Zobrazeno 1 - 10
of 44
pro vyhledávání: '"Orion Shih"'
Autor:
Tien-Chang Lin, Orion Shih, Tien-Ying Tsai, Yi-Qi Yeh, Kuei-Fen Liao, Bradley W. Mansel, Ying-Jen Shiu, Chi-Fon Chang, An-Chung Su, Yun-Ru Chen, U-Ser Jeng
Publikováno v:
IUCrJ, Vol 11, Iss 5, Pp 849-858 (2024)
The aberrant fibrillization of huntingtin exon 1 (Httex1) characterized by an expanded polyglutamine (polyQ) tract is a defining feature of Huntington's disease, a neurodegenerative disorder. Recent investigations underscore the involvement of a smal
Externí odkaz:
https://doaj.org/article/209dc44d9cfb417082cdde097083b7a8
Autor:
Mei-Hui Hou, Yu-Chuan Wang, Chia-Shin Yang, Kuei-Fen Liao, Je-Wei Chang, Orion Shih, Yi-Qi Yeh, Manoj Kumar Sriramoju, Tzu-Wen Weng, U-Ser Jeng, Shang-Te Danny Hsu, Yeh Chen
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-15 (2023)
Abstract The cyclic GMP-AMP synthase (cGAS)/stimulator of interferon gene (STING) signaling pathway plays a critical protective role against viral infections. Metazoan STING undergoes multilayers of regulation to ensure specific signal transduction.
Externí odkaz:
https://doaj.org/article/ca986528205f4ec69d407be288059425
Autor:
Tien-Ying Tsai, Chun-Yu Chen, Tien-Wei Lin, Tien-Chang Lin, Feng-Lan Chiu, Orion Shih, Ming-Yun Chang, Yu-Chun Lin, An-Chung Su, Chiung-Mei Chen, U-Ser Jeng, Hung-Chih Kuo, Chi-Fon Chang, Yun-Ru Chen
Publikováno v:
Communications Biology, Vol 7, Iss 1, Pp 1-1 (2024)
Externí odkaz:
https://doaj.org/article/23195256cee845cba07ecc78881ccb80
Autor:
Tien-Ying Tsai, Chun-Yu Chen, Tien-Wei Lin, Tien-Chang Lin, Feng-Lan Chiu, Orion Shih, Ming-Yun Chang, Yu-Chun Lin, An-Chung Su, Chiung-Mei Chen, U-Ser Jeng, Hung-Chih Kuo, Chi-Fon Chang, Yun-Ru Chen
Publikováno v:
Communications Biology, Vol 6, Iss 1, Pp 1-16 (2023)
Abstract Abnormal polyglutamine (polyQ) expansion and fibrillization occur in Huntington’s disease (HD). Amyloid modifier SERF enhances amyloid formation, but the underlying mechanism is not revealed. Here, the fibrillization and toxicity effect of
Externí odkaz:
https://doaj.org/article/6e87385b553749fe86bdfe7efeea0311
Autor:
Hong Thuy Vy Nguyen, Xiaorui Chen, Claudia Parada, An-Chi Luo, Orion Shih, U-Ser Jeng, Chia-Ying Huang, Yu-Ling Shih, Che Ma
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-13 (2023)
The FtsB-FtsL-FtsQ complex is essential for regulating cell wall synthesis during bacterial cell division. Here, authors report the full-length trimeric structure showing a tilted V-shaped conformation and suggest an allosteric regulatory mechanism.
Externí odkaz:
https://doaj.org/article/ea9125c01b5f4c17b41219e5cbe79619
Autor:
Tien-Ying Tsai, Chun-Yu Chen, Tien-Wei Lin, Tien-Chang Lin, Feng-Lan Chiu, Orion Shih, Ming-Yun Chang, Yu-Chun Lin, An-Chung Su, Chiung-Mei Chen, U-Ser Jeng, Hung-Chih Kuo, Chi-Fon Chang, Yun-Ru Chen
Publikováno v:
Communications Biology, Vol 6, Iss 1, Pp 1-1 (2023)
Externí odkaz:
https://doaj.org/article/f4ca8793b2a14fec90efec80ad653915
Autor:
Yee Song Law, Yaw Bia Tan, Orion Shih, Age Utt, Jie Zheng, Sainan Wang, Ming Wei Chen, Patrick R. Griffin, U-Ser Jeng, Andres Merits, Dahai Luo
Publikováno v:
Proceedings, Vol 50, Iss 1, p 113 (2020)
Chikungunya virus (CHIKV) is transmitted to humans through mosquitoes and causes Chikungunya fever. Nonstructural protein 2 (nsP2) contains an N-terminal RNA helicase with both nucleotide triphosphatase and RNA triphosphatase activities, and a C-term
Externí odkaz:
https://doaj.org/article/dd0e57e9f5c049399e471f1fc3668f60
Autor:
Hung-Wei Yeh, Po-Pang Chen, Tzu-Chen Yeh, Shiou-Lan Lin, Yue-Ting Chen, Wan-Ping Lin, Ting Chen, Jia Meng Pang, Kai-Ti Lin, Lily Hui-Ching Wang, Yu-Chun Lin, Orion Shih, U-Ser Jeng, Kuo-Chiang Hsia, Hui-Chun Cheng
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America; 6/18/2024, Vol. 121 Issue 25, p1-12, 33p
Autor:
Chia-Lung Tsai, Je-Wei Chang, Kum-Yi Cheng, Yu-Jing Lan, Yi-Cheng Hsu, Qun-Da Lin, Tzu-Yuan Chen, Orion Shih, Chih-Hsun Lin, Po-Hsun Chiang, Simenas, Mantas, Kalendra, Vidmantas, Yun-Wei Chiang, Chun-hsien Chen, U-Ser Jeng, Sheng-Kai Wang
Publikováno v:
Nanoscale Advances; 2/7/2024, Vol. 6 Issue 3, p947-959, 13p
Publikováno v:
Langmuir. 38:5987-5995