Zobrazeno 1 - 10
of 167
pro vyhledávání: '"Orin Bloch"'
Publikováno v:
F1000Research, Vol 13 (2024)
Background Glioblastoma (GBM) is a clinically challenging primary brain tumor with poor survival outcome despite surgical resection and intensive chemoradiation. The metabolic heterogeneity of GBM can become biomarkers for treatment response, resista
Externí odkaz:
https://doaj.org/article/a0203848f90049648c4cd889f913fd83
Autor:
Orwa Aboud, Yin Liu, Lina Dahabiyeh, Ahmad Abuaisheh, Fangzhou Li, John Paul Aboubechara, Jonathan Riess, Orin Bloch, Rawad Hodeify, Ilias Tagkopoulos, Oliver Fiehn
Publikováno v:
Biomedicines, Vol 11, Iss 8, p 2261 (2023)
Introduction: Biogenic amines play important roles throughout cellular metabolism. This study explores a role of biogenic amines in glioblastoma pathogenesis. Here, we characterize the plasma levels of biogenic amines in glioblastoma patients undergo
Externí odkaz:
https://doaj.org/article/06b46893d7a04aa082649948f42e7f1e
Autor:
Orwa Aboud, Yin Allison Liu, Oliver Fiehn, Christopher Brydges, Ruben Fragoso, Han Sung Lee, Jonathan Riess, Rawad Hodeify, Orin Bloch
Publikováno v:
Metabolites, Vol 13, Iss 2, p 299 (2023)
We here characterize changes in metabolite patterns in glioblastoma patients undergoing surgery and concurrent chemoradiation using machine learning (ML) algorithms to characterize metabolic changes during different stages of the treatment protocol.
Externí odkaz:
https://doaj.org/article/e1acb50fdeac4afa8f8abc0d314b2195
Autor:
Joseph DiDomenico, Jonathan B. Lamano, Daniel Oyon, Yuping Li, Dorina Veliceasa, Gurvinder Kaur, Leonel Ampie, Winward Choy, Jason B. Lamano, Orin Bloch
Publikováno v:
OncoImmunology, Vol 7, Iss 7 (2018)
Glioblastoma (GBM) promotes immunosuppression through upregulation of PD-L1 and regulatory T cell (Treg) expansion, but the association of these suppressive factors has not been well elucidated. Here, we investigate a role of PD-L1 in expanding Tregs
Externí odkaz:
https://doaj.org/article/06dc450007ca42b591d12e9bb439a8ab
Autor:
Michael Safaee, Shayan Fakurnejad, Orin Bloch, Aaron J Clark, Michael E Ivan, Matthew Z Sun, Taemin Oh, Joanna J Phillips, Andrew T Parsa
Publikováno v:
PLoS ONE, Vol 10, Iss 2, p e0111532 (2015)
CD97 is a novel glioma antigen that confers an invasive phenotype and poor survival in patients with glioblastoma (GBM), the most aggressive primary malignant brain tumor. The short isoform of CD97, known as EGF(1,2,5), has been shown to promote inva
Externí odkaz:
https://doaj.org/article/7005aecdcdee44da900acb36a3cdf89c
Autor:
Eli T. Sayegh, Grant A. Henderson, Ezra A. Burch, Gerald F. Reis, Soonmee Cha, Taemin Oh, Orin Bloch, Andrew T. Parsa
Publikováno v:
Rare Tumors, Vol 6, Iss 2 (2014)
Tumor-to-tumor metastasis of breast carcinoma to meningioma is a rare phenomenon. It is likely underdiagnosed given the relatively high prevalence and comorbidity of these two primary tumor types, the lack of standardized methodologies for its diagno
Externí odkaz:
https://doaj.org/article/638f59f7be7a45b199137a75e173f4ec
Autor:
Michael Safaee, Michael E. Ivan, Michael C. Oh, Taemin Oh, Eli T. Sayegh, Gurvinder Kaur, Matthew Z. Sun, Orin Bloch, Andrew T. Parsa
Publikováno v:
Oncology Reviews, Vol 8, Iss 1 (2014)
G-protein coupled receptors (GPCRs) are among the most diverse and ubiquitous proteins in all of biology. The epidermal growth factorseven span transmembrane (EGF-TM7) subfamily of adhesion GPCRs is a small subset whose members are mainly expressed o
Externí odkaz:
https://doaj.org/article/ba98250b93534be4bbb262ce4f670603
Autor:
Michael Safaee, Aaron J Clark, Michael C Oh, Michael E Ivan, Orin Bloch, Gurvinder Kaur, Matthew Z Sun, Joseph M Kim, Taemin Oh, Mitchel S Berger, Andrew T Parsa
Publikováno v:
PLoS ONE, Vol 8, Iss 4, p e62765 (2013)
Mechanisms of invasion in glioblastoma (GBM) relate to differential expression of proteins conferring increased motility and penetration of the extracellular matrix. CD97 is a member of the epidermal growth factor seven-span transmembrane family of a
Externí odkaz:
https://doaj.org/article/179eb5e4f52346e08c2a11eded459f96
Autor:
Craig Horbinski, Louis Burt Nabors, Jana Portnow, Joachim Baehring, Ankush Bhatia, Orin Bloch, Steven Brem, Nicholas Butowski, Donald M. Cannon, Samuel Chao, Milan G. Chheda, Andrew J. Fabiano, Peter Forsyth, Pierre Gigilio, Jona Hattangadi-Gluth, Matthias Holdhoff, Larry Junck, Thomas Kaley, Ryan Merrell, Maciej M. Mrugala, Seema Nagpal, Lucien A. Nedzi, Kathryn Nevel, Phioanh L. Nghiemphu, Ian Parney, Toral R. Patel, Katherine Peters, Vinay K. Puduvalli, Jason Rockhill, Chad Rusthoven, Nicole Shonka, Lode J. Swinnen, Stephanie Weiss, Patrick Yung Wen, Nicole E. Willmarth, Mary Anne Bergman, Susan Darlow
Publikováno v:
Journal of the National Comprehensive Cancer Network. 21:12-20
The NCCN Guidelines for Central Nervous System (CNS) Cancers focus on management of the following adult CNS cancers: glioma (WHO grade 1, WHO grade 2–3 oligodendroglioma [1p19q codeleted, IDH-mutant], WHO grade 2–4 IDH-mutant astrocytoma, WHO gra
Autor:
Michael T Sharp, Orin Bloch, Jonathan B. Lamano, Dennis Lee, Robert A. Riestenberg, Aden P. Haskell-Mendoza
Publikováno v:
Journal of Neurosurgery. 136:1760-1772
OBJECTIVE Patients increasingly utilize online physician review websites (PRWs) and social media to inform healthcare-related decisions. This provides neurosurgeons with opportunities for increased patient engagement. And despite the growing use of s