Zobrazeno 1 - 10
of 49
pro vyhledávání: '"Oriol Canela‐Xandri"'
Autor:
Ana Villaplana-Velasco, Marie Pigeyre, Justin Engelmann, Konrad Rawlik, Oriol Canela-Xandri, Claire Tochel, Frida Lona-Durazo, Muthu Rama Krishnan Mookiah, Alex Doney, Esteban J. Parra, Emanuele Trucco, Tom MacGillivray, Kristiina Rannikmae, Albert Tenesa, Erola Pairo-Castineira, Miguel O. Bernabeu
Publikováno v:
Communications Biology, Vol 6, Iss 1, Pp 1-13 (2023)
Abstract There is increasing evidence that the complexity of the retinal vasculature measured as fractal dimension, Df, might offer earlier insights into the progression of coronary artery disease (CAD) before traditional biomarkers can be detected.
Externí odkaz:
https://doaj.org/article/9575d863a72646d1847fcdfd16c30071
Autor:
Yuelin Yao, Shuli Liu, Charley Xia, Yahui Gao, Zhangyuan Pan, Oriol Canela-Xandri, Ava Khamseh, Konrad Rawlik, Sheng Wang, Bingjie Li, Yi Zhang, Erola Pairo-Castineira, Kenton D’Mellow, Xiujin Li, Ze Yan, Cong-jun Li, Ying Yu, Shengli Zhang, Li Ma, John B. Cole, Pablo J. Ross, Huaijun Zhou, Chris Haley, George E. Liu, Lingzhao Fang, Albert Tenesa
Publikováno v:
Genome Biology, Vol 23, Iss 1, Pp 1-24 (2022)
Abstract Background Cross-species comparison of transcriptomes is important for elucidating evolutionary molecular mechanisms underpinning phenotypic variation between and within species, yet to date it has been essentially limited to model organisms
Externí odkaz:
https://doaj.org/article/8e63f5a62bc44afea9ce80f059475d95
Autor:
Yanni Zeng, Carmen Amador, Charley Xia, Riccardo Marioni, Duncan Sproul, Rosie M. Walker, Stewart W. Morris, Andrew Bretherick, Oriol Canela-Xandri, Thibaud S. Boutin, David W. Clark, Archie Campbell, Konrad Rawlik, Caroline Hayward, Reka Nagy, Albert Tenesa, David J. Porteous, James F. Wilson, Ian J. Deary, Kathryn L. Evans, Andrew M. McIntosh, Pau Navarro, Chris S. Haley
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-13 (2019)
Parent-of-origin effects (POE) are observed when there are different effects from alleles inherited from the two parents on phenotypic measures. Here, Zeng et al. study POE on DNA methylation in 5,101 individuals and identify genetic variants that as
Externí odkaz:
https://doaj.org/article/13fb59ef0899422fa835edb1cbd7b338
Autor:
Andrew D Bretherick, Oriol Canela-Xandri, Peter K Joshi, David W Clark, Konrad Rawlik, Thibaud S Boutin, Yanni Zeng, Carmen Amador, Pau Navarro, Igor Rudan, Alan F Wright, Harry Campbell, Veronique Vitart, Caroline Hayward, James F Wilson, Albert Tenesa, Chris P Ponting, J Kenneth Baillie, Chris Haley
Publikováno v:
PLoS Genetics, Vol 16, Iss 7, p e1008785 (2020)
To efficiently transform genetic associations into drug targets requires evidence that a particular gene, and its encoded protein, contribute causally to a disease. To achieve this, we employ a three-step proteome-by-phenome Mendelian Randomization (
Externí odkaz:
https://doaj.org/article/4343fcaa019c4dbfb203fe430fdf7716
Autor:
Yabo Li, Hyosuk Cho, Fan Wang, Oriol Canela‐Xandri, Chunyan Luo, Konrad Rawlik, Stephen Archacki, Chengqi Xu, Albert Tenesa, Qiuyun Chen, Qing Kenneth Wang
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 9, Iss 7 (2020)
Background Epistasis describes how gene‐gene interactions affect phenotypes, and could have a profound impact on human diseases such as coronary artery disease (CAD). The goal of this study was to identify gene‐gene interactions in CAD using an e
Externí odkaz:
https://doaj.org/article/0a3445cba489428884a3a35fe867f338
Autor:
Michael D. Morgan, Erola Pairo-Castineira, Konrad Rawlik, Oriol Canela-Xandri, Jonathan Rees, David Sims, Albert Tenesa, Ian J. Jackson
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-10 (2018)
Natural hair colour in Europeans is a complex genetic trait. Here, the authors carry out a genome-wide association study using UK BioBank data, suggesting that in combination with pigmentation genes, variants with roles in hair texture and growth can
Externí odkaz:
https://doaj.org/article/2eba2885b80d406faeefb9db26b685e9
Autor:
Yanni Zeng, Carmen Amador, Charley Xia, Riccardo Marioni, Duncan Sproul, Rosie M. Walker, Stewart W. Morris, Andrew Bretherick, Oriol Canela-Xandri, Thibaud S. Boutin, David W. Clark, Archie Campbell, Konrad Rawlik, Caroline Hayward, Reka Nagy, Albert Tenesa, David J. Porteous, James F. Wilson, Ian J. Deary, Kathryn L. Evans, Andrew M. McIntosh, Pau Navarro, Chris S. Haley
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-1 (2019)
In the original version of this Article, the legend in the upper panel of Figure 2 incorrectly read ‘paternal imprinting’ and should have read ‘maternal imprinting’. This has been corrected in both the PDF and HTML versions of the Article.
Externí odkaz:
https://doaj.org/article/f4158d8099fd4274ae3e94b11a18b725
Publikováno v:
PLoS ONE, Vol 11, Iss 12, p e0166755 (2016)
Genome-wide association studies (GWAS) promised to translate their findings into clinically beneficial improvements of patient management by tailoring disease management to the individual through the prediction of disease risk. However, the ability t
Externí odkaz:
https://doaj.org/article/35ddc098f2484824bdfc8ae3c1eb2c89
Publikováno v:
PLoS ONE, Vol 8, Iss 7, p e68822 (2013)
We present GStream, a method that combines genome-wide SNP and CNV genotyping in the Illumina microarray platform with unprecedented accuracy. This new method outperforms previous well-established SNP genotyping software. More importantly, the CNV ca
Externí odkaz:
https://doaj.org/article/9dbd18cc94cd433ba46d9d3ce5b6b887
Publikováno v:
PLoS Computational Biology, Vol 7, Iss 9, p e1002153 (2011)
Shaping the primordia during development relies on forces and mechanisms able to control cell segregation. In the imaginal discs of Drosophila the cellular populations that will give rise to the dorsal and ventral parts on the wing blade are segregat
Externí odkaz:
https://doaj.org/article/c4f29f69d95245889473ff1022b860aa