Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Origène Nyanguile"'
Autor:
Marc Mathieu, Origène Nyanguile
Publikováno v:
CHIMIA, Vol 75, Iss 6, Pp 539-542 (2021)
The new Energypolis campus brings together the skills of EPFL Valais-Wallis, HES-SO Valais-Wallis, and the Ark Foundation's services. Together these partners respond to today's major concerns in the domains of energy, health, and the environment cutt
Externí odkaz:
https://doaj.org/article/f4a80935290b44a4a6221598b4c02198
Autor:
Origène Nyanguile
Publikováno v:
Frontiers in Immunology, Vol 10 (2019)
Lower respiratory infection caused by human pathogens such as influenza and respiratory syncytial virus (RSV) is a significant healthcare burden that must be addressed. The preferred options to achieve this goal are usually to develop vaccines for pr
Externí odkaz:
https://doaj.org/article/2490d8f1599749a0aeffff625a0de9ac
Autor:
Viktoriia Postupalenko, Léo Marx, David Viertl, Nadège Gsponer, Natalia Gasilova, Thibaut Denoel, Niklaus Schaefer, John O. Prior, Gerrit Hagens, Frédéric Lévy, Patrick Garrouste, Jean-Manuel Segura, Origène Nyanguile
Publikováno v:
Chemical science, vol. 13, no. 14, pp. 3965-3976
Antibodies are an attractive therapeutic modality for cancer treatment as they allow the increase of the treatment response rate and avoid the severe side effects of chemotherapy. Notwithstanding the strong benefit of antibodies, the efficacy of anti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::35be75d9779d7e6413019342ceae51e9
https://pubmed.ncbi.nlm.nih.gov/35440989
https://pubmed.ncbi.nlm.nih.gov/35440989
Autor:
Ronan Le Goffic, Vanessa Gaillard, Julie Rivière, Joelle Mettier, Charles-Adrien Richard, Origène Nyanguile, Nadege Gsponer, Thibaut Larcher, Brice Fenner, Marthe Vilotte, Marie Galloux, Jean-François Eléouët
Publikováno v:
Antimicrobial Agents and Chemotherapy
Antimicrobial Agents and Chemotherapy, American Society for Microbiology, 2020, 64 (10), ⟨10.1128/AAC.00717-20⟩
Antimicrobial Agents and Chemotherapy, American Society for Microbiology, 2020, 64 (10), ⟨10.1128/AAC.00717-20⟩
Respiratory syncytial virus (RSV) is the main cause of severe respiratory infection in young children worldwide, and no therapies have been approved for the treatment of RSV infection. Data from recent clinical trials of fusion or L polymerase inhibi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d67b5f7e77f629ffadf729632b3b3d1d
https://hal.inrae.fr/hal-03353101/document
https://hal.inrae.fr/hal-03353101/document
Autor:
Marie, Galloux, Nadège, Gsponer, Vanessa, Gaillard, Brice, Fenner, Thibaut, Larcher, Marthe, Vilotte, Julie, Rivière, Charles-Adrien, Richard, Jean-François, Eléouët, Ronan, Le Goffic, Joelle, Mettier, Origène, Nyanguile
Publikováno v:
Antimicrobial agents and chemotherapy. 64(10)
Respiratory syncytial virus (RSV) is the main cause of severe respiratory infection in young children worldwide, and no therapies have been approved for the treatment of RSV infection. Data from recent clinical trials of fusion or L polymerase inhibi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::407476314c208f090a271822eb2888f5
https://pubmed.ncbi.nlm.nih.gov/32660994
https://pubmed.ncbi.nlm.nih.gov/32660994
Autor:
Geneviève Mottet-Osman, Origène Nyanguile, Elodie Baechler, Miriam Arrell, Abdelhak Boukadiri, Ronan Le Goffic, Marie Galloux, Julien Héritier, Thibaut Larcher, Marie-Anne Rameix-Welti, Jean-Manuel Segura, Vanessa Gaillard, Dominique Garcin, Jean-François Eléouët
Publikováno v:
Antimicrobial Agents and Chemotherapy
Antimicrobial Agents and Chemotherapy, American Society for Microbiology, 2017, 61 (4), ⟨10.1128/AAC.02241-16⟩
Antimicrobial Agents and Chemotherapy, Vol. 61, No 4 (2017)
Antimicrobial Agents and Chemotherapy 4 (61), . (2017)
Antimicrobial Agents and Chemotherapy, American Society for Microbiology, 2017, 61 (4), ⟨10.1128/AAC.02241-16⟩
Antimicrobial Agents and Chemotherapy, Vol. 61, No 4 (2017)
