Výsledky vyhledávání - "Orit Bar‐Am"

Akademický článek

Cell driven elastomeric particle packing in composite bioinks for engineering and implantation of stable 3D printed structures

Autor: Shira Landau, Jennifer Kieda, Ramak Khosravi, Sargol Okhovatian, Kaitlyn Ramsay, Chuan Liu, Amid Shakeri, Yimu Zhao, Karen Shen, Orit Bar-Am, Shulamit Levenberg, Scott Tsai, Milica Radisic

Publikováno v: Bioactive Materials, Vol 44, Iss , Pp 411-427 (2025)

Geometric and structural integrity often deteriorate in 3D printed cell-laden constructs over time due to cellular compaction and hydrogel shrinkage. This study introduces a new approach that synergizes the advantages of cell compatibility of biologi

Externí odkaz: https://doaj.org/article/9c46c285178c494380436e3d082de4ac

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Akademický článek

Placenta‐Derived Mesenchymal Stromal‐Like Cells Promote 3D‐Engineered Muscle Tissue Differentiation and Vessel Network Maturation

Autor: Anna Tsukerman, Majd Machour, Margarita Shuhmaher, Eliana O. Fischer, Hagit Shoyhet, Orit Bar‐Am, Gali Guterman Ram, Lior Debbi, Dina Safina, Shulamit Levenberg

Publikováno v: Small Science, Vol 4, Iss 11, Pp n/a-n/a (2024)

Placental‐derived stromal‐like cells (PLX‐PAD) have been shown to facilitate muscle tissue recovery after injury and stimulate angiogenesis. This work assesses the impact of PLX‐PAD cells on the vascularization and maturation of engineered sk

Externí odkaz: https://doaj.org/article/734de8b78e49449f9b0afbfad6684639

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Akademický článek

Development of a local controlled release system for therapeutic proteins in the treatment of skeletal muscle injuries and diseases

Autor: Rachel Lev, Orit Bar-Am, Galit Saar, Ombretta Guardiola, Gabriella Minchiotti, Eli Peled, Dror Seliktar

Publikováno v: Cell Death and Disease, Vol 15, Iss 7, Pp 1-15 (2024)

Abstract The present study aims to develop and characterize a controlled-release delivery system for protein therapeutics in skeletal muscle regeneration following an acute injury. The therapeutic protein, a membrane-GPI anchored protein called Cript

Externí odkaz: https://doaj.org/article/d8147ccd6f804fce8f03a5da4fabc7d7

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Akademický článek

In vivo restoration of dystrophin expression in mdx mice using intra-muscular and intra-arterial injections of hydrogel microsphere carriers of exon skipping antisense oligonucleotides

Autor: Shani Attias Cohen, Orit Bar-Am, Claudia Fuoco, Galit Saar, Cesare Gargioli, Dror Seliktar

Publikováno v: Cell Death and Disease, Vol 13, Iss 9, Pp 1-13 (2022)

Abstract Duchenne muscular dystrophy (DMD) is a genetic disease caused by a mutation in the X-linked Dytrophin gene preventing the expression of the functional protein. Exon skipping therapy using antisense oligonucleotides (AONs) is a promising ther

Externí odkaz: https://doaj.org/article/fe0013a595db4cceab2c7023d034c82e

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Akademický článek

Biomanufacturing Recombinantly Expressed Cripto-1 Protein in Anchorage-Dependent Mammalian Cells Growing in Suspension Bioreactors within a Three-Dimensional Hydrogel Microcarrier

Autor: Rachel Lev, Orit Bar-Am, Yoni Lati, Ombretta Guardiola, Gabriella Minchiotti, Dror Seliktar

Publikováno v: Gels, Vol 9, Iss 3, p 243 (2023)

Biotherapeutic soluble proteins that are recombinantly expressed in mammalian cells can pose a challenge when biomanufacturing in three-dimensional (3D) suspension culture systems. Herein, we tested a 3D hydrogel microcarrier for a suspension culture

Externí odkaz: https://doaj.org/article/bbc4fff76e844e35a24e10c56a4f295f

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Akademický článek

Correction: I Imidazoline Receptor: Novel Potential Cytoprotective Target of TVP1022, the S-Enantiomer of Rasagiline.

Autor: Yaron D. Barac, Orit Bar-Am, Esti Liani, Tamar Amit, Luba Frolov, Elena Ovcharenko, Itzchak Angel, Moussa B. H. Youdim, Ofer Binah

Publikováno v: PLoS ONE, Vol 8, Iss 6 (2013)

Externí odkaz: https://doaj.org/article/dd182bbe221d422c884a954cc4cff70f

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Akademický článek

I1 imidazoline receptor: novel potential cytoprotective target of TVP1022, the S-enantiomer of rasagiline.

Autor: Yaron D Barac, Orit Bar-Am, Esti Liani, Tamar Amit, Luba Frolov, Elena Ovcharenko, Itzchak Angel, Moussa B H Youdim, Ofer Binah

Publikováno v: PLoS ONE, Vol 7, Iss 11, p e47890 (2012)

TVP1022, the S-enantiomer of rasagiline (Azilect®) (N-propargyl-1R-aminoindan), exerts cyto/cardio-protective effects in a variety of experimental cardiac and neuronal models. Previous studies have demonstrated that the protective activity of TVP102

Externí odkaz: https://doaj.org/article/5f118b38e1ff4e3085d81f99839f6506

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