Zobrazeno 1 - 10
of 60
pro vyhledávání: '"Orina Isaac A"'
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 18, Iss 4, p e0012103 (2024)
BackgroundThe severe late stage Human African Trypanosomiasis (HAT) caused by Trypanosoma brucei rhodesiense (T.b.r) is characterized by damage to the blood brain barrier, severe brain inflammation, oxidative stress and organ damage. Melarsoprol (Mel
Externí odkaz:
https://doaj.org/article/0d9c6544773148b880cdc8ca93a2227c
Autor:
Pherah A. Ouma, Victoria K. Mwaeni, Peris W. Amwayi, Alfred Orina Isaac, James Nyabuga Nyariki
Publikováno v:
Laboratory Animal Research, Vol 38, Iss 1, Pp 1-16 (2022)
Abstract Background Calcium carbide (CaC2) is a chemical primarily used in the production of acetylene gas. The misuse of CaC2 to induce fruit ripening is a global challenge with a potential adverse effects to human health. Additionally, CaC2 is know
Externí odkaz:
https://doaj.org/article/292d10c893584335903654307e494570
Autor:
Nancy S. Mitalo, Naomi N. Waiganjo, John Mokua Mose, David O. Bosire, James O. Oula, Alfred Orina Isaac, James Nyabuga Nyariki
Publikováno v:
Journal of Tropical Medicine, Vol 2023 (2023)
Introduction. Human African trypanosomiasis (HAT) and schistosomiasis are neglected parasitic diseases found in the African continent. This study was conducted to determine how primary infection with Schistosoma mansoni affects HAT disease progressio
Externí odkaz:
https://doaj.org/article/1ba85cc7763344e9b87c43c0f33dcfb2
Autor:
Nancy Wambui Wairimu, Peninah Wairagu, Kennedy W. Chepukosi, George F. Obiero, Patrick W. Okanya, Alfred Orina Isaac, James Nyabuga Nyariki
Publikováno v:
Journal of Toxicology, Vol 2023 (2023)
Sodium metabisulfite (SMB) is a biocide and antioxidant agent generally used as a preservative in food and beverage industries but can oxidize to harmful sulfite radicals. A standardized Ginkgo biloba (EGb-761) has demonstrated potent antioxidant and
Externí odkaz:
https://doaj.org/article/c703270227554d93a2af16714031f50d
Autor:
Victoria K. Mwaeni, James N. Nyariki, Ngalla Jillani, George Omwenga, Mathew Ngugi, Alfred Orina Isaac
Publikováno v:
BMC Pharmacology and Toxicology, Vol 22, Iss 1, Pp 1-19 (2021)
Abstract Background Arsenic poisoning affects millions of people. The inorganic forms of arsenic are more toxic. Treatment for arsenic poisoning relies on chelation of extracellularly circulating arsenic molecules by 2,3-dimecaptosuccinic acid (DMSA)
Externí odkaz:
https://doaj.org/article/9bad91049757416bbce679c7f444b813
Autor:
Francis Gitonga, Kipchumba Biwott, Grace Wairimu Gitau, Okanya Patrick Wafula, Peris Amwayi, Alfred Orina Isaac, James Nyabuga Nyariki
Publikováno v:
Scientific African, Vol 12, Iss , Pp e00815- (2021)
Potassium cyanide (KCN) is one of the most lethal and feared poison; which devastates cellular respiration resulting in death due to hypoxia. Several antidotes exist, but most face major limitations of safety and efficacy. Moreover, there is a need f
Externí odkaz:
https://doaj.org/article/be5c42235a72450b8a68bac493b909a1
Autor:
Mitalo, Nancy S., Waiganjo, Naomi N., Mokua Mose, John, Bosire, David O., Oula, James O., Orina Isaac, Alfred, Nyabuga Nyariki, James
Publikováno v:
Journal of Tropical Medicine (16879686); 11/3/2023, p1-16, 16p
Coenzyme Q10 nullified khat-induced hepatotoxicity, nephrotoxicity and inflammation in a mouse model
Autor:
Chepukosi Kennedy, Patrick Okanya, James Nyabuga Nyariki, Peris Amwayi, Ngalla Jillani, Alfred Orina Isaac
Publikováno v:
Heliyon, Vol 6, Iss 9, Pp e04917- (2020)
Ethnopharmacological relevance: The consumption of khat (Catha Edulis, Forsk) is on the rise despite the much publicized associated deleterious health effects. How chemicals present in khat, affect various physiological and biochemical processes requ
Externí odkaz:
https://doaj.org/article/91379ba273ff49ab803079e14ec6ac08
Autor:
Lynn Kitwan, Celestine Makobe, Raymond Mdachi, Dawn Nyawira Maranga, Alfred Orina Isaac, James Nyabuga Nyariki
Publikováno v:
Journal of Parasitic Diseases. 47:167-184
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::452a6477c4c0ed941eefe4b7fa0a8448
https://doi.org/10.1007/s12639-022-01553-8
https://doi.org/10.1007/s12639-022-01553-8
Autor:
David B. Ouko, Peris W. Amwayi, Lucy A. Ochola, Peninah M. Wairagu, Alfred Orina Isaac, James N. Nyariki
Publikováno v:
J Parasit Dis
Development of cerebral malaria (CM) is driven by parasitemia levels, harmful inflammatory response, oxidative stress and consequent breach of the blood brain barrier. Use of adjunct therapy that utilizes an antioxidant and anti-inflammatory agent al
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3bf26f1102e006bb78288d3ac9443a38
https://doi.org/10.1007/s12639-022-01468-4
https://doi.org/10.1007/s12639-022-01468-4