Antimicrobial Agents and Chemotherapy 4 (61), . (2017)
Synthetic peptides derived from the heptad repeat (HR) of fusion (F) proteins can be used as dominant negative inhibitors to inhibit the fusion mechanism of class I viral F proteins. Here, we have performed a stapled-peptide scan across the HR2 domai
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::42d9ab78830028b578b55da1df748637
https://hal.archives-ouvertes.fr/hal-01605887/file/2017_Gaillard_AntimicrobialAgentsAndChemotherapy_1.pdf
https://hal.archives-ouvertes.fr/hal-01605887/file/2017_Gaillard_AntimicrobialAgentsAndChemotherapy_1.pdf
Autor:
Maxwell D. Cummings, Tse-I Lin, Lili Hu, Abdellah Tahri, David McGowan, Katie Amssoms, Stefaan Last, Benoit Devogelaere, Marie-Claude Rouan, Leen Vijgen, Jan Martin Berke, Pascale Dehertogh, Els Fransen, Erna Cleiren, Liesbet van der Helm, Gregory Fanning, Origène Nyanguile, Kenny Simmen, Pieter Van Remoortere, Pierre Raboisson, Sandrine Vendeville
Publikováno v:
Journal of Medicinal Chemistry. 57:1880-1892
Structure-based macrocyclization of a 6-carboxylic acid indole chemotype has yielded potent and selective finger-loop inhibitors of the hepatitis C virus (HCV) NS5B polymerase. Lead optimization in conjunction with in vivo evaluation in rats identifi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a739d81f60a1fc5d33b63d73ddc9a32b
https://doi.org/10.1021/jm401396p
https://doi.org/10.1021/jm401396p
Autor:
Liesbet van der Helm, Kenneth Simmen, Origène Nyanguile, Reginald F. Clayton, Tse I. Lin, Pascale Dehertogh, Gregory Fanning, Leen Vijgen, Oliver Lenz, Els Fransen, Pierre Jean-Marie Bernard Raboisson, Benoit Devogelaere, Sandrine Vendeville, Erna Cleiren, Katie Amssoms, Maxwell D. Cummings, Abdellah Tahri, Jan Martin Berke
Publikováno v:
Antimicrobial Agents and Chemotherapy. 56:4676-4684
Hepatitis C virus (HCV) infection is a major global health burden and is associated with an increased risk of liver cirrhosis and hepatocellular carcinoma. There remains an unmet medical need for efficacious and safe direct antivirals with complement
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5a8dee5d8bfd6f25c3bfb9a920a7ef6d
https://doi.org/10.1128/aac.00245-12
https://doi.org/10.1128/aac.00245-12
Autor:
Sandrine Vendeville, Tse-I. Lin, Lili Hu, Abdellah Tahri, David McGowan, Maxwell D. Cummings, Katie Amssoms, Maxime Canard, Stefaan Last, Iris Van den Steen, Benoit Devogelaere, Marie-Claude Rouan, Leen Vijgen, Jan Martin Berke, Pascale Dehertogh, Els Fransen, Erna Cleiren, Liesbet van der Helm, Gregory Fanning, Kristof Van Emelen, Origène Nyanguile, Kenny Simmen, Pierre Raboisson
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 22:4437-4443
Optimization of a novel series of macrocyclic indole-based inhibitors of the HCV NS5b polymerase targeting the finger loop domain led to the discovery of lead compounds exhibiting improved potency in cellular assays and superior pharmacokinetic profi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dbdda9d43e14137e73732d76cab0062d
https://doi.org/10.1016/j.bmcl.2012.04.113
https://doi.org/10.1016/j.bmcl.2012.04.113
Autor:
Geneviève Vandercruyssen, Origène Nyanguile, Leen Vijgen, Frederik Pauwels, Pascale Dehertogh, Koen Dockx, Hendrik L. De Bondt, Wendy Mostmans, Benoit Devogelaere, Gregory Fanning, Vendeville Sandrine Marie Hele, Pierre Raboisson, Oliver Lenz, Frederic Delouvroy, Ann Vos, Koen Vandyck, Katrien Vermeiren, Erna Cleiren, Walter Van den Broeck, Jan Martin Berke, Kenneth Simmen, Maxwell D. Cummings
Publikováno v:
Journal of Virology. 84:2923-2934
The RNA-dependent RNA polymerase (NS5B) of hepatitis C virus (HCV) is an unusually attractive target for drug discovery since it contains five distinct drugable sites. The success of novel antiviral therapies will require nonnucleoside inhibitors to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dc7fe42c112a586f3f503effe1181796
https://doi.org/10.1128/jvi.01980-09
https://doi.org/10.1128/jvi.01980-09