Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Orit Lache"'
Autor:
Rachel A. Warren, Allie S. Carew, Pantelis Andreou, Andrew P. Levy, John Sapp, Orit Lache, Henry N. Ginsberg, Eric B. Rimm, Christine Herman, Susan Kirkland, Leah E. Cahill
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 12, Iss 19 (2023)
Background The Hp (haptoglobin)2‐2 phenotype (~40% of people) is associated with dysfunctional high‐density lipoprotein (HDL) that is heavily oxidized in hyperglycemia, which may explain why raising HDL‐cholesterol (HDL‐C) does not reliably p
Externí odkaz:
https://doaj.org/article/ccd7a91d532d4890b6c99ea458e7c867
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 5, p 4984 (2023)
Recent insights into IQSEC2 disease are summarized in this review as follows: (1) Exome sequencing of IQSEC2 patient DNA has led to the identification of numerous missense mutations that delineate at least six and possibly seven essential functional
Externí odkaz:
https://doaj.org/article/bb1301876c6349ee9abf66a861523f63
Publikováno v:
International Journal of Molecular Sciences, Vol 20, Iss 12, p 3038 (2019)
Mutations in IQSEC2 cause intellectual disability (ID), which is often accompanied by seizures and autism. A number of studies have shown that IQSEC2 is an abundant protein in excitatory synapses and plays an important role in neuronal development as
Externí odkaz:
https://doaj.org/article/e4ba3c0c79a44346829aaef1ee587faf
Autor:
Eric B. Rimm, Robert P. Byington, Andrew P. Levy, Martin J. Gardner, Leah E. Cahill, Steven G. Coca, Orit Lache, Thomas Ransom, Allie S. Carew, John L. Sapp, Henry N. Ginsberg
Publikováno v:
Journal of the American College of Cardiology. 75:512-521
Background Whereas there exists a direct relationship between glycated hemoglobin and cardiovascular disease (CVD), clinical trials targeting glycated hemoglobin to near-normal levels using intensive therapy have failed to prevent CVD and have even i
Autor:
Sagee, Tal, Yochai, Adir, Nili, Stein, Hadar, Shalom, Orit, Lache, Andrew, Levy, Michal, Shteinberg
Publikováno v:
The Israel Medical Association journal : IMAJ. 21(1)
Frequent chronic obstructive pulmonary disease (COPD) exacerbators are at a higher risk of adverse health outcomes when compared to infrequent exacerbators. A COPD frequent exacerbator phenotype and its definition has been reported. Haptoglobin (Hp)
Publikováno v:
International Journal of Molecular Sciences
International Journal of Molecular Sciences, Vol 20, Iss 12, p 3038 (2019)
International Journal of Molecular Sciences, Vol 20, Iss 12, p 3038 (2019)
Mutations in IQSEC2 cause intellectual disability (ID), which is often accompanied by seizures and autism. A number of studies have shown that IQSEC2 is an abundant protein in excitatory synapses and plays an important role in neuronal development as
Autor:
Carey E. Gleason, Orit Lache, Barbara B. Bendlin, Ramit Ravona-Springer, Michal Schnaider Beeri, Andrew P. Levy, Scott Ehrenberg, Laili Soleimani, Elizabeth Guerrero-Berroa, Yaakov K. Seligman, Lenore J. Launer, Mary Sano, Hung-Mo Lin, Xiaoyu Liu
Publikováno v:
JAMA Network Open. 1:e184458
Importance African American individuals have higher dementia risk than individuals of white race/ethnicity. They also have higher rates of type 2 diabetes, which may contribute to this elevated risk. This study examined the association of the followi
Autor:
Bhupinder Bharaj, Shany Blum, Nina S. Levy, Andrew P. Levy, Patricia A. Cleary, Janet K. Snell-Bergeon, Marian Rewers, Orit Lache, Rachel Miller-Lotan, Yefim Afinbinder, Moshe Vardi, Andrew D. Paterson
Publikováno v:
Clinical Chemistry and Laboratory Medicine (CCLM). 51:1615-1622
Background: Haptoglobin (Hp) is an abundant serum protein which binds extracorpuscular hemoglobin (Hb). Two alleles exist in humans for the Hp gene, denoted 1 and 2. Diabetic individuals with the Hp 2-2 genotype are at increased risk of developing va
Autor:
Osher Cohen, Julia Guetta, Ofer Binah, Andrew P. Levy, Mark Shilkrut, Yoram Kanter, Nina S. Levy, Naim Shehadeh, Orit Lache, Stuart Marsh, Rabea Asleh, Ben Enav, Flavio Lejbkowicz
Publikováno v:
Circulation Research. 92:1193-1200
A major function of haptoglobin (Hp) is to bind hemoglobin (Hb) to form a stable Hp-Hb complex and thereby prevent Hb-induced oxidative tissue damage. Clearance of the Hp-Hb complex can be mediated by the monocyte/macrophage scavenger receptor CD163.
Autor:
Zaid Abassi, Eviatar Nevo, Samy Nitecki, Orit Lache, Nina S. Levy, Ariel Roguin, Aaron Avivi, Irit Rubinstein, Aaron Hoffman, Andrew P. Levy, Murray B. Resnick, Meira Melamed-Frank, Alma Joel
Publikováno v:
Proceedings of the National Academy of Sciences. 100:4644-4648
The optimal vector, regulatory sequences, and method of delivery of angiogenic gene therapy are of considerable interest. The Spalax ehrenbergi superspecies live in subterranean burrows at low oxygen tensions and its tissues are highly vascularized.