The Antidepressant- and Anxiolytic-Like Effects of the Phosphodiesterase Type-5 Inhibitor Tadalafil are Associated with the Modulation of the Gut-Brain Axis During CNS Autoimmunity.

Autor: Duarte-Silva E; Laboratory of Ultrastructure, Aggeu Magalhães Institute (IAM), Recife, PE, Brazil. eduardo.pduartesilva@gmail.com.; Postgraduate Program in Biosciences and Biotechnology for Health (PPGBBS), Oswaldo Cruz Foundation (FIOCRUZ-PE)/ Aggeu Magalhães Institute (IAM), Recife, PE, Brazil. eduardo.pduartesilva@gmail.com.; Network of Immunity in Infection, Malignancy and Autoimmunity (NIIMA), Universal Scientific Education and Research Network (USERN), Recife, PE, Brazil. eduardo.pduartesilva@gmail.com.; Department of Neurology, University Hospital Düsseldorf, 40255, Düsseldorf, Germany. eduardo.pduartesilva@gmail.com.; Center for Research in Inflammatory Diseases (CRID), Department of Pharmacology, Ribeirão Preto Medical School, University of São Paulo, São Paulo, Brazil. eduardo.pduartesilva@gmail.com.; Feinberg School of Medicine, Northwestern University, Chicago, IL, USA. eduardo.pduartesilva@gmail.com., Oriá AC; Laboratory of Ultrastructure, Aggeu Magalhães Institute (IAM), Recife, PE, Brazil., Mendonça IP; Laboratory of Ultrastructure, Aggeu Magalhães Institute (IAM), Recife, PE, Brazil.; Postgraduate Program in Biological Sciences (PPGCB), Federal University of Pernambuco (UFPE), Recife, PE, Brazil., Paiva IHR; Laboratory of Ultrastructure, Aggeu Magalhães Institute (IAM), Recife, PE, Brazil.; Postgraduate Program in Biological Sciences (PPGCB), Federal University of Pernambuco (UFPE), Recife, PE, Brazil., Leuthier Dos Santos K; Laboratory of Ultrastructure, Aggeu Magalhães Institute (IAM), Recife, PE, Brazil., Sales AJ; Department of Pharmacology, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, SP, Brazil., de Souza JRB; Department of Zoology, Federal University of Pernambuco, Recife, PE, Brazil., Maes M; Department of Psychiatry, Faculty of Medicine, Chulalongkorn University, Bangkok, 10330, Thailand.; Cognitive Impairment and Dementia Research Unit, Faculty of Medicine, Chulalongkorn University, Bangkok, 10330, Thailand.; Department of Psychiatry, Medical University of Plovdiv, Plovdiv, 4002, Bulgaria.; Research Institute, Medical University of Plovdiv, Plovdiv, 4002, Bulgaria.; IMPACT, the Institute for Mental and Physical Health and Clinical Translation, School of Medicine, Deakin University, Barwon Health, Geelong, VIC, Australia.; Mental Health Center, University of Electronic Science and Technology of China, Chengdu, 611731, China., Meuth SG; Department of Neurology, University Hospital Düsseldorf, 40255, Düsseldorf, Germany., Peixoto CA; Laboratory of Ultrastructure, Aggeu Magalhães Institute (IAM), Recife, PE, Brazil. peixoto.christina@gmail.com.; Institute of Science and Technology on Neuroimmunomodulation (INCT-NIM), Oswaldo Cruz Institute, Oswaldo Cruz Foundation, Rio de Janeiro, Brazil. peixoto.christina@gmail.com.

Publikováno v: Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology [J Neuroimmune Pharmacol] 2024 Aug 19; Vol. 19 (1), pp. 45. Date of Electronic Publication: 2024 Aug 19.