Zobrazeno 1 - 10
of 37
pro vyhledávání: '"Oriol Iborra-Egea"'
Autor:
Alberto Aimo, Oriol Iborra-Egea, Nicola Martini, Carolina Galvez-Monton, Silvia Burchielli, Giorgia Panichella, Claudio Passino, Michele Emdin, Antoni Bayes-Genis
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-11 (2022)
Abstract Left ventricular (LV) remodeling after myocardial infarction (MI) is promoted by an intense fibrotic response, which could be targeted by the anti-fibrotic drug pirfenidone. We explored the relationship between protein modulation by pirfenid
Externí odkaz:
https://doaj.org/article/8e6ee7b588cb4afaa6b879af41f8288d
Autor:
Antoni Bayes-Genis, Oriol Iborra-Egea, Giosafat Spitaleri, Mar Domingo, Elena Revuelta-López, Pau Codina, Germán Cediel, Evelyn Santiago-Vacas, Adriana Cserkóová, Domingo Pascual-Figal, Julio Núñez, Josep Lupón
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-9 (2021)
Abstract The use of sodium-glucose co-transporter 2 inhibitors to treat heart failure with preserved ejection fraction (HFpEF) is under investigation in ongoing clinical trials, but the exact mechanism of action is unclear. Here we aimed to use artif
Externí odkaz:
https://doaj.org/article/25cc0ca35f374ccaaf5bcf8cbf852ee7
Autor:
Oriol Iborra-Egea, Alberto Aimo, Nicola Martini, Carolina Galvez-Monton, Silvia Burchielli, Giorgia Panichella, Claudio Passino, Michele Emdin, Antoni Bayes-Genis
Publikováno v:
Frontiers in Cardiovascular Medicine, Vol 9 (2022)
BackgroundLeft ventricular (LV) remodeling consists in maladaptive changes in cardiac geometry and function following an insult such as ST-segment elevation myocardial infarction (STEMI). Interventions able to prevent LV remodeling after a STEMI are
Externí odkaz:
https://doaj.org/article/3d062473f2c34d35bd52cd3ff73bbf58
Publikováno v:
Frontiers in Cardiovascular Medicine, Vol 9 (2022)
Externí odkaz:
https://doaj.org/article/6501df818e524d8882cb7aadb9ab9ca9
Publikováno v:
Frontiers in Cardiovascular Medicine, Vol 9 (2022)
Externí odkaz:
https://doaj.org/article/13feed3406924a398fc6c6cad56c88e7
Autor:
Oriol Iborra-Egea, MSc, Evelyn Santiago-Vacas, MD, Salva R. Yurista, MD, Josep Lupón, MD, PhD, Milton Packer, MD, Stephane Heymans, MD, Faiez Zannad, MD, Javed Butler, MD, Domingo Pascual-Figal, MD, Antonio Lax, PhD, Julio Núñez, MD, PhD, Rudolf A. de Boer, MD, PhD, Antoni Bayés-Genís, MD, PhD
Publikováno v:
JACC: Basic to Translational Science, Vol 4, Iss 7, Pp 831-840 (2019)
Summary: The mechanism of action of empagliflozin in heart failure with reduced ejection fraction (HFrEF) was deciphered using deep learning in silico analyses together with in vivo validation. The most robust mechanism of action involved the sodium-
Externí odkaz:
https://doaj.org/article/13afc25ce0834e1783d290a10c5de95e
Autor:
Isaac Perea-Gil, Carolina Gálvez-Montón, Cristina Prat-Vidal, Ignasi Jorba, Cristina Segú-Vergés, Santiago Roura, Carolina Soler-Botija, Oriol Iborra-Egea, Elena Revuelta-López, Marco A. Fernández, Ramon Farré, Daniel Navajas, Antoni Bayes-Genis
Publikováno v:
Scientific Reports, Vol 8, Iss 1, Pp 1-13 (2018)
Abstract Cardiac tissue engineering, which combines cells and supportive scaffolds, is an emerging treatment for restoring cardiac function after myocardial infarction (MI), although, the optimal construct remains a challenge. We developed two engine
Externí odkaz:
https://doaj.org/article/4ce7e5a2aff842ad94cdf5df21a4e19d
Publikováno v:
Biomedicines, Vol 9, Iss 12, p 1836 (2021)
Myocardial infarction is the main driver of heart failure due to ischemia and subsequent cell death, and cell-based strategies have emerged as promising therapeutic methods to replace dead tissue in cardiovascular diseases. Research in this field has
Externí odkaz:
https://doaj.org/article/cd93a4d0a1b84ddfba5bdb6b1e7653df
Autor:
Oriol Iborra-Egea, Carolina Gálvez-Montón, Cristina Prat-Vidal, Santiago Roura, Carolina Soler-Botija, Elena Revuelta-López, Gemma Ferrer-Curriu, Cristina Segú-Vergés, Araceli Mellado-Bergillos, Pol Gomez-Puchades, Paloma Gastelurrutia, Antoni Bayes-Genis
Publikováno v:
Cells, Vol 10, Iss 12, p 3268 (2021)
Specific proteins and processes have been identified in post-myocardial infarction (MI) pathological remodeling, but a comprehensive understanding of the complete molecular evolution is lacking. We generated microarray data from swine heart biopsies
Externí odkaz:
https://doaj.org/article/d53d773785f54a7da75c6b9a1c5e0001
Autor:
Oriol Iborra-Egea, Carolina Gálvez-Montón, Santiago Roura, Isaac Perea-Gil, Cristina Prat-Vidal, Carolina Soler-Botija, Antoni Bayes-Genis
Publikováno v:
npj Systems Biology and Applications, Vol 3, Iss 1, Pp 1-9 (2017)
Cardiology: Heart Failure Medication Reduces Heart Size The new wonder drug in heart failure management, Sacubitril/Valsartan, rejuvenates the heart by preventing its dilation. Using data from myocardial infarction and heart failure samples, we gener
Externí odkaz:
https://doaj.org/article/1dc9147ff92843cb906f2df012fb2dc5