Zobrazeno 1 - 10
of 36
pro vyhledávání: '"Origin selection"'
Autor:
Bik-Kwoon Tye, Yuanliang Zhai
Publikováno v:
Biology, Vol 13, Iss 1, p 13 (2023)
Understanding human DNA replication through the study of yeast has been an extremely fruitful journey. The minichromosome maintenance (MCM) 2–7 genes that encode the catalytic core of the eukaryotic replisome were initially identified through forwa
Externí odkaz:
https://doaj.org/article/bee22c1d798f4d7a90571c1add4367d4
Akademický článek
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Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
Nature Communications
Nature Communications
Hexameric helicases are motor proteins that unwind double-stranded DNA (dsDNA) during DNA replication but how they are optimised for strand separation is unclear. Here we present the cryo-EM structure of the full-length E1 helicase from papillomaviru
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::76e77749004418d7d8d0208d971e85e0
https://doaj.org/article/32ab17c170964352825d558a35b79273
https://doaj.org/article/32ab17c170964352825d558a35b79273
Publikováno v:
Journal of the Serbian Chemical Society, Vol 75, Iss 3, Pp 317-322 (2010)
Human origin recognition complex 4 (ORC4) protein, a subunit of the origin recognition complex, belongs to the AAA+ superfamily of adenosine triphosphate (ATP) ases. Proteins belonging to this family require ATP for their function and interactions wi
Externí odkaz:
https://doaj.org/article/3fc8702c481947baaa008a1be6fa97c7
Publikováno v:
Scientific Reports
Scientific Reports, Vol 11, Iss 1, Pp 1-14 (2021)
Scientific Reports, Vol 11, Iss 1, Pp 1-14 (2021)
Suppressor of Hairy wing [Su(Hw)] is an insulator protein that participates in regulating chromatin architecture and gene repression in Drosophila. In previous studies we have shown that Su(Hw) is also required for pre-replication complex (pre-RC) re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3499422e1fb161c2a142460d0092ccf3
https://doi.org/10.1038/s41598-021-96488-0
https://doi.org/10.1038/s41598-021-96488-0
Autor:
Jacob M. Gross, Sang-Min Jang, Christophe E. Redon, Sophie Z. Zhuang, Anna B. Marks, Lorinc Pongor, Mirit I. Aladjem, Shira T. Mencer, Koichi Utani, Adrian Baris, Sarah B. Lazar, Bhushan Thakur, Mishal Rao, Haiqing Fu, Sara Mosavarpour, Robin Sebastian
Publikováno v:
Nature Communications
Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
Safeguards against excess DNA replication are often dysregulated in cancer, and driving cancer cells towards over-replication is a promising therapeutic strategy. We determined DNA synthesis patterns in cancer cells undergoing partial genome re-repli
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5e03f4eb71272bd71e648afee2c56961
http://europepmc.org/articles/PMC8187443
http://europepmc.org/articles/PMC8187443
Autor:
Humberto Sanchez, Edo van Veen, Nynke H. Dekker, Kaley McCluskey, John F.X. Diffley, Belen Solano, Theo van Laar, Filip M. Asscher
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
Nature Communications, 12(1)
Nature Communications
Nature Communications, 12(1)
Nature Communications
DNA replication in eukaryotes initiates at many origins distributed across each chromosome. Origins are bound by the origin recognition complex (ORC), which, with Cdc6 and Cdt1, recruits and loads the Mcm2-7 (MCM) helicase as an inactive double hexam
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::73f695ca7335830846d7a954f0600e73
https://doi.org/10.1038/s41467-021-22216-x
https://doi.org/10.1038/s41467-021-22216-x
Publikováno v:
Cell Discovery
The function of the origin recognition complex (ORC) in DNA replication is highly conserved in recognizing and marking the initiation sites. The detailed molecular mechanisms by which human ORC is reconfigured into a state competent for origin associ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c76180dfa1baa927f0b23d77d21a08d3
http://europepmc.org/articles/PMC7684300
http://europepmc.org/articles/PMC7684300
Autor:
Ammar Tareen, Bruce Stillman, Huilin Li, Christian Speck, William T. Ireland, Yi-Jun Sheu, Yixin Hu, Leemor Joshua-Tor, Justin B. Kinney
Publikováno v:
Nature Communications
Nature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
Nature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
DNA replication in eukaryotic cells initiates from replication origins that bind the Origin Recognition Complex (ORC). Origin establishment requires well-defined DNA sequence motifs in Saccharomyces cerevisiae and some other budding yeasts, but most
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a93f3394324e2d60f66a92c50013ed5
https://pubmed.ncbi.nlm.nih.gov/33056978
https://pubmed.ncbi.nlm.nih.gov/33056978
Autor:
Marion Blin, Caroline Brossas, Gaël A. Millot, Mélanie Schmidt, Viola Nähse, Marie-Noëlle Prioleau, Michelle Debatisse, Benoît Le Tallec
Publikováno v:
Nature Structural and Molecular Biology
Nature Structural and Molecular Biology, Nature Publishing Group, 2019, 26 (1), pp.58-66. ⟨10.1038/s41594-018-0170-1⟩
Nature Structural and Molecular Biology, 2019, 26 (1), pp.58-66. ⟨10.1038/s41594-018-0170-1⟩
Nature Structural and Molecular Biology, Nature Publishing Group, 2019, 26 (1), pp.58-66. ⟨10.1038/s41594-018-0170-1⟩
Nature Structural and Molecular Biology, 2019, 26 (1), pp.58-66. ⟨10.1038/s41594-018-0170-1⟩
International audience; Common fragile sites (CFSs) are loci that are hypersensitive to replication stress and hotspots for chromosomal rearrangements in cancers. CFSs replicate late in S phase, are cell-type specific and nest in large genes. The rel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::43eeaf52d0908fdafd2f3542152ba98e
https://doi.org/10.1038/s41594-018-0170-1
https://doi.org/10.1038/s41594-018-0170-1