Zobrazeno 1 - 10
of 25
pro vyhledávání: '"Ori Kalid"'
Autor:
Elena Campaner, Alessandra Rustighi, Alessandro Zannini, Alberto Cristiani, Silvano Piazza, Yari Ciani, Ori Kalid, Gali Golan, Erkan Baloglu, Sharon Shacham, Barbara Valsasina, Ulisse Cucchi, Agnese Chiara Pippione, Marco Lucio Lolli, Barbara Giabbai, Paola Storici, Paolo Carloni, Giulia Rossetti, Federica Benvenuti, Ezia Bello, Maurizio D’Incalci, Elisa Cappuzzello, Antonio Rosato, Giannino Del Sal
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-15 (2017)
PIN1 is a promising therapeutic target for cancer treatment. In this study, the authors identify a covalent inhibitor of PIN1 with anti-tumour and anti-metastatic properties thanks to PIN1 inactivation and to the release, after binding to PIN1, of a
Externí odkaz:
https://doaj.org/article/e607d20382804710bdbe82d915bc8ddd
Autor:
Ori, Kalid, Irina, Gotliv, Einat, Levy-Apter, Danit Finkelshtein, Beker, Marina, Cherniavsky-Lev, Etai, Rotem, Naama, Miron
Publikováno v:
Chemical Biology & Drug Design. 100:623-638
Cancer cells are dependent on protein quality-control mechanisms, including protein chaperones, the ubiquitin-proteasome system, and autophagy. The p62 receptor is a classical, ubiquitously expressed receptor, involved in many signal transduction pat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5292d7f7641c1e38474d84fe54660b08
https://doi.org/10.1111/cbdd.14046
https://doi.org/10.1111/cbdd.14046
Autor:
Daniel Zaidman, Ori Kalid, Idit Buch, Efrat Ben-Zeev, Tali Yarnizky, Itai Bloch, Idan Segev, Elad Segev, Dvir Doron, Alina Shitrit, Oren Kobiler
The COVID-19 pandemic caused by the SARS-CoV-2 requires a fast development of antiviral drugs. SARS-CoV-2 viral main protease (Mpro, also called 3C-like protease, 3CLpro) is a potential target for drug design. Crystal and co-crystal structures of the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3f7752af63237058c4f5415fc54d61d2
https://doi.org/10.1101/2020.09.10.288720
https://doi.org/10.1101/2020.09.10.288720
Publikováno v:
Journal of Chemical Information and Modeling. 54:1941-1950
We present a fast and effective covalent docking approach suitable for large-scale virtual screening (VS). We applied this method to four targets (HCV NS3 protease, Cathepsin K, EGFR, and XPO1) with known crystal structures and known covalent inhibit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e42f952553b3ac353376046975305628
https://doi.org/10.1021/ci500175r
https://doi.org/10.1021/ci500175r
Publikováno v:
Journal of Computer-Aided Molecular Design. 26:1217-1228
We present the Consensus Induced Fit Docking (cIFD) approach for adapting a protein binding site to accommodate multiple diverse ligands for virtual screening. This novel approach results in a single binding site structure that can bind diverse chemo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::19e1191245e989da2f834da7695690b5
https://doi.org/10.1007/s10822-012-9611-9
https://doi.org/10.1007/s10822-012-9611-9
Autor:
Nir Ben-Tal, Ori Kalid
Publikováno v:
Journal of Chemical Information and Modeling. 49:865-876
MDM2 is a key regulator of the p53 tumor-suppressor protein. Here we study the effect of modifications of a p53 N-terminal fragment on its binding to MDM2, using implicit-solvent MD and MM-GB/SA calculations. We provide interpretation of existing exp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f6ca07a5f2e39d69c2253019cd00a468
https://doi.org/10.1021/ci800352c
https://doi.org/10.1021/ci800352c
Autor:
Yael Marantz, Alexander Heifetz, Dora Warshaviak, Silvia Noiman, Boaz Inbal, Maya Topf, Merav Fichman, Oren M. Becker, Zvi Naor, Noa Avisar, Sharon Shacham, Ori Kalid, Shay Bar-Haim
Publikováno v:
Proteins: Structure, Function, and Bioinformatics. 57:51-86
G-protein coupled receptors (GPCRs) are a major group of drug targets for which only one x-ray structure is known (the nondrugable rhodopsin), limiting the application of structure-based drug discovery to GPCRs. In this paper we present the details o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e9f73d8d55d83853d9da9bf9ea2b2dc1
https://doi.org/10.1002/prot.20195
https://doi.org/10.1002/prot.20195
Autor:
Manoj Garg, Sharon Shacham, Wen-Yue Gu, Yu Zhang, Yusuke Okuno, Dong Yin, Yan-Yi Jiang, Zhi-Zhou Shi, Seishi Ogawa, Ori Kalid, Yasunobu Nagata, Li-Zhen Liu, Ling-Wen Ding, Ana Maria Varela, Xin Xu, Ming-Rong Wang, De-Chen Lin, Yusuke Sato, Liang Xu, Xuan Meng, Henry Yang, Li Shang, H. Phillip Koeffler, Jia-Jie Hao, Ting Gong
Publikováno v:
Nature genetics, vol 46, iss 5
Nature genetics
Nature genetics
Esophageal squamous cell carcinoma (ESCC) is a world-wide prevalent cancer, which is particularly common in certain regions of Asia. Here we report the whole-exome or targeted deep sequencing of 139 paired ESCC cases, and analysis of somatic copy num
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d8271f09ed94406f7eb840174e7cf11b
https://escholarship.org/uc/item/9ms7n83b
https://escholarship.org/uc/item/9ms7n83b
Publikováno v:
RIUVic. Repositorio Institucional de la Universidad de Vic
instname
instname
The cystic fibrosis transmembrane conductance regulator (CFTR) is an unusual ABC transporter, functioning as a chloride channel critical for fluid homeostasis in multiple organs. Disruption of CFTR function is associated with cystic fibrosis making i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::25e11296f909efca2a50f89b8c0e54a5
http://hdl.handle.net/10854/1994
http://hdl.handle.net/10854/1994
Autor:
Diana R. Wetmore, Alina Shitrit, Yael Marantz, Efrat Ben-Zeev, Sharon Fischman, Robert J. Bridges, Nicoletta Pedemonte, Martin Mense, Hanoch Senderowitz, Ori Kalid, Philip Thomas, Hermann Bihler, Nili Schutz
Publikováno v:
Journal of computer-aided molecular design. 24(12)
Folding correctors of F508del-CFTR were discovered by in silico structure-based screening utilizing homology models of CFTR. The intracellular segment of CFTR was modeled and three cavities were identified at inter-domain interfaces: (1) Interface be
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::66423f6cf5f4007e87e557de70df65c1
https://pubmed.ncbi.nlm.nih.gov/20976528
https://pubmed.ncbi.nlm.nih.gov/20976528