Phase I/II study of c-MET inhibitor (DE605) combined with sorafenib in patients with advanced hepatocellular carcinoma

Autor: Bahar Karayel, Sena Durgun, Orhan Öcalgiray

Publikováno v: STEMedicine, Vol 4, Iss 3 (2023)

Background: DE605 is a c-MET inhibitor that can be taken orally. Sorafenib is the only treatment that has been proven to increase overall survival rates in patients with advanced hepatocellular carcinoma (HCC). However, the effectiveness of sorafenib

Externí odkaz: https://doaj.org/article/1d4bd4204d014ea89efb536400e798a2

Genomic Surveillance and Molecular Characterization of SARS-CoV-2 Variants During the Peak of the Pandemic in Türkiye.

Autor: Akçeşme FB; Division of Biostatistics and Medical Informatics, Department of Basic Medical Sciences, Hamidiye Faculty of Medicine, University of Health Sciences, Istanbul, Turkey., Köprülü TK; Division of Medical Laboratory Techniques, Department of Medical Services and Techniques, Hamidiye Health Services Vocational School, University of Health Sciences, Istanbul, Turkey.; Experimental Medicine Application and Research Center, University of Health Sciences, Istanbul, Turkey., Çam BE; Department of Molecular Biology and Genetics, Faculty of Science and Letters, Yıldız Technical University, Istanbul, Turkey., İş Ş; Division of Bioinformatics, Department of Molecular Biotechnology, Faculty of Science, Turkish-German University, Istanbul, Turkey.; Division of Medical Biology, Department of Basic Medical Sciences, Hamidiye Faculty of Medicine, University of Health Sciences, Istanbul, Turkey., Keskin BC; Genome Research Center, Life Sciences, Marmara Research Center, TUBITAK, Kocaeli, Turkey., Akçeşme B; Division of Medical Biology, Department of Basic Medical Sciences, Hamidiye Faculty of Medicine, University of Health Sciences, Istanbul, Turkey. betul.akcesme@sbu.edu.tr., Baydili KN; Department of Biostatistics and Medical Informatics, Hamidiye Faculty of Medicine, University of Health Sciences, Istanbul, Turkey., Gezer B; Experimental Medicine Application and Research Center, University of Health Sciences, Istanbul, Turkey.; Department of Molecular Medicine, Hamidiye Faculty of Health Sciences, University of Health Sciences, Istanbul, Turkey., Balkan J; Experimental Medicine Application and Research Center, University of Health Sciences, Istanbul, Turkey.; Department of Molecular Medicine, Hamidiye Faculty of Health Sciences, University of Health Sciences, Istanbul, Turkey., Uçar B; Genome Research Center, Life Sciences, Marmara Research Center, TUBITAK, Kocaeli, Turkey.; Department of Biology, Faculty of Science, Marmara University, Istanbul, Turkey., Gürsoy O; Department of Computer Sciences and Engineering, Faculty of Engineering and Natural Sciences, International University of Sarajevo, Sarajevo, Bosnia and Herzegovina., Yıldız MT; Hamidiye Institute of Science, Molecular Medicine, Hamidiye Health Services Vocational School, University of Health Sciences, Istanbul, Turkey., Kurt H; Department of Medical Biology, Hamidiye International Faculty of Medicine, University of Health Sciences, Istanbul, Turkey., Ünal N; Department of Microbiology, Adana City Training and Research Hospital, Adana, Turkey., Korkmaz C; Division of Thoracic Diseases, Department of Internal Medicine, Faculty of Medicine, Necmettin Erbakan University, Konya, Turkey., Saral ÖB; Clinic for Infectious Diseases and Clinical Microbiology, Trabzon Kanuni Training and Research Hospital, Trabzon, Turkey., Demirkol B; Department of Chest Diseases, Basaksehir Cam and Sakura City Hospital, University of Health Sciences, Istanbul, Turkey., Çağ Y; Division of Infectious Diseases and Clinical Microbiology, Department of Internal Medicine, Faculty of Medicine, İstanbul Medeniyet University, Istanbul, Turkey., Abakay H; Clinic for Infectious Diseases, İzmir Tepecik Training and Research Hospital, İzmir, Turkey., Köse Ş; Division of Infectious Diseases, Department of Internal Medicine, Dokuz Eylül Univesity, İzmir, Turkey., Türkez H; Department of Medical Biology, Faculty of Medicine, Atatürk University, Erzurum, Turkey., Çadırcı K; Department of Internal Medicine, Erzurum Regional Education and Research Hospital, Erzurum, Turkey., Altındiş M; Division of Medical Microbiology, Department of Basic Medical Sciences, Faculty of Medicine, Sakarya University, Sakarya, Turkey., Gülseren YD; Department of Medical Microbiology, Balıkesir Atatürk City Hospital, Balıkesir, Turkey., Aslan N; Emergency Service, Sakarya University Training and Research Hospital, Sakarya, Turkey., Özel A; Experimental Medicine Application and Research Center, University of Health Sciences, Istanbul, Turkey.; Dr. Orhan Öcalgiray Molecular Biology-Biotechnology and Genetics Research Center (ITU-MOBGAM), Faculty of Science and Letters, İstanbul Technical University, Istanbul, Turkey., Karagöl MA; Department of Chest Diseases, Basaksehir Cam and Sakura City Hospital, University of Health Sciences, Istanbul, Turkey., Mutluay N; Department of Medical Microbiology, Adana City Training and Research Hospital, Adana, Turkey.; Division of Medical Microbiology, Department of Basic Medical Sciences, Faculty of Medicine, Çukurova University, Adana, Turkey., Tekin Ş; Division of Medical Biology, Department of Basic Medical Sciences, Hamidiye Faculty of Medicine, University of Health Sciences, Istanbul, Turkey.

