Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Orkide O. Koyuncu"'
Publikováno v:
Viruses, Vol 15, Iss 12, p 2284 (2023)
Alpha herpesvirus infections (α-HVs) are widespread, affecting more than 70% of the adult human population. Typically, the infections start in the mucosal epithelia, from which the viral particles invade the axons of the peripheral nervous system. I
Externí odkaz:
https://doaj.org/article/95d260301a104f839d11d1249a7501f9
Publikováno v:
Pathogens, Vol 12, Iss 9, p 1142 (2023)
Alpha herpesviruses (α-HV) infect host mucosal epithelial cells prior to establishing a life-long latent infection in the peripheral nervous system. The initial spread of viral particles from mucosa to the nervous system and the role of intrinsic im
Externí odkaz:
https://doaj.org/article/5f3cb533080240e1ac9a69d4888e7ab8
Autor:
Ren Song, Orkide O. Koyuncu, Todd M. Greco, Benjamin A. Diner, Ileana M. Cristea, Lynn W. Enquist
Publikováno v:
mBio, Vol 7, Iss 1 (2016)
ABSTRACT Infection by alphaherpesviruses, including herpes simplex virus (HSV) and pseudorabies virus (PRV), typically begins at epithelial surfaces and continues into the peripheral nervous system (PNS). Inflammatory responses are induced at the inf
Externí odkaz:
https://doaj.org/article/9b87fab9a02049da9e10275212c26540
Publikováno v:
mBio, Vol 6, Iss 2 (2015)
ABSTRACT Infection by alphaherpesviruses invariably results in invasion of the peripheral nervous system (PNS) and establishment of either a latent or productive infection. Infection begins with long-distance retrograde transport of viral capsids and
Externí odkaz:
https://doaj.org/article/241249ef2c2c4e709968a4899ea0fb10
Autor:
Shane J. F. Cronin, Miguel A. Tejada, Ren Song, Kathlyn Laval, Domagoj Cikes, Ming Ji, Annalaura Brai, Johannes Stadlmann, Maria Novatchikova, Thomas Perlot, Omar Hasan Ali, Lorenzo Botta, Thomas Decker, Jelena Lazovic, Astrid Hagelkruys, Lynn Enquist, Shuan Rao, Orkide O. Koyuncu, Josef M. Penninger
Infections with defined Herpesviruses, such as Pseudorabies virus (PRV) and Varicella zoster virus (VZV) can cause neuropathic itch, referred to as “mad itch” in multiple species. The underlying mechanisms involved in neuropathic “mad itch” a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bff066a5f58b02d4125b43795f2f0413
https://doi.org/10.1101/2023.05.09.539956
https://doi.org/10.1101/2023.05.09.539956
Alpha herpesvirus (α-HV) particles enter their hosts from mucosal surfaces and efficiently maintain fast transport in peripheral nervous system (PNS) axons to establish infections in the peripheral ganglia. The path from axons to distant neuronal nu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4df6988da4d34fc0100b19e2626e14aa
https://doi.org/10.1101/2023.01.13.524029
https://doi.org/10.1101/2023.01.13.524029
Autor:
Margaret A MacGibeny, Orkide O Koyuncu, Christoph Wirblich, Matthias J Schnell, Lynn W Enquist
Publikováno v:
PLoS Pathogens, Vol 14, Iss 7, p e1007188 (2018)
Neuroinvasive viruses, such as alpha herpesviruses (αHV) and rabies virus (RABV), initially infect peripheral tissues, followed by invasion of the innervating axon termini. Virus particles must undergo long distance retrograde axonal transport to re
Externí odkaz:
https://doaj.org/article/f27b3205bfcb413a8cbed83fdacb514c
Publikováno v:
PLoS Pathogens, Vol 13, Iss 10, p e1006608 (2017)
Alpha herpesvirus genomes encode the capacity to establish quiescent infections (i.e. latency) in the peripheral nervous system for the life of their hosts. Multiple times during latency, viral genomes can reactivate to start a productive infection,
Externí odkaz:
https://doaj.org/article/d754fc43169e4fe7b51917f94c5f497d
Publikováno v:
Journal of virology, vol 96, iss 5
Infection of peripheral axons by alpha herpesviruses (AHVs) is a critical stage in establishing a life-long infection in the host. Upon entering the cytoplasm of axons, AHV nucleocapsids and associated inner-tegument proteins must engage the cellular
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::527f668a8dfc743997ad34868ae384fe
https://escholarship.org/uc/item/3j63h7kw
https://escholarship.org/uc/item/3j63h7kw
Publikováno v:
Journal of Virology
JOURNAL OF VIROLOGY
JOURNAL OF VIROLOGY
Alphaherpesviruses have mastered various strategies to persist in an immunocompetent host, including the induction of latency and reactivation in peripheral nervous system (PNS) ganglia. We recently discovered that the molecular mechanism underlying
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3508f73a51d1a4ff5f40770e83f83b8e
http://europepmc.org/articles/PMC8094956
http://europepmc.org/articles/PMC8094956