Zobrazeno 1 - 10
of 165
pro vyhledávání: '"Oriana, Tabarrini"'
Publikováno v:
Molecules, Vol 28, Iss 15, p 5849 (2023)
The identification of new targets to address unmet medical needs, better in a personalized way, is an urgent necessity. The introduction of PARP1 inhibitors into therapy, almost ten years ago, has represented a step forward this need being an innovat
Externí odkaz:
https://doaj.org/article/936737ab077e4bdd899a77f8e75804f3
Autor:
Tommaso Felicetti, Gianmarco Mangiaterra, Rolando Cannalire, Nicholas Cedraro, Donatella Pietrella, Andrea Astolfi, Serena Massari, Oriana Tabarrini, Giuseppe Manfroni, Maria Letizia Barreca, Violetta Cecchetti, Francesca Biavasco, Stefano Sabatini
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 35, Iss 1, Pp 584-597 (2020)
NorA is the most studied efflux pump of Staphylococcus aureus and is responsible for high level resistance towards fluoroquinolone drugs. Although along the years many NorA efflux pump inhibitors (EPIs) have been reported, poor information is availab
Externí odkaz:
https://doaj.org/article/5d409e0254d546e4bebeb4a36d0593e8
Autor:
Andrea Astolfi, Francesca Milano, Deborah Palazzotti, Jose Brea, Maria Chiara Pismataro, Mariangela Morlando, Oriana Tabarrini, Maria Isabel Loza, Serena Massari, Maria Paola Martelli, Maria Letizia Barreca
Publikováno v:
Pharmaceutics, Vol 14, Iss 11, p 2295 (2022)
Acute myeloid leukemia (AML) is a heterogeneous hematopoietic malignancy whose prognosis is globally poor. In more than 60% of AML patients, the PI3K/AKTs/mTOR signaling pathway is aberrantly activated because of oncogenic driver alterations and furt
Externí odkaz:
https://doaj.org/article/2a4772fbd9da4f999fa09915db20c749
Autor:
Serena Massari, Angela Corona, Simona Distinto, Jenny Desantis, Alessia Caredda, Stefano Sabatini, Giuseppe Manfroni, Tommaso Felicetti, Violetta Cecchetti, Christophe Pannecouque, Elias Maccioni, Enzo Tramontano, Oriana Tabarrini
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 34, Iss 1, Pp 55-74 (2019)
The paper focussed on a step-by-step structural modification of a cycloheptathiophene-3-carboxamide derivative recently identified by us as reverse transcriptase (RT)-associated ribonuclease H (RNase H) inhibitor. In particular, its conversion to a 2
Externí odkaz:
https://doaj.org/article/b4e8f0c07ca642ccb28f0ad18fbcbe9c
Publikováno v:
Journal of Medicinal Chemistry. 65:7532-7560
Major advances have recently defined functions for human mono-ADP-ribosylating PARP enzymes (mono-ARTs), also opening up potential applications for targeting them to treat diseases. Structural biology combined with medicinal chemistry has allowed the
Autor:
Marco Gargaro, Carmine Vacca, Serena Massari, Giulia Scalisi, Giorgia Manni, Giada Mondanelli, Emilia M. C. Mazza, Silvio Bicciato, Maria T. Pallotta, Ciriana Orabona, Maria L. Belladonna, Claudia Volpi, Roberta Bianchi, Davide Matino, Alberta Iacono, Eleonora Panfili, Elisa Proietti, Ioana Maria Iamandii, Violetta Cecchetti, Paolo Puccetti, Oriana Tabarrini, Francesca Fallarino, Ursula Grohmann
Publikováno v:
Frontiers in Immunology, Vol 10 (2019)
Indoleamine 2,3-dioxygenase 1 (IDO1) catalyzes the first step in the kynurenine pathway of tryptophan (Trp) degradation that produces several biologically active Trp metabolites. L-kynurenine (Kyn), the first byproduct by IDO1, promotes immunoregulat
Externí odkaz:
https://doaj.org/article/032860991d8345e4af6022b45a22a771
Autor:
Sudarshan, Murthy, Maria Giulia, Nizi, Mirko M, Maksimainen, Serena, Massari, Juho, Alaviuhkola, Barbara E, Lippok, Chiara, Vagaggini, Sven T, Sowa, Albert, Galera-Prat, Yashwanth, Ashok, Harikanth, Venkannagari, Renata, Prunskaite-Hyyryläinen, Elena, Dreassi, Bernhard, Lüscher, Patricia, Korn, Oriana, Tabarrini, Lari, Lehtiö
Publikováno v:
Journal of medicinal chemistry.
We report [1,2,4]triazolo[3,4
Autor:
Sudarshan Murthy, Maria Giulia Nizi, Mirko M. Maksimainen, Serena Massari, Juho Alaviuhkola, Barbara E. Lippok, Chiara Vagaggini, Sven T. Sowa, Albert Galera-Prat, Yashwanth Ashok, Harikanth Venkannagari, Renata Prunskaite-Hyyryläinen, Elena Dreassi, Bernhard Lüscher, Patricia Korn, Oriana Tabarrini, Lari Lehtiö
Publikováno v:
Journal of medicinal chemistry 66(2), 1301-1320 (2023). doi:10.1021/acs.jmedchem.2c01460
Journal of medicinal chemistry 66(2), 1301-1320 (2023). doi:10.1021/acs.jmedchem.2c01460
Published by American Chemical Society, Washington, DC
Published by American Chemical Society, Washington, DC
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d02c78b88c3e04c15acc5405940609a1
http://urn.fi/urn:nbn:fi-fe2023032232837
http://urn.fi/urn:nbn:fi-fe2023032232837
Autor:
Rolando Cannalire, Gianmarco Mangiaterra, Tommaso Felicetti, Andrea Astolfi, Nicholas Cedraro, Serena Massari, Giuseppe Manfroni, Oriana Tabarrini, Salvatore Vaiasicca, Maria Letizia Barreca, Violetta Cecchetti, Francesca Biavasco, Stefano Sabatini
Publikováno v:
International Journal of Molecular Sciences, Vol 21, Iss 19, p 7037 (2020)
Tackling antimicrobial resistance (AMR) represents a social responsibility aimed at renewing the antimicrobial armamentarium and identifying novel therapeutical approaches. Among the possible strategies, efflux pumps inhibition offers the advantage t
Externí odkaz:
https://doaj.org/article/08be49557df64b43857ae72bb0206d4f
Autor:
Jenny Desantis, Serena Massari, Angela Corona, Andrea Astolfi, Stefano Sabatini, Giuseppe Manfroni, Deborah Palazzotti, Violetta Cecchetti, Christophe Pannecouque, Enzo Tramontano, Oriana Tabarrini
Publikováno v:
Molecules, Vol 25, Iss 5, p 1183 (2020)
Despite great efforts have been made in the prevention and therapy of human immunodeficiency virus (HIV-1) infection, however the difficulty to eradicate latent viral reservoirs together with the emergence of multi-drug-resistant strains require the
Externí odkaz:
https://doaj.org/article/eb2a061e05284ebf8e7d726841366e2a