Publikováno v: Biochemical genetics [Biochem Genet] 2024 Nov 08. Date of Electronic Publication: 2024 Nov 08.

Revealing the role of the X25 domains through the characterization of truncated variants of amylopullulanase enzyme from Thermoanaerobacter brockii brockii.

Autor: Kayrav A; Istanbul Technical University, Faculty of Science and Letters, Department of Molecular Biology and Genetics, 34469 Istanbul, Türkiye; Istanbul Technical University, Dr. Orhan Öcalgiray Molecular Biology-Biotechnology and Genetics Research Center, Istanbul, Türkiye., Mumcu H; Istanbul Technical University, Faculty of Science and Letters, Department of Molecular Biology and Genetics, 34469 Istanbul, Türkiye; Istanbul Technical University, Dr. Orhan Öcalgiray Molecular Biology-Biotechnology and Genetics Research Center, Istanbul, Türkiye., Durmus N; Istanbul Technical University, Faculty of Science and Letters, Department of Molecular Biology and Genetics, 34469 Istanbul, Türkiye; Istanbul Technical University, Dr. Orhan Öcalgiray Molecular Biology-Biotechnology and Genetics Research Center, Istanbul, Türkiye., Karaguler NG; Istanbul Technical University, Faculty of Science and Letters, Department of Molecular Biology and Genetics, 34469 Istanbul, Türkiye; Istanbul Technical University, Dr. Orhan Öcalgiray Molecular Biology-Biotechnology and Genetics Research Center, Istanbul, Türkiye. Electronic address: karaguler@itu.edu.tr.

Publikováno v: International journal of biological macromolecules [Int J Biol Macromol] 2024 Jun; Vol. 270 (Pt 2), pp. 132404. Date of Electronic Publication: 2024 May 14.

Development of a nucleic acid-based lateral flow device as a reliable diagnostic tool for respiratory viral infections.

Autor: Akalın P; Dr. Orhan Öcalgiray Molecular Biology, Biotechnology and Genetics Research Center (ITU-MOBGAM), Istanbul Technical University, Maslak 34469, Istanbul, Turkey., Yazgan-Karataş A; Dr. Orhan Öcalgiray Molecular Biology, Biotechnology and Genetics Research Center (ITU-MOBGAM), Istanbul Technical University, Maslak 34469, Istanbul, Turkey.; Faculty of Science and Letters, Department of Molecular Biology and Genetics, Istanbul Technical University, Maslak 34469 Istanbul, Turkey.

Publikováno v: MethodsX [MethodsX] 2023 Sep 09; Vol. 11, pp. 102372. Date of Electronic Publication: 2023 Sep 09 (Print Publication: 2023).

Draft Genome Sequence of Virgibacillus sp. Strain AGTR, Isolated from Hypersaline Lake Acıgöl in Turkey.

Autor: Menekse Kılıc M; Istanbul Technical University, Faculty of Science and Letters, Department of Molecular Biology and Genetics, Istanbul, Turkey.; Istanbul Topkapi University, Plato Vocational School, Medical Laboratory Techniques Program, Istanbul, Turkey.; Istanbul Technical University, Dr. Orhan Öcalgiray Molecular Biology, Biotechnology, and Genetics Research Center, Istanbul, Turkey., Balci N; Istanbul Technical University, Department of Geological Engineering, Geomicrobiology and Biogeochemistry Laboratory, Istanbul, Turkey., Gul Karaguler N; Istanbul Technical University, Faculty of Science and Letters, Department of Molecular Biology and Genetics, Istanbul, Turkey.; Istanbul Topkapi University, Plato Vocational School, Medical Laboratory Techniques Program, Istanbul, Turkey.

Publikováno v: Microbiology resource announcements [Microbiol Resour Announc] 2022 Oct 20; Vol. 11 (10), pp. e0055522. Date of Electronic Publication: 2022 Aug 31.