murine monoclonal antibody raised using imipramine conjugated to bovine serum albumin bound free imipramine with high affinity ( k d ) = 24 nM). The antibody had a binding affinity profile for tricyclic and other uptake-inhibitor type antidepressan
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7ea68480a90f81bb64eac8280fa9e1e4
https://doi.org/10.1016/0006-2952(90)90057-r
https://doi.org/10.1016/0006-2952(90)90057-r
Autor:
Timothy J. Mantle, Miles D. Houslay, Alan R. Tuffery, Clare M. Heyworth, S R Wilson, Orla M. Phillips
Publikováno v:
Biochemical Pharmacology. 33:1963-1967
Contrary to a recent report by Okazaki et al. (Biochem. biophys. Res. Commun., 1978, 81, 512-520) we show that high concentrations of biliverdin (100 mg/kg, i.p.) slightly reduce the mitotic rate in rat liver. Adenylate cyclase and both the "high Km"
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3fa2a15cb4343cceb3610e716edab896
https://doi.org/10.1016/0006-2952(84)90556-2
https://doi.org/10.1016/0006-2952(84)90556-2
Publikováno v:
Journal of Neurochemistry. 49:1091-1095
Antisera against 2-aminoimipramine covalently coupled to albumin have been raised in two rabbits. Both antisera bind imipramine and related tricyclic compounds as if to a single class of sites with high affinity and high litres. Displacement/inhibiti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::98ae5c5c15fbb583985be1bf7cd43283
https://doi.org/10.1111/j.1471-4159.1987.tb09998.x
https://doi.org/10.1111/j.1471-4159.1987.tb09998.x
Publikováno v:
Biochemical Journal. 255:431-435
The liver, kidney and spleen of the mouse and rat and the kidney and spleen of the ox express a monomeric form of biliverdin reductase (Mr 34,000), which in the case of the ox kidney enzyme exists in two forms (pI 5.4 and 5.2) that are probably charg
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9365251be1f7e3a9b4d2bcd903680bd4
https://doi.org/10.1042/bj2550431
https://doi.org/10.1042/bj2550431
Publikováno v:
Journal of Neurochemistry. 43:479-486
Apparent specific binding of [3H]imipramine to human platelet membranes at high concentrations of imipramine showed deviation from that expected of a single binding site, a result consistent with a low-affinity binding site. The deviation was due to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::69dac7d2ededd0cc35b7068961a406da
https://doi.org/10.1111/j.1471-4159.1984.tb00924.x
https://doi.org/10.1111/j.1471-4159.1984.tb00924.x
Autor:
Orla M. Phillips, D. C. Williams
Publikováno v:
Journal of Neurochemistry. 45:661-663
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1772aea0644b2c04c68d335014653759
https://doi.org/10.1111/j.1471-4159.1985.tb04043.x
https://doi.org/10.1111/j.1471-4159.1985.tb04043.x
Autor:
Orla M. Phillips, Timothy J. Mantle
Publikováno v:
Biochemical Society transactions. 9(4)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6eb73cf2d02c0f0652f5e067997de634
https://pubmed.ncbi.nlm.nih.gov/7262442
https://pubmed.ncbi.nlm.nih.gov/7262442
Publikováno v:
European journal of pharmacology. 146(2-3)
Sertraline, a new selective 5-HT uptake inhibitor showed a mixed pattern of inhibition of human platelet 5-HT uptake with a Ki value of 2.5 nM and Ki′ value of 25 nM. Imipramine and alaproclate were found to be fully competitive inhibitors of 5-HT
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cd77be1cbbe0e29e04b747376a118078
https://pubmed.ncbi.nlm.nih.gov/3371401
https://pubmed.ncbi.nlm.nih.gov/3371401
Publikováno v:
Biochemical Society Transactions. 15:274-275
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d8a8d86a5472f8f61881ee3399e259f7
https://doi.org/10.1042/bst0150274a
https://doi.org/10.1042/bst0150